Structural and biochemical impact of C8-aryl-guanine adducts within the NarI recognition DNA sequence: influence of aryl ring size on targeted and semi-targeted mutagenicity

Conformational Insights into the Lesion and Sequence Effects for Arylamine-Induced Translesion DNA Synthesis: 19F NMR, Surface Plasmon Resonance, and Primer Kinetic Studies

(2014) Vipin Jain et al.   BIOCHEMISTRY

Harnessing G-tetrad scaffolds within G-quadruplex forming aptamers for fluorescence detection strategies

(2014) Michael Sproviero et al.   CHEMICAL COMMUNICATIONS

Single C8-Arylguanine Modifications Render Oligonucleotides in the Z-DNA Conformation under Physiological Conditions

(2014) Brian C. Train et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Utility of 5′-O-2,7-Dimethylpixyl for Solid-Phase Synthesis of Oligonucleotides Containing Acid-Sensitive 8-Aryl-Guanine Adducts

(2014) Michael Sproviero et al.   JOURNAL OF ORGANIC CHEMISTRY

Structural and energetic characterization of the major DNA adduct formed from the food mutagen ochratoxin A in the NarI hotspot sequence: influence of adduct ionization on the conformational preferences and implications for the NER propensity

(2014) Purshotam Sharma et al.   NUCLEIC ACIDS RESEARCH

Structural Mechanism of Replication Stalling on a Bulky Amino-Polycyclic Aromatic Hydrocarbon DNA Adduct by a Y Family DNA Polymerase

(2013) Kevin N. Kirouac et al.   JOURNAL OF MOLECULAR BIOLOGY

Molecular mechanisms underlying ochratoxin A-induced genotoxicity: global gene expression analysis suggests induction of DNA double-strand breaks and cell cycle progression

(2013) Daisuke Hibi et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Electronic tuning of fluorescent 8-aryl-guanine probes for monitoring DNA duplex–quadruplex exchange

(2013) Michael Sproviero et al.   Chemical Science

p53 Mutagenesis by Benzo[a]pyrene Derived Radical Cations

(2012) Sushmita Sen et al.   CHEMICAL RESEARCH IN TOXICOLOGY

MMPBSA.py: An Efficient Program for End-State Free Energy Calculations

(2012) Bill R. Miller et al.   Journal of Chemical Theory and Computation

C8-Heteroaryl-2′-deoxyguanosine Adducts as Conformational Fluorescent Probes in the NarI Recognition Sequence

(2012) Katherine M. Rankin et al.   JOURNAL OF ORGANIC CHEMISTRY

Nucleotide excision repair of 2-acetylaminofluorene- and 2-aminofluorene-(C8)-guanine adducts: molecular dynamics simulations elucidate how lesion structure and base sequence context impact repair efficiencies

(2012) Hong Mu et al.   NUCLEIC ACIDS RESEARCH

Unusual sequence effects on nucleotide excision repair of arylamine lesions: DNA bending/distortion as a primary recognition factor

(2012) Vipin Jain et al.   NUCLEIC ACIDS RESEARCH

Effects of p53 knockout on ochratoxin A-induced genotoxicity in p53-deficient gpt delta mice

(2012) Daisuke Hibi et al.   TOXICOLOGY

Mechanisms of Chemical Carcinogenicity and Mutagenicity: A Review with Implications for Predictive Toxicology

(2011) Romualdo Benigni et al.   CHEMICAL REVIEWS

Site-Specific In Vivo Mutagenicity in the Kidney of gpt Delta Rats Given a Carcinogenic Dose of Ochratoxin A

(2011) Daisuke Hibi et al.   TOXICOLOGICAL SCIENCES

Fluorescent Analogs of Biomolecular Building Blocks: Design, Properties, and Applications

(2010) Renatus W. Sinkeldam et al.   CHEMICAL REVIEWS

Postsynthetic Guanine Arylation of DNA by Suzuki−Miyaura Cross-Coupling

(2010) Alireza Omumi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mechanism of error-free and semitargeted mutagenic bypass of an aromatic amine lesion by Y-family polymerase Dpo4

(2010) Olga Rechkoblit et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The R.E.D. tools: advances in RESP and ESP charge derivation and force field library building

(2010) François-Yves Dupradeau et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Mechanism of replication blocking and bypass of Y-family polymerase   by bulky acetylaminofluorene DNA adducts

(2010) S. Schorr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures of Covalent Adducts between DNA and Ochratoxin A: A New Factor in Debate about Genotoxicity and Human Risk Assessment

(2009) Peter G. Mantle et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Concerning the Hydrolytic Stability of 8-Aryl-2′-deoxyguanosine Nucleoside Adducts: Implications for Abasic Site Formation at Physiological pH

(2009) Katherine M. Schlitt et al.   JOURNAL OF ORGANIC CHEMISTRY

Influence of flanking sequence context on the conformational flexibility of aminofluorene-modified dG adduct in dA mismatch DNA duplexes

(2009) Nidhi Jain et al.   NUCLEIC ACIDS RESEARCH

Computational and Experimental Evidence for the Structural Preference of Phenolic C-8 Purine Adducts

(2008) Andrea L. Millen et al.   JOURNAL OF PHYSICAL CHEMISTRY A

Lesion processing: high-fidelity versus lesion-bypass DNA polymerases

(2008) Suse Broyde et al.   TRENDS IN BIOCHEMICAL SCIENCES