Article
Biochemistry & Molecular Biology
Enrique Luengo, Paula Trigo-Alonso, Cristina Fernandez-Mendivil, Angel Nunez, Cesar Porrero, Nuria Garcia-Magro, Pilar Negredo, Sergio Senar, Cristina Sanchez-Ramos, Juan A. Bernal, Alberto Rabano, Jeroen Hoozemans, Ana I. Casas, Manuela G. Lopez, Marta del Campo, Harald H. H. W. Schmidt
Summary: This study reveals that NOX4 plays a significant role in tauopathies. By modulating autophagy-lysosomal pathway, the absence of NOX4 reduces the accumulation of pathological tau, improves tauopathy, and prevents neurotoxicity and cognitive decline. This suggests that NOX4 could be a potential therapeutic target for tauopathies.
Review
Biochemistry & Molecular Biology
Victoria Campos-Pena, Pavel Pichardo-Rojas, Talia Sanchez-Barbosa, Emma Ortiz-Islas, Citlali Ekaterina Rodriguez-Perez, Pedro Montes, Gerardo Ramos-Palacios, Daniela Silva-Adaya, Rafael Valencia-Quintana, Jorge Francisco Cerna-Cortes, Danira Toral-Rios
Summary: The presence of insoluble aggregates of amyloid beta (A beta) in the brain is a hallmark of Alzheimer's disease, and it has been shown to contribute to extensive neuronal loss. The distribution and content of cholesterol in the membrane play an important role in the production and accumulation of A beta peptides, leading to dysfunction and neuronal death. The monomeric forms of A beta peptides can trigger changes in Tau phosphorylation and cognitive function through their internalization by specific receptors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Heng Sun, Yan Zhong, Xiandi Zhu, Hongwei Liao, Jiyoung Lee, Ying Chen, Lijuan Ma, Jiafeng Ren, Meng Zhao, Mengjiao Tu, Fangyuan Li, Hong Zhang, Mei Tian, Daishun Ling
Summary: The study introduces a promising nanotechnology-based strategy for tauopathy-homing and autophagy-mediated specific removal of pathogenic tau in Alzheimer's disease (AD), showing selective accumulation in cells undergoing tauopathy and promoting clearance of pathogenic tau accumulation, consequently improving neuron viability and cognitive functions in AD rats.
Article
Biochemistry & Molecular Biology
Christophe Mesangeau, Pascal Carato, Nicolas Renault, Mathilde Coevoet, Paul-Emmanuel Larchanche, Amelie Barczyk, Luc Buee, Nicolas Sergeant, Patricia Melnyk
Summary: This paragraph discusses the rationale and methods for selecting small drug compounds based on structure-activity relationships. It also describes the various screening parameters used to identify compounds with potential anti-Alzheimer activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Neurosciences
Yiyuan Xia, Zhi-Hao Wang, Zhentao Zhang, Xia Liu, Shan Ping Yu, Jian-Zhi Wang, Xiao-Chuan Wang, Keqiang Ye
Summary: The newly identified delta-secretase, AEP, cleaves both APP and Tau, promoting Alzheimer's disease. It also cleaves BACE1, enhancing its enzymatic activity and contributing to senile plaque deposition in AD. The interaction between delta-secretase and BACE1 worsens AD pathogenesis.
PROGRESS IN NEUROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Arpita Dey, Ran Chen, Feng Li, Subhamita Maitra, Jean-Francois Hernandez, Guo-Chun Zhou, Bruno Vincent
Summary: The study shows that andrographolide and its derivatives have the potential to be used as anti-Alzheimer's disease drugs, with andrographolide and its derivative behaving as alpha-secretase activators, while other compounds act as beta-secretase inhibitors.
Article
Agriculture, Multidisciplinary
Jian Bao, Zheng Liang, Xiaokang Gong, Yanna Zhao, Mengjuan Wu, Wei Liu, Chenyu Tu, Xiaochuan Wang, Xiji Shu
Summary: This study found that Tangeretin (TAN) exhibits antidementia activity in APPswe/PSEN1dE9 transgenic mice, reducing cognitive impairment, synaptic impairments, and beta-amyloid accumulations. TAN also showed powerful inhibitory activity against beta-secretase, suggesting it as a potential drug for preventing Alzheimer's disease pathology.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Shiveena Bhatia, Manjinder Singh, Pratibha Sharma, Somdutt Mujwar, Varinder Singh, Krishna Kumar Mishra, Thakur Gurjeet Singh, Tanveer Singh, Sheikh Fayaz Ahmad
Summary: Alzheimer's disease, the leading cause of dementia, is characterized by the deposition of plaques and tangles in the brain, leading to cell degeneration. Researchers are developing BACE-1 enzyme inhibitors to prevent plaque buildup. In this study, Elenbecestat analogues were analyzed using structure-based drug design and scaffold morphing, and SB306 and SB12 were found to interact well with the catalytic dyad motifs of the enzyme, showing drug-like properties and high thermodynamic stability.
Article
Biochemistry & Molecular Biology
Yuqi Li, Linkun Zhang, Junkui Jiao, Qiuying Ding, Yanping Li, Zhibo Zhao, Jinfeng Luo, Yaxi Chen, Xiongzhong Ruan, Lei Zhao
Summary: CD36 plays a key role in protecting mice from diet-induced liver injury and fibrosis in MAFLD. The research reveals that CD36 deficiency increases susceptibility to NASH diet-induced liver injury and fibrosis. CD36 forms a complex with Notch1 and ?-secretase in lipid rafts, blocking the interaction and inhibiting the production of N1ICD.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Neurosciences
Ching-Pang Chang, Ya-Gin Chang, Pei-Yun Chuang, Thi Ngoc Anh Nguyen, Kuo-Chen Wu, Fang-Yi Chou, Sin-Jhong Cheng, Hui-Mei Chen, Lee-Way Jin, Kevin Carvalho, Vincent Huin, Luc Buee, Yung-Feng Liao, Chun-Jung Lin, David Blum, Yijuang Chern
Summary: Targeting adenosine metabolism can reduce Tau pathology and improve neuronal dysfunctions in tauopathies, providing a novel strategy for treatment.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2021)
Review
Neurosciences
Yee Jie Yeap, Nagaendran Kandiah, Dean Nizetic, Kah-Leong Lim
Summary: Alzheimer's disease (AD) is the most common cause of dementia, affecting millions of elderly individuals worldwide. Despite extensive research, the cause of AD remains controversial and there is currently no cure. However, recent studies have identified the protease BACE2 as a potential therapeutic target for AD due to its non-amyloidogenic role in preventing the generation of toxic amyloid-beta peptides. This review discusses emerging evidence supporting the neuroprotective role of BACE2 in AD and provides an update on the identification of gene mutations linked to increased risk and earlier disease onset.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Cell Biology
Xin Chen, Ana Joyce Munoz-Arellano, Dina Petranovic
Summary: UBB+1 accumulation is linked to UPS dysfunction and neurodegeneration, while low UBB+1 expression activates the autophagy pathway and reduces intracellular A beta toxicity.
Review
Neurosciences
Vladimir Rudajev, Jiri Novotny
Summary: Alzheimer's disease is a neurodegenerative disorder characterized by the production and aggregation of amyloid beta, which leads to cell membrane disruption and cell death. Cholesterol, as a major component of cell membranes, plays a significant role in the progression of AD, although its effects are inconsistent.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Yin Xu, Nicholas E. Propson, Shuqi Du, Wen Xiong, Hui Zheng
Summary: Studies indicate that microglial-specific autophagy, represented by Atg7, plays a crucial role in regulating lipid metabolism and neuroinflammation. Deletion of Atg7 in microglia leads to a proinflammatory status and exacerbates intraneuronal tau pathology.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Roberto A. Galeana-Ascencio, Liliana Mendieta, Daniel I. Limon, Dino Gnecco, Joel L. Teran, Maria L. Orea, Alan Carrasco-Carballo
Summary: This study identifies five potential BACE-1 inhibitor drugs through in silico studies using molecular docking and ADME prediction. These candidates exhibit specific pharmacophore features and interactions with key amino acids in BACE-1. The study provides insights into the potential use of in silico methods for drug repurposing and identification of new candidates for the treatment of Alzheimer's disease, especially those targeting BACE-1.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Clinical Neurology
Johanna Andrea Gutierrez-Vargas, Gloria Patricia Cardona-Gomez
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2020)
Article
Neurosciences
P. A. Perez-Corredor, J. A. Gutierrez-Vargas, L. Ciro-Ramirez, Norman Balcazar, G. P. Cardona-Gomez
Summary: Obesity induced by a high fructose diet exacerbates neuronal loss, inflammation, and plasticity impairment in the hippocampus after cerebral ischemia.
NUTRITIONAL NEUROSCIENCE
(2022)
Review
Cell Biology
Jenny Paola Alfaro-Garcia, Maria Camila Granados-Alzate, Miguel Vicente-Manzanares, Juan Carlos Gallego-Gomez
Summary: Virus-related mortality and morbidity are often caused by cell/tissue damage and cancer, driven by genetic and epigenetic changes induced by oncogenic viruses. Boolean networks, a modeling approach connecting data with logical operators, can provide novel insights and accelerate discoveries in virus-induced cellular plasticity and cell reprogramming.
Article
Neurosciences
P. A. Perez-Corredor, P. Oluwatomilayo-Ojo, J. A. Gutierrez-Vargas, G. P. Cardona-Gomez
Summary: Obesity is associated with worse outcomes after cerebral ischemia, but the cellular mechanisms remain unclear. In this study, rats fed a high fructose diet (HFD) were used as a model of obesity. It was found that obese rats had dyslipidemia and high levels of proinflammatory cytokines. The glia from obese rats showed altered morphology, suggesting hyperreactivity related to neurological and motor deficits. Plasma from obese rats induced activation of endothelial cells and the release of more extracellular vesicles (EVs). These EVs caused an increase in NF-kappa B and astrocyte cytotoxicity. These findings suggest that obesity activates proinflammatory signals in endothelial cells, leading to the release of EVs that contribute to astrocyte activation.
NUTRITIONAL NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Alexis Felipe Rojas-Cruz, Juan Carlos Gallego-Gomez, Clara Isabel Bermudez-Santana
Summary: This study provides insights into the protein-coding and viral genome architecture of Betacoronaviruses and reveals the potential drivers of viral diversification and the factors underlying cross-species transmission. The close relationship between bat viruses and Betacoronaviruses' most recent common ancestor is highlighted, and missense mutations in viral proteins are found to play a crucial role in viral diversification. The study also uncovers the overlap between positively selected codon sites and mutations disrupting RNA genome structures, suggesting their importance in crossing the species barrier. Furthermore, highly conserved RNA structures in Betacoronavirus genomes are identified, which may have essential functions in the biology of the virus.
Article
Virology
Yaneth M. Brand, Vicky Roa-Linares, Carolina Santiago-Dugarte, Esther del Olmo, Jose Luis Lopez-Perez, Liliana Betancur-Galvis, Juan Carlos Gallego-Gomez, Arturo San Feliciano
Summary: Dengue virus (DENV) infection is a widespread arbovirosis for which there are no approved medications. This study focuses on host-targeted antiviral (HTA) drugs and tests the effects of fifty-seven podophyllotoxin-related cyclolignans on DENV-2 infected cells. The most promising compound, S.71, was found to decrease viral yield through an HTA-related mechanism and showed potential as a drug with standard pharmacokinetic properties.
Article
Microbiology
Yaneth Miranda Brand, Astrid M. Bedoya, Liliana Betancur-Galvis, Juan Carlos Gallego-Gomez
Summary: This study characterized the infection of ZIKV in PC3 cells, demonstrating their susceptibility and permissiveness without causing cytopathic effects. The study also revealed that PC3 cells modulate the antiviral response through the expression of suppressor molecule SOCS-1.
Review
Virology
Vicky C. Roa-Linares, Manuela Escudero-Florez, Miguel Vicente-Manzanares, Juan C. Gallego-Gomez
Summary: The recent COVID-19 crisis has highlighted the importance of RNA-based viruses and the challenges they pose in terms of vaccination and treatment due to their high mutation capacity and ability to manipulate the host immune system.
Article
Virology
Manuela Escudero-Florez, David Torres-Hoyos, Yaneth Miranda-Brand, Juan Carlos Gallego-Gomez, Miguel Vicente-Manzanares
Summary: This study demonstrates that DENV infection induces endothelial dysfunction by activating c-ABL kinase, leading to disruption of intercellular junctions and increased cell motility. Inhibition or silencing of c-ABL reverses these effects, indicating that c-ABL plays a crucial role in DENV-induced endothelial phenotypic changes.
Article
Neurosciences
Oluwatomilayo Patience Ojo, Paula Andrea Perez-Corredor, Johanna Andrea Gutierrez-Vargas, Oluwole Busayo Akinola, Gloria Patricia Cardona-Gomez
Summary: The study evaluated the long-term effects of a high fructose diet and cerebral ischemia on neurological, cognitive, and emotional performance in male rats. Results showed that fructose intake led to weight gain, high blood glucose, and reduced insulin sensitivity. The coexistence of fructose intake and cerebral ischemia worsened neurological performance and resulted in alterations in learning and emotional skills.
NUTRITIONAL NEUROSCIENCE
(2022)
Article
Social Sciences, Interdisciplinary
Juan Carlos Gallego-Gomez, German Guerrero-Pino
Summary: This study aims to precisely define the concept of Experimental Systems (ES) within the context of phenomenotechnics, showing its utility in analyzing and understanding a specific case in Contemporary Cell Biology. Starting from the origins of Cellular Theory, Cytology, and Biochemistry, the study explores the development of Live Cell Imaging as a key element in scientific research. The notion of ES by Rheinberger provides a finer characterization of real science, emphasizing the co-generation of epistemic-scientific objects within a space of representation and experimental traces. The integration of philosophical reflections with scientific practice in the laboratory is highlighted as a crucial aspect often overlooked in the philosophy of science.
REVUE D ANTHROPOLOGIE DES CONNAISSANCES
(2021)
Review
Plant Sciences
Victoria Hincapie, Juan Carlos Gallego-Gomez
Summary: Epithelial-to-Mesenchymal Transition (EMT) is a conserved process in vertebrates, involved in cell differentiation and potential metastasis. Viral infections can trigger EMT, leading to tumor development and highlighting the importance of understanding the host-virus relationship for disease pathogenesis.
ACTA BIOLOGICA COLOMBIANA
(2021)
Article
Geriatrics & Gerontology
Juan Villar-Vesga, Julian Henao-Restrepo, Danielle C. Voshart, David Aguillon, Andres Villegas, Diana Castano, Julian D. Arias-Londono, Inge S. Zuhorn, Lais Ribovski, Lara Barazzuol, Gloria P. Cardona-Gomez, Rafael Posada-Duque
FRONTIERS IN AGING NEUROSCIENCE
(2020)
Article
Pharmacology & Pharmacy
Natalia Lopez-Barbosa, Juan G. Garcia, Javier Cifuentes, Lina M. Castro, Felipe Vargas, Carlos Ostos, Gloria P. Cardona-Gomez, Alher Mauricio Hernandez, Juan C. Cruz
Article
Parasitology
Alexandra Milena Cuartas-Lopez, Juan Carlos Gallego-Gomez
MEMORIAS DO INSTITUTO OSWALDO CRUZ
(2020)