An effective strategy for recapitulating N-terminal heptad repeat trimers in enveloped virus surface glycoproteins for therapeutic applications

Broad-spectrum antivirals against viral fusion

(2015) Frederic Vigant et al.   NATURE REVIEWS MICROBIOLOGY

De novo design of isopeptide bond-tethered triple-stranded coiled coils with exceptional resistance to unfolding and proteolysis: implication for developing antiviral therapeutics

(2015) Chao Wang et al.   Chemical Science

Single-chain protein mimetics of the N-terminal heptad-repeat region of gp41 with potential as anti–HIV-1 drugs

(2014) Sara Crespillo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Design and characterization of ebolavirus GP prehairpin intermediate mimics as drug targets

(2014) Tracy R. Clinton et al.   PROTEIN SCIENCE

An engineered HIV-1 gp41 trimeric coiled coil with increased stability and anti-HIV-1 activity: implication for developing anti-HIV microbicides

(2013) P. Tong et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Design, Synthesis, and Biological Evaluation of Highly Potent Small Molecule–Peptide Conjugates as New HIV-1 Fusion Inhibitors

(2013) Chao Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

HIV-1 variants with a single-point mutation in the gp41 pocket region exhibiting different susceptibility to HIV fusion inhibitors with pocket- or membrane-binding domain

(2012) Lu Lu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Interactions between different generation HIV-1 fusion inhibitors and the putative mechanism underlying the synergistic anti-HIV-1 effect resulting from their combination

(2011) Lifeng Cai et al.   FASEB JOURNAL

Development of Peptide and Small-Molecule HIV-1 Fusion Inhibitors that Target gp41

(2010) Lifeng Cai et al.   ChemMedChem

Enfuvirtide: from basic investigations to current clinical use

(2010) Véronique Joly et al.   EXPERT OPINION ON PHARMACOTHERAPY

Novel Recombinant Engineered gp41 N-terminal Heptad Repeat Trimers and Their Potential as Anti-HIV-1 Therapeutics or Microbicides

(2010) Xi Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modulating Oxytocin Activity and Plasma Stability by Disulfide Bond Engineering

(2010) Markus Muttenthaler et al.   JOURNAL OF MEDICINAL CHEMISTRY

Vaccination with peptide mimetics of the gp41 prehairpin fusion intermediate yields neutralizing antisera against HIV-1 isolates

(2010) E. Bianchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intramolecular isopeptide bonds: protein crosslinks built for stress?

(2010) Hae Joo Kang et al.   TRENDS IN BIOCHEMICAL SCIENCES