Focal adhesion kinase

Targeting FAK in human cancer: from finding to first clinical trials

(2014) Vita Golubovskaya   Frontiers in Bioscience-Landmark

Tumour angiogenesis regulation by the miR-200 family

(2013) Chad V. Pecot et al.   Nature Communications

Turning promise into progress for antiangiogenic agents in epithelial ovarian cancer

(2012) Arne R.M. van der Bilt et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Safety, Pharmacokinetic, and Pharmacodynamic Phase I Dose-Escalation Trial of PF-00562271, an Inhibitor of Focal Adhesion Kinase, in Advanced Solid Tumors

(2012) Jeffrey R. Infante et al.   JOURNAL OF CLINICAL ONCOLOGY

Abstract A249: BI 853520, a potent and highly selective inhibitor of protein tyrosine kinase 2 (focal adhesion kinase), shows efficacy in multiple xenograft models of human cancer.

(2012) U. A. Hirt et al.   MOLECULAR CANCER THERAPEUTICS

Focal Adhesion Kinase as a Cancer Therapy Target

(2011) Vita M. Golubovskaya   Anti-Cancer Agents in Medicinal Chemistry

Inhibition of angiogenesis and the angiogenesis/invasion shift

(2011) Andreas Bikfalvi et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The impact of disease distribution on survival in patients with stage III epithelial ovarian cancer cytoreduced to microscopic residual: A gynecologic oncology group study

(2011) Chad A. Hamilton et al.   GYNECOLOGIC ONCOLOGY

Moving Beyond Anti–Vascular Endothelial Growth Factor Therapy in Ovarian Cancer

(2011) Anil K. Sood et al.   JOURNAL OF CLINICAL ONCOLOGY

Ovarian Cancer Genome Sequencing Unveils Findings

(2011) V. Brower   JNCI-Journal of the National Cancer Institute

Endothelial FAK is required for tumour angiogenesis

(2010) Bernardo Tavora et al.   EMBO Molecular Medicine

Therapeutic potential and limitations of new FAK inhibitors in the treatment of cancer

(2010) Alexander Schultze et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Stress Effects on FosB- and Interleukin-8 (IL8)-driven Ovarian Cancer Growth and Metastasis

(2010) Mian M. K. Shahzad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antiangiogenic Therapy Elicits Malignant Progression of Tumors to Increased Local Invasion and Distant Metastasis

(2009) Marta Pàez-Ribes et al.   CANCER CELL

Tumor and Host-Mediated Pathways of Resistance and Disease Progression in Response to Antiangiogenic Therapy

(2009) J. M. L. Ebos et al.   CLINICAL CANCER RESEARCH

Targeting focal adhesion kinase signaling in tumor growth and metastasis

(2009) Joerg Schwock et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Antitumor Activity and Pharmacology of a Selective Focal Adhesion Kinase Inhibitor, PF-562,271

(2008) W. G. Roberts et al.   CANCER RESEARCH

A Small Molecule Inhibitor, 1,2,4,5-Benzenetetraamine Tetrahydrochloride, Targeting the Y397 Site of Focal Adhesion Kinase Decreases Tumor Growth

(2008) Vita M. Golubovskaya et al.   JOURNAL OF MEDICINAL CHEMISTRY