Article
Chemistry, Physical
Ting Yang, Huiyun Xu, Yong Zhou, Ying Zhang, Caifen Wang, Abid Naeem, Wenting Wu, Jiwen Zhang, Li Wu, Tao Guo
Summary: In this study, the diffusion coefficient of alpha-lipoic acid (LA) in gamma-cyclodextrin metal-organic framework (CD-MOF) crystals was determined using mathematical modeling and new experimental measurements. The adhesion force between LA and the dicyclodextrin cavity in the CD-MOF was identified as chemisorption dominated by hydrogen binding. It was discovered that the stability enhancement of LA in CD-MOF was due to the combined actions of the high binding free energy and steric hindrance.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Biotechnology & Applied Microbiology
Xujie Liu, Yang Wang, Jiongpeng Yuan, Xiaojing Li, Siwei Wu, Ying Bao, Zhenzhen Feng, Feilong Ou, Yan He
Summary: Machine learning technologies were applied to predict the drug loading capacity of metal-organic frameworks (MOFs). A comprehensive dataset was gathered, and various machine learning algorithms were employed to achieve accurate predictions. The methodology showed promising potential for wide applications.
BIOENGINEERING-BASEL
(2022)
Article
Chemistry, Medicinal
Carina Luengo, Maria C. Crescitelli, Nicolas A. Lopez, Marcelo J. Avena
Summary: This study investigates the effect of drug structure and ionization degree on the formation and properties of biocompatible layered double hydroxides (LDH) intercalated with ibuprofen and paracetamol. It was found that ibuprofen intercalation was efficient while paracetamol intercalation was poor. The dissolution kinetics of LDHs was highly pH-dependent, while the drug release kinetics were influenced by both pH and buffer type in physiological buffers.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Quanying Bao, Suraj Fanse, Xiaoyu (James) Lu, Diane J. Burgess
Summary: This study investigates the impact of drug loading on the release of Levonorgestrel intrauterine systems (LNG-IUSs) by preparing drug reservoirs with different drug loading and conducting release testing under accelerated conditions. The results show that the release rate of LNG-IUSs is inversely proportional to the drug loading. Low drug loading leads to incomplete drug release or even no drug release at all. Accelerated release testing methods are found to be representative of real-time release profiles, providing confidence in extending the duration of usage for these products as long as the device remains intact and the release rate is within the therapeutic window.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Mengru Cai, Yawen Zeng, Manting Liu, Longtai You, Huating Huang, Yang Hao, Xingbin Yin, Changhai Qu, Jian Ni, Xiaoxv Dong
Summary: This study constructed a functionalized nano-platform for the targeted delivery of the anti-tumor drug triptolide and achieved in vivo fluorescence imaging. The functionalized nanoparticles showed better targeted therapy efficiency and reduced the systemic toxicity of triptolide.
Article
Chemistry, Applied
Yulu Chen, Kedong Tai, Peihua Ma, Jiaqi Su, Wenxia Dong, Yanxiang Gao, Like Mao, Jinfang Liu, Fang Yuan
Summary: A safe and biodegradable gamma-cyclodextrin-metal-organic-frameworks (gamma-CD-MOFs) was successfully synthesized and tested for curcumin encapsulation stability and release performance. Results show that gamma-CD-MOFs can be regarded as promising carriers for the delivery of curcumin or other hydrophobic nutraceuticals.
Article
Chemistry, Multidisciplinary
C. Bassand, F. Siepmann, L. Benabed, J. Verin, J. Freitag, S. Charlon, J. Soulestin, J. Siepmann
Summary: Different types of ibuprofen-loaded, poly (D,L lactic-co-glycolic acid) (PLGA)-based implants were prepared by 3D printing. The effect of filling density on drug release was investigated and it was found that filling density significantly influenced the release kinetics and the shape of the release curve. This can be explained by the presence (or absence) of a continuous aqueous phase between the polymeric filaments and the role of substantial system swelling in controlling drug release.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Physical
Ceren Atila Dincer, Bengu Getiren, Ceren Gokalp, Zafer Ciplak, Ayse Karakecili, Nuray Yildiz
Summary: Photothermal therapy (PTT) is a promising new approach for cancer treatment that utilizes nanocomposites with superior photo thermal and magnetic properties. This study demonstrates that NIR-triggered DOX release from the nanocomposites can significantly enhance the cytotoxic effects on cancer cells, indicating great potential for photothermal chemotherapy.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Pharmacology & Pharmacy
Xinran Zhang, Li Yin Chau, Ho Wan Chan, Jingwen Weng, Ka Wai Wong, Shing Fung Chow, Albert Hee Lum Chow
Summary: The study successfully prepared polymeric IBP nanoparticles using flash nanoprecipitation technology, and found that the nanoparticles could enhance the delivery of IBP into the brain. However, some nanoparticles may face the issue of rapid release into the bloodstream following intravenous administration.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Biochemistry & Molecular Biology
Matin Rostamitabar, Abdelrahman M. Abdelgawad, Stefan Jockenhoevel, Samaneh Ghazanfari
Summary: Drug-eluting medical textiles have attracted great attention for their cost effectiveness and unique physical and chemical properties, and are being widely used in various applications. Through different fiber production and textile fabrication technologies, fibrous constructs with required properties can be designed and fabricated. Current advances in manufacturing techniques and applications are moving towards more diversified and refined directions.
MACROMOLECULAR BIOSCIENCE
(2021)
Article
Biochemical Research Methods
Hytham Hassan, Rama Alqassar Bani Almarjeh, Yomen Atassi
Summary: This study investigated the loading capacity of nitrogen-doped carbon quantum dots encapsulated using sodium alginate. The optimal release conditions were found to be at 40 degrees Celsius and a pH simulating the duodenum. These Ibuprofen-loaded CQDs capsules show promise for drug release and bioimaging applications.
JOURNAL OF FLUORESCENCE
(2021)
Article
Pharmacology & Pharmacy
O. Cantin, F. Siepmann, J. F. Willart, F. Danede, J. Siepmann, Y. Karrout
Summary: A study prepared matrix tablets with different drug loadings and PEO molecular weights via hot melt extrusion. The release rates of metoprolol tartrate increased monotonically with initial drug loading, while the release rates of theophylline and ibuprofen were influenced by drug solubility effects and varied with different PEO molecular weights.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ana Ciric, Dorde Medarevic, Bojan Calija, Vladimir Dobricic, Milena Rmandic, Tanja Barudzija, Andelija Malenovic, Ljiljana Djekic
Summary: The entrapment procedure of a poorly water soluble drug was studied to investigate its effect on the physicochemical and drug release performances of chitosan/xanthan polyelectrolyte complexes (PECs). Different drug entrapment procedures and chitosan-to-xanthan mass ratios were observed to affect the formation of PECs, leading to controlled drug release with zero-order kinetics.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Muhammad Umar Aslam Khan, Saiful Izwan Abd Razak, Sajjad Haider, Hafiz Abdul Mannan, Javed Hussain, Anarwul Hasan
Summary: Biopolymer-based composite hydrogels have shown great potential for tissue regeneration and antitumor applications, with excellent drug release properties and biocompatibility.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Pharmacology & Pharmacy
C. Bassand, J. Freitag, L. Benabed, J. Verin, F. Siepmann, J. Siepmann
Summary: The aim of this study was to investigate the importance of the diameter of PLGA-based implants on drug release. The results showed that increasing the implant diameter led to a decrease in drug release rates. The drug exhibited a biphasic release pattern, with a zero-order release followed by a rapid release phase. Increasing the implant diameter also delayed the onset of the rapid release phase.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2022)
