Differential Role of Adipose Tissues in Obesity and Related Metabolic and Vascular Complications

Crosstalk between adipokines and myokines in fat browning

(2016) A. Rodríguez et al.   Acta Physiologica

Obesity-Related Perivascular Adipose Tissue Damage Is Reversed by Sustained Weight Loss in the RatHighlights

(2016) Charlotte E. Bussey et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Role of Brown Fat in Lipoprotein Metabolism and Atherosclerosis

(2016) Geerte Hoeke et al.   CIRCULATION RESEARCH

Pharmacologic Approaches to Weight Management: Recent Gains and Shortfalls in Combating Obesity

(2016) Katherine H. Saunders et al.   Current Atherosclerosis Reports

Exercise-Mediated Effects on White and Brown Adipose Tissue Plasticity and Metabolism

(2016) Diane M. Sepa-Kishi et al.   EXERCISE AND SPORT SCIENCES REVIEWS

Browning of White Fat: Novel Insight Into Factors, Mechanisms, and Therapeutics

(2016) Nevena Jeremic et al.   JOURNAL OF CELLULAR PHYSIOLOGY

A 52-week pilot study of the effects of exenatide on body weight in patients with hypothalamic obesity

(2016) Jefferson P. Lomenick et al.   Obesity

New PPARγ partial agonist improves obesity-induced metabolic alterations and atherosclerosis in LDLr−/− mice

(2016) Jacqueline C. Silva et al.   PHARMACOLOGICAL RESEARCH

Mitochondria in White, Brown, and Beige Adipocytes

(2016) Miroslava Cedikova et al.   Stem Cells International

Transcriptome profiling of brown adipose tissue during cold exposure reveals extensive regulation of glucose metabolism

(2015) Qin Hao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Irisin improves endothelial function in obese mice through the AMPK-eNOS pathway

(2015) Fang Han et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Irisin protects against endothelial injury and ameliorates atherosclerosis in apolipoprotein E-Null diabetic mice

(2015) Junyan Lu et al.   ATHEROSCLEROSIS

α-Lipoic acid treatment increases mitochondrial biogenesis and promotes beige adipose features in subcutaneous adipocytes from overweight/obese subjects

(2015) Marta Fernández-Galilea et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Activation of Human Brown Adipose Tissue by a β3-Adrenergic Receptor Agonist

(2015) Aaron M. Cypess et al.   Cell Metabolism

Irisin inhibits hepatic gluconeogenesis and increases glycogen synthesis via the PI3K/Akt pathway in type 2 diabetic mice and hepatocytes

(2015) T.-Y. Liu et al.   CLINICAL SCIENCE

Human perivascular adipose tissue dysfunction as a cause of vascular disease: Focus on vascular tone and wall remodeling

(2015) Gulsev Ozen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Circulating dipeptidyl peptidase-4 activity is associated with insulin resistance in type 1 diabetic patients

(2015) K. Blaslov et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Ghrelin Signalling on Food Reward: A Salient Link Between the Gut and the Mesolimbic System

(2015) M. Perello et al.   JOURNAL OF NEUROENDOCRINOLOGY

Effects of Obesity on Perivascular Adipose Tissue Vasorelaxant Function: Nitric Oxide, Inflammation and Elevated Systemic Blood Pressure

(2015) Reza Aghamohammadzadeh et al.   JOURNAL OF VASCULAR RESEARCH

Structure, production and signaling of leptin

(2015) Heike Münzberg et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Cognitive and autonomic determinants of energy homeostasis in obesity

(2015) Denis Richard   Nature Reviews Endocrinology

Irisin Controls Growth, Intracellular Ca2+ Signals, and Mitochondrial Thermogenesis in Cardiomyoblasts

(2015) Chao Xie et al.   PLoS One

Brown Adipose Tissue Harbors a Distinct Sub-Population of Regulatory T Cells

(2015) Dasa Medrikova et al.   PLoS One

Musclin is an activity-stimulated myokine that enhances physical endurance

(2015) Ekaterina Subbotina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dipeptidyl Peptidase 4: A New Link between Diabetes Mellitus and Atherosclerosis?

(2015) Wellington Santana da Silva Júnior et al.   Biomed Research International

Effects of Glucagon-Like Peptide-1 Receptor Agonists on Weight Loss in Patients with Type 2 Diabetes: A Systematic Review and Network Meta-Analysis

(2015) Feng Sun et al.   Journal of Diabetes Research

Brown adipose tissue activity as a target for the treatment of obesity/insulin resistance

(2015) Anne-Laure Poher et al.   Frontiers in Physiology

Beneficial Effects of Evogliptin, a Novel Dipeptidyl Peptidase 4 Inhibitor, on Adiposity with Increased Ppargc1a in White Adipose Tissue in Obese Mice

(2015) Yu-Na Chae et al.   PLoS One

Perivascular Adipose Tissue in Vascular Function and Disease

(2014) Nicholas K. Brown et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Proinflammatory Phenotype of Perivascular Adipocytes

(2014) Abdullah Omar et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

A Switch from White to Brown Fat Increases Energy Expenditure in Cancer-Associated Cachexia

(2014) Michele Petruzzelli et al.   Cell Metabolism

β-Aminoisobutyric Acid Induces Browning of White Fat and Hepatic β-Oxidation and Is Inversely Correlated with Cardiometabolic Risk Factors

(2014) Lee D. Roberts et al.   Cell Metabolism

Brain responses to food and weight loss

(2014) Preeshila Behary et al.   EXPERIMENTAL PHYSIOLOGY

Neural innervation of white adipose tissue and the control of lipolysis

(2014) Timothy J. Bartness et al.   FRONTIERS IN NEUROENDOCRINOLOGY

An endocrine role for brown adipose tissue?

(2013) Joan Villarroya et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Adipose Dipeptidyl Peptidase-4 and Obesity: Correlation with insulin resistance and depot-specific release from adipose tissue in vivo and in vitro

(2013) H. Sell et al.   DIABETES CARE

White, Brown, Beige/Brite: Different Adipose Cells for Different Functions?

(2013) Marta Giralt et al.   ENDOCRINOLOGY

Emerging gliptins for type 2 diabetes

(2013) Avivit Cahn et al.   EXPERT OPINION ON EMERGING DRUGS

The effects of acute and chronic exercise on PGC-1α, irisin and browning of subcutaneous adipose tissue in humans

(2013) Frode Norheim et al.   FEBS Journal

Long-term Drug Treatment for Obesity

(2013) Susan Z. Yanovski et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Visfatin/Nampt: An Adipokine with Cardiovascular Impact

(2013) Tania Romacho et al.   MEDIATORS OF INFLAMMATION

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

(2012) Jun Wu et al.   CELL

Loss of Perivascular Adipose Tissue on Peroxisome Proliferator–Activated Receptor-γ Deletion in Smooth Muscle Cells Impairs Intravascular Thermoregulation and Enhances Atherosclerosis

(2012) Lin Chang et al.   CIRCULATION

Paradoxical Roles of Perivascular Adipose Tissue in Atherosclerosis and Hypertension

(2012) Lin Chang et al.   CIRCULATION JOURNAL

The secretion pattern of perivascular fat cells is different from that of subcutaneous and visceral fat cells

(2012) K. Rittig et al.   DIABETOLOGIA

Brown Fat Lipoatrophy and Increased Visceral Adiposity through a Concerted Adipocytokines Overexpression Induces Vascular Insulin Resistance and Dysfunction

(2012) Almudena Gómez-Hernández et al.   ENDOCRINOLOGY

Anti-obesity drugs: a review about their effects and their safety

(2012) Giuseppe Derosa et al.   Expert Opinion On Drug Safety

Visfatin May Be a Novel Marker for Identifying Stages of Essential Hypertension in Advanced Age Patients

(2012) Fahri Gunes et al.   INTERNAL MEDICINE

Adaptive thermogenesis can make a difference in the ability of obese individuals to lose body weight

(2012) A Tremblay et al.   INTERNATIONAL JOURNAL OF OBESITY

Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans

(2012) Véronique Ouellet et al.   JOURNAL OF CLINICAL INVESTIGATION

Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes

(2012) Marica Bordicchia et al.   JOURNAL OF CLINICAL INVESTIGATION

A new, powerful player in lipoprotein metabolism: brown adipose tissue

(2012) Alexander Bartelt et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

Randomized Placebo-Controlled Clinical Trial of Lorcaserin for Weight Loss in Type 2 Diabetes Mellitus: The BLOOM-DM Study

(2012) Patrick M. O'Neil et al.   Obesity

Paracrine regulation of vascular tone, inflammation and insulin sensitivity by perivascular adipose tissue

(2012) Etto C. Eringa et al.   VASCULAR PHARMACOLOGY

Brown adipose tissue

(2012) Kristy Townsend et al.   Adipocyte

Similarity of mouse perivascular and brown adipose tissues and their resistance to diet-induced inflammation

(2011) Timothy P. Fitzgibbons et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

NF-κB, Inflammation, and Metabolic Disease

(2011) Rebecca G. Baker et al.   Cell Metabolism

Evaluation of macrophage plasticity in brown and white adipose tissue

(2011) M. Teresa Ortega et al.   CELLULAR IMMUNOLOGY

Human epicardial fat: what is new and what is missing?

(2011) Harold S Sacks et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Increased levels and adipose tissue expression of visfatin in morbidly obese women: the relationship with pro-inflammatory cytokines

(2011) Ximena Terra et al.   CLINICAL ENDOCRINOLOGY

Perivascular Adipose Tissue and Its Role in Type 2 Diabetes and Cardiovascular Disease

(2011) Rick I. Meijer et al.   Current Diabetes Reports

Thermogenic Activation Induces FGF21 Expression and Release in Brown Adipose Tissue

(2011) Elayne Hondares et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comparison of effects of diet versus exercise weight loss regimens on LDL and HDL particle size in obese adults

(2011) Krista A Varady et al.   Lipids in Health and Disease

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(2011) Dionysios Chartoumpekis et al.   MOLECULAR MEDICINE

Brown adipose tissue activity controls triglyceride clearance

(2011) Alexander Bartelt et al.   NATURE MEDICINE

Long-Term Persistence of Hormonal Adaptations to Weight Loss

(2011) Priya Sumithran et al.   NEW ENGLAND JOURNAL OF MEDICINE

The effect of systemic anti-tumor necrosis factor-alpha treatment on Porphyromonas gingivalis infection in type 2 diabetic mice

(2010) Mayuko Takano et al.   ARCHIVES OF ORAL BIOLOGY

Endovascular Injury Induces Rapid Phenotypic Changes in Perivascular Adipose Tissue

(2010) Minoru Takaoka et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Epicardial Perivascular Adipose-Derived Leptin Exacerbates Coronary Endothelial Dysfunction in Metabolic Syndrome via a Protein Kinase C-β Pathway

(2010) Gregory A. Payne et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Central leptin signalling: Beyond the arcuate nucleus

(2010) Zorica Jovanovic et al.   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

Human Brown Adipose Tissue

(2010) Sven Enerbäck   Cell Metabolism

Hepatic FGF21 Expression Is Induced at Birth via PPARα in Response to Milk Intake and Contributes to Thermogenic Activation of Neonatal Brown Fat

(2010) Elayne Hondares et al.   Cell Metabolism

Obesity, Inflammation, and Cardiovascular Risk

(2010) P Mathieu et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Adaptive thermogenesis in humans

(2010) M Rosenbaum et al.   INTERNATIONAL JOURNAL OF OBESITY

Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat

(2010) T. J. Schulz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Beige Can Be Slimming

(2010) J. Ishibashi et al.   SCIENCE

Perspective: Does brown fat protect against diseases of aging?

(2009) Mark P. Mattson   AGEING RESEARCH REVIEWS

Obesity Promotes Inflammation in Periaortic Adipose Tissue and Angiotensin II-Induced Abdominal Aortic Aneurysm Formation

(2009) Sara B. Police et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Recruitment of brown fat and conversion of white into brown adipocytes: Strategies to fight the metabolic complications of obesity?

(2009) Dominique Langin   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The Control of Food Intake: Behavioral versus Molecular Perspectives

(2009) Stephen C. Woods   Cell Metabolism

Local Inflammation and Hypoxia Abolish the Protective Anticontractile Properties of Perivascular Fat in Obese Patients

(2009) Adam S. Greenstein et al.   CIRCULATION

Proinflammatory Phenotype of Perivascular Adipocytes

(2009) Tapan K. Chatterjee et al.   CIRCULATION RESEARCH

PPARγ and its ligands: therapeutic implications in cardiovascular disease

(2009) Luis Villacorta et al.   CLINICAL SCIENCE

Endothelial Nitric Oxide Synthase Uncoupling and Perivascular Adipose Oxidative Stress and Inflammation Contribute to Vascular Dysfunction in a Rodent Model of Metabolic Syndrome

(2009) Chiara Marchesi et al.   HYPERTENSION

Chronic Peroxisome Proliferator-activated Receptor γ (PPARγ) Activation of Epididymally Derived White Adipocyte Cultures Reveals a Population of Thermogenically Competent, UCP1-containing Adipocytes Molecularly Distinct from Classic Brown Adipocytes

(2009) Natasa Petrovic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

(2009) Satoshi Nishimura et al.   NATURE MEDICINE

Dyslipidemia in type 2 diabetes mellitus

(2009) Arshag D Mooradian   Nature Reviews Endocrinology

Identification and Importance of Brown Adipose Tissue in Adult Humans

(2009) Aaron M. Cypess et al.   NEW ENGLAND JOURNAL OF MEDICINE

Brown Fat and Skeletal Muscle: Unlikely Cousins?

(2008) Stephen R. Farmer   CELL

Perivascular fatty tissue at the brachial artery is linked to insulin resistance but not to local endothelial dysfunction

(2008) K. Rittig et al.   DIABETOLOGIA

Fibroblast Growth Factor 21 Corrects Obesity in Mice

(2008) Tamer Coskun et al.   ENDOCRINOLOGY

Molecular processes that handle — and mishandle — dietary lipids

(2008) Kevin Jon Williams   JOURNAL OF CLINICAL INVESTIGATION

Endocrine alterations in response to calorie restriction in humans

(2008) Leanne M. Redman et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY