C-Linked 8-aryl guanine nucleobase adducts: biological outcomes and utility as fluorescent probes

Photophysical properties of push–pull 8-aryl-deoxyguanosine probes within duplex and G-quadruplex structures

(2016) Darian J. M. Blanchard et al.   Journal of Materials Chemistry C

Positional Impact of Fluorescently Modified G-Tetrads within Polymorphic Human Telomeric G-Quadruplex Structures

(2015) Michael Sproviero et al.   ACS Chemical Biology

A fluorescent G-quadruplex probe for the assay of base excision repair enzyme activity

(2015) Chang Yeol Lee et al.   CHEMICAL COMMUNICATIONS

Polymerase synthesis of DNA labelled with benzylidene cyanoacetamide-based fluorescent molecular rotors: fluorescent light-up probes for DNA-binding proteins

(2015) Dmytro Dziuba et al.   CHEMICAL COMMUNICATIONS

Dual fluorescent deoxyguanosine mimics for FRET detection of G-quadruplex folding

(2015) Darian J. M. Blanchard et al.   CHEMICAL COMMUNICATIONS

Chlorine Functionalization of a Model Phenolic C8-Guanine Adduct Increases Conformational Rigidity and Blocks Extension by a Y-Family DNA Polymerase

(2015) Aaron A. Witham et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Enhancing Bulge Stabilization through Linear Extension of C8-Aryl-Guanine Adducts to Promote Polymerase Blockage or Strand Realignment to Produce a C:C Mismatch

(2015) Michael Sproviero et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Influence of the Linkage Type and Functional Groups in the Carcinogenic Moiety on the Conformational Preferences of Damaged DNA: Structural and Energetic Characterization of Carbon- and Oxygen-Linked C8-Phenolic-Guanine Adducts

(2015) Purshotam Sharma et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Chlorine substitution promotes phenyl radical loss from C8-phenoxy-2′-deoxyguanosine adducts: implications for biomarker identification from chlorophenol exposure

(2015) Aaron A. Witham et al.   JOURNAL OF MASS SPECTROMETRY

Fluorescent Probe for Proton-Coupled DNA Folding Revealing Slow Exchange of i-Motif and Duplex Structures

(2015) Guillaume Mata et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

5-Formylcytosine can be a stable DNA modification in mammals

(2015) Martin Bachman et al.   Nature Chemical Biology

The NEIL glycosylases remove oxidized guanine lesions from telomeric and promoter quadruplex DNA structures

(2015) Jia Zhou et al.   NUCLEIC ACIDS RESEARCH

Scaffolding along Nucleic Acid Duplexes Using 2′-Amino-Locked Nucleic Acids

(2014) I. Kira Astakhova et al.   ACCOUNTS OF CHEMICAL RESEARCH

Harnessing G-tetrad scaffolds within G-quadruplex forming aptamers for fluorescence detection strategies

(2014) Michael Sproviero et al.   CHEMICAL COMMUNICATIONS

Single C8-Arylguanine Modifications Render Oligonucleotides in the Z-DNA Conformation under Physiological Conditions

(2014) Brian C. Train et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Existence and consequences of G-quadruplex structures in DNA

(2014) Pierre Murat et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Utility of 5′-O-2,7-Dimethylpixyl for Solid-Phase Synthesis of Oligonucleotides Containing Acid-Sensitive 8-Aryl-Guanine Adducts

(2014) Michael Sproviero et al.   JOURNAL OF ORGANIC CHEMISTRY

Structural and biochemical impact of C8-aryl-guanine adducts within the NarI recognition DNA sequence: influence of aryl ring size on targeted and semi-targeted mutagenicity

(2014) Michael Sproviero et al.   NUCLEIC ACIDS RESEARCH

Structural and energetic characterization of the major DNA adduct formed from the food mutagen ochratoxin A in the NarI hotspot sequence: influence of adduct ionization on the conformational preferences and implications for the NER propensity

(2014) Purshotam Sharma et al.   NUCLEIC ACIDS RESEARCH

Abasic site-binding ligands conjugated with cyanine dyes for “off–on” fluorescence sensing of orphan nucleobases in DNA duplexes and DNA–RNA hybrids

(2013) Yusuke Sato et al.   CHEMICAL COMMUNICATIONS

Highly emissive deoxyguanosine analogue capable of direct visualization of B–Z transition

(2013) Soyoung Park et al.   CHEMICAL COMMUNICATIONS

DNA Adducts of the Tobacco Carcinogens 2-Amino-9H-pyrido[2,3-b]indole and 4-Aminobiphenyl Are Formed at Environmental Exposure Levels and Persist in Human Hepatocytes

(2013) Gwendoline Nauwelaërs et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Structural Influence of C8-Phenoxy-Guanine in the NarI Recognition DNA Sequence

(2013) Michael S. Kuska et al.   CHEMICAL RESEARCH IN TOXICOLOGY

G-Quadruplex Folds of the Human Telomere Sequence Alter the Site Reactivity and Reaction Pathway of Guanine Oxidation Compared to Duplex DNA

(2013) Aaron M. Fleming et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Insights into the Conformation of Aminofluorene-Deoxyguanine Adduct in a DNA Polymerase Active Site

(2013) Vaidyanathan G. Vaidyanathan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Influence of Chlorine Substitution on the Hydrolytic Stability of Biaryl Ether Nucleoside Adducts Produced by Phenolic Toxins

(2013) Michael S. Kuska et al.   JOURNAL OF ORGANIC CHEMISTRY

Directing Self-Assembly of DNA Nanotubes Using Programmable Seeds

(2013) Abdul M. Mohammed et al.   NANO LETTERS

Quantitative visualization of DNA G-quadruplex structures in human cells

(2013) Giulia Biffi et al.   Nature Chemistry

Electronic tuning of fluorescent 8-aryl-guanine probes for monitoring DNA duplex–quadruplex exchange

(2013) Michael Sproviero et al.   Chemical Science

Combined nucleobase and backbone modifications enhance DNA duplex stability and preserve biocompatibility

(2013) Afaf H. El-Sagheer et al.   Chemical Science

DNA Charge Transport for Sensing and Signaling

(2012) Pamela A. Sontz et al.   ACCOUNTS OF CHEMICAL RESEARCH

p53 Mutagenesis by Benzo[a]pyrene Derived Radical Cations

(2012) Sushmita Sen et al.   CHEMICAL RESEARCH IN TOXICOLOGY

DNA-Multichromophore Systems

(2012) Yin Nah Teo et al.   CHEMICAL REVIEWS

Designing Chemically Modified Oligonucleotides for Targeted Gene Silencing

(2012) Glen F. Deleavey et al.   CHEMISTRY & BIOLOGY

G-quadruplex DNA Aptamers and their Ligands: Structure, Function and Application

(2012) W. O. Tucker et al.   CURRENT PHARMACEUTICAL DESIGN

Selection, Characterization, and Biosensing Application of High Affinity Congener-Specific Microcystin-Targeting Aptamers

(2012) Andy Ng et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

C8-Heteroaryl-2′-deoxyguanosine Adducts as Conformational Fluorescent Probes in the NarI Recognition Sequence

(2012) Katherine M. Rankin et al.   JOURNAL OF ORGANIC CHEMISTRY

Application of a Fluorescent C-Linked Phenolic Purine Adduct for Selective N7-Metalation of DNA

(2012) Alireza Omumi et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Structural Context Effects in the Oxidation of 8-Oxo-7,8-dihydro-2′-deoxyguanosine to Hydantoin Products: Electrostatics, Base Stacking, and Base Pairing

(2012) Aaron M. Fleming et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nucleotide excision repair of 2-acetylaminofluorene- and 2-aminofluorene-(C8)-guanine adducts: molecular dynamics simulations elucidate how lesion structure and base sequence context impact repair efficiencies

(2012) Hong Mu et al.   NUCLEIC ACIDS RESEARCH

The Role of Methylation in the Intrinsic Dynamics of B- and Z-DNA

(2012) Nuri A. Temiz et al.   PLoS One

Effects of p53 knockout on ochratoxin A-induced genotoxicity in p53-deficient gpt delta mice

(2012) Daisuke Hibi et al.   TOXICOLOGY

8-Vinyl-2′-deoxyguanosine as a Fluorescent 2′-Deoxyguanosine Mimic for Investigating DNA Hybridization and Topology

(2011) André Nadler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Fluorescent Properties and Conformational Preferences of C-Linked Phenolic-DNA Adducts

(2011) Alireza Omumi et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Metabolism and Biomarkers of Heterocyclic Aromatic Amines in Molecular Epidemiology Studies: Lessons Learned from Aromatic Amines

(2011) Robert J. Turesky et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Fluorescent DNA-based enzyme sensors

(2011) Nan Dai et al.   CHEMICAL SOCIETY REVIEWS

Site-Specific Control of N7-Metal Coordination in DNA by a Fluorescent Purine Derivative

(2011) Anaëlle Dumas et al.   CHEMISTRY-A EUROPEAN JOURNAL

Design and Characterization of 1D Nanotubes and 2D Periodic Arrays Self-Assembled from DNA Multi-Helix Bundles

(2011) Tong Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Highly fluorescent guanosine mimics for folding and energy transfer studies

(2011) Anaëlle Dumas et al.   NUCLEIC ACIDS RESEARCH

Further Optimization of Detritylation in Solid-Phase Oligodeoxyribonucleotide Synthesis

(2011) Kha Tram et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

The conformational effect of para-substituted C8-arylguanine adducts on the B/Z-DNA equilibrium

(2010) Vorasit Vongsutilers et al.   BIOPHYSICAL CHEMISTRY

Pyrrolo-dC based fluorescent aptasensors for the molecular recognition of targets

(2010) Taihua Li et al.   CHEMICAL COMMUNICATIONS

Fluorescent Analogs of Biomolecular Building Blocks: Design, Properties, and Applications

(2010) Renatus W. Sinkeldam et al.   CHEMICAL REVIEWS

Conformational Flexibility of C8-Phenoxyl-2′-deoxyguanosine Nucleotide Adducts

(2010) Andrea L. Millen et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Effect of Watson−Crick and Hoogsteen Base Pairing on the Conformational Stability of C8-Phenoxyl-2′-deoxyguanosine Adducts

(2010) Andrea L. Millen et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Cation-Mediated Energy Transfer in G-Quadruplexes Revealed by an Internal Fluorescent Probe

(2010) Anaëlle Dumas et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Hydration Is a Major Determinant of the G-Quadruplex Stability and Conformation of the Human Telomere 3′ Sequence of d(AG3(TTAG3)3)

(2010) M. Clarke Miller et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Postsynthetic Guanine Arylation of DNA by Suzuki−Miyaura Cross-Coupling

(2010) Alireza Omumi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mechanism of error-free and semitargeted mutagenic bypass of an aromatic amine lesion by Y-family polymerase Dpo4

(2010) Olga Rechkoblit et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Fluorescent nucleic acid base analogues

(2010) L. Marcus Wilhelmsson   QUARTERLY REVIEWS OF BIOPHYSICS

Structures of Covalent Adducts between DNA and Ochratoxin A: A New Factor in Debate about Genotoxicity and Human Risk Assessment

(2009) Peter G. Mantle et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Concerning the Hydrolytic Stability of 8-Aryl-2′-deoxyguanosine Nucleoside Adducts: Implications for Abasic Site Formation at Physiological pH

(2009) Katherine M. Schlitt et al.   JOURNAL OF ORGANIC CHEMISTRY

Nucleic Acid Base Analog FRET-Pair Facilitating Detailed Structural Measurements in Nucleic Acid Containing Systems

(2009) Karl Börjesson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An Emissive C Analog Distinguishes between G, 8-oxoG, and T

(2009) Nicholas J. Greco et al.   ORGANIC LETTERS

A Highly Emissive Fluorescent Nucleoside that Signals the Activity of Toxic Ribosome-Inactivating Proteins

(2008) Seergazhi G. Srivatsan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Postsynthetic DNA Modification through the Copper-Catalyzed Azide-Alkyne Cycloaddition Reaction

(2008) Philipp M. E. Gramlich et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Single base interrogation by a fluorescent nucleotide: each of the four DNA bases identified by fluorescence spectroscopy

(2008) Pavol Cekan et al.   CHEMICAL COMMUNICATIONS

Computational and Experimental Evidence for the Structural Preference of Phenolic C-8 Purine Adducts

(2008) Andrea L. Millen et al.   JOURNAL OF PHYSICAL CHEMISTRY A

Oxidation of a Biomarker for Phenol Carcinogen Exposure: Expanding the Redox Chemistry of 2′-Deoxyguanosine

(2008) Jennifer L. Weishar et al.   ORGANIC LETTERS

Lesion processing: high-fidelity versus lesion-bypass DNA polymerases

(2008) Suse Broyde et al.   TRENDS IN BIOCHEMICAL SCIENCES