Peptidyl Prolyl Isomerase PIN1 Directly Binds to and Stabilizes Hypoxia-Inducible Factor-1α

Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer

(2015) Shuo Wei et al.   NATURE MEDICINE

Pin1 inhibits PP2A-mediated Rb dephosphorylation in regulation of cell cycle and S-phase DNA damage

(2015) Y Tong et al.   Cell Death & Disease

The prolyl isomerase Pin1 regulates hypoxia-inducible transcription factor (HIF) activity

(2014) Maroua Jalouli et al.   CELLULAR SIGNALLING

Pin1, a new player in the fate of HIF-1α degradation: an hypothetical mechanism inside vascular damage as Alzheimer’s disease risk factor

(2014) Elena Lonati et al.   Frontiers in Cellular Neuroscience

Structural and functional analysis of the related transcriptional enhancer factor-1 and NF-κB interaction

(2013) Jieliang Ma et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

CDK1 stabilizes HIF-1α via direct phosphorylation of Ser668 to promote tumor growth

(2013) Noel A Warfel et al.   CELL CYCLE

Focusing on the structure and the function of Pin1: New insights into the opposite effects of fever on cancers and Alzheimer’s disease

(2013) Jing-Zhang Wang et al.   MEDICAL HYPOTHESES

Decursin Exerts Anti-cancer Activity in MDA-MB-231 Breast Cancer Cells Via Inhibition of the Pin1 Activity and Enhancement of the Pin1/p53 Association

(2013) Ji-Hyun Kim et al.   PHYTOTHERAPY RESEARCH

The prolyl-isomerase Pin1 activates the mitochondrial death program of p53

(2012) G Sorrentino et al.   CELL DEATH AND DIFFERENTIATION

Critical Role of Hypoxia Sensor - HIF-1α in VEGF Gene Activation. Implications for Angiogenesis and Tissue Injury Healing

(2012) A. Ahluwalia et al.   CURRENT MEDICINAL CHEMISTRY

Prolyl Isomerase Pin1 Regulates Neuronal Differentiation via  -Catenin

(2012) K. Nakamura et al.   MOLECULAR AND CELLULAR BIOLOGY

Negative Regulation of the Stability and Tumor Suppressor Function of Fbw7 by the Pin1 Prolyl Isomerase

(2012) Sang-Hyun Min et al.   MOLECULAR CELL

A Cullin3-KLHL20 Ubiquitin Ligase-Dependent Pathway Targets PML to Potentiate HIF-1 Signaling and Prostate Cancer Progression

(2011) Wei-Chien Yuan et al.   CANCER CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Essential role for the prolyl isomerase Pin1 in Toll-like receptor signaling and type I interferon–mediated immunity

(2011) Adrian Tun-Kyi et al.   NATURE IMMUNOLOGY

Prolyl isomerase Pin1 as a molecular switch to determine the fate of phosphoproteins

(2011) Yih-Cherng Liou et al.   TRENDS IN BIOCHEMICAL SCIENCES

Hypoxia and Hypoxia-Inducible Factors: Master Regulators of Metastasis

(2010) X. Lu et al.   CLINICAL CANCER RESEARCH

Plk3 Functions as an Essential Component of the Hypoxia Regulatory Pathway by Direct Phosphorylation of HIF-1α

(2010) Dazhong Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pin1 Catalyzes Conformational Changes of Thr-187 in p27Kip1and Mediates Its Stability through a Polyubiquitination Process

(2009) Wei Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In Vivo Bioluminescence Imaging Monitoring of Hypoxia-Inducible Factor 1α, a Promoter That Protects Cells, in Response to Chemotherapy

(2008) Ronald J. Viola et al.   AMERICAN JOURNAL OF ROENTGENOLOGY