Inhibition of focal adhesion kinase (FAK) activity prevents anchorage-independent ovarian carcinoma cell growth and tumor progression

FERM control of FAK function: Implications for cancer therapy

(2014) Ssang-Taek Lim et al.   CELL CYCLE

Cancer statistics, 2012

(2012) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

The Changing View of High-Grade Serous Ovarian Cancer

(2012) E. M. J. J. Berns et al.   CANCER RESEARCH

Subcutaneous passage increases cell aggressiveness in a xenograft model of diffuse large B cell lymphoma

(2012) Rosa Bosch et al.   CLINICAL & EXPERIMENTAL METASTASIS

Inflammation and ovarian cancer

(2012) Antonio Macciò et al.   CYTOKINE

VEGF-Induced Vascular Permeability Is Mediated by FAK

(2012) Xiao Lei Chen et al.   DEVELOPMENTAL CELL

Implementing an online tool for genome-wide validation of survival-associated biomarkers in ovarian-cancer using microarray data from 1287 patients

(2012) Balázs Győrffy et al.   ENDOCRINE-RELATED CANCER

Phase II evaluation of dasatinib in the treatment of recurrent or persistent epithelial ovarian or primary peritoneal carcinoma: A Gynecologic Oncology Group study

(2012) Russell J. Schilder et al.   GYNECOLOGIC ONCOLOGY

Nuclear-localized focal adhesion kinase regulates inflammatory VCAM-1 expression

(2012) Ssang-Taek Lim et al.   JOURNAL OF CELL BIOLOGY

Safety, Pharmacokinetic, and Pharmacodynamic Phase I Dose-Escalation Trial of PF-00562271, an Inhibitor of Focal Adhesion Kinase, in Advanced Solid Tumors

(2012) Jeffrey R. Infante et al.   JOURNAL OF CLINICAL ONCOLOGY

The role of focal adhesion kinase catalytic activity on the proliferation and migration of squamous cell carcinoma cells

(2011) Alan Serrels et al.   INTERNATIONAL JOURNAL OF CANCER

Inhibition of Focal Adhesion Kinase by PF-562,271 Inhibits the Growth and Metastasis of Pancreatic Cancer Concomitant with Altering the Tumor Microenvironment

(2011) J. B. Stokes et al.   MOLECULAR CANCER THERAPEUTICS

Focal adhesion kinase inhibitors are potent anti-angiogenic agents

(2011) Miguel A. Cabrita et al.   Molecular Oncology

Integrated genomic analyses of ovarian carcinoma

(2011) D. Bell et al.   NATURE

Autophagic targeting of Src promotes cancer cell survival following reduced FAK signalling

(2011) Emma Sandilands et al.   NATURE CELL BIOLOGY

Integrin Inhibitors as a Therapeutic Agent for Ovarian Cancer

(2011) Kenjiro Sawada et al.   Journal of Oncology

Ovarian Cancer Development and Metastasis

(2010) Ernst Lengyel   AMERICAN JOURNAL OF PATHOLOGY

Sunitinib and PF-562,271 (FAK/Pyk2 inhibitor) effectively block growth and recovery of human hepatocellular carcinoma in a rat xenograft model

(2010) Cedo M Bagi et al.   CANCER BIOLOGY & THERAPY

Bioluminescent imaging study

(2010) Haihao Sun et al.   CANCER BIOLOGY & THERAPY

PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments

(2010) Isabelle Tanjoni et al.   CANCER BIOLOGY & THERAPY

Oral delivery of PND-1186 FAK inhibitor decreases tumor growth and spontaneous breast to lung metastasis in pre-clinical models

(2010) Colin Walsh et al.   CANCER BIOLOGY & THERAPY

Therapeutic potential and limitations of new FAK inhibitors in the treatment of cancer

(2010) Alexander Schultze et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Knock-in Mutation Reveals an Essential Role for Focal Adhesion Kinase Activity in Blood Vessel Morphogenesis and Cell Motility-Polarity but Not Cell Proliferation

(2010) Ssang-Taek Lim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of kinase-independent and -dependent functions of FAK in endothelial cell survival and barrier function during embryonic development

(2010) Xiaofeng Zhao et al.   JOURNAL OF CELL BIOLOGY

Cellular functions of FAK kinases: insight into molecular mechanisms and novel functions

(2010) M. D. Schaller   JOURNAL OF CELL SCIENCE

Adrenergic modulation of focal adhesion kinase protects human ovarian cancer cells from anoikis

(2010) Anil K. Sood et al.   JOURNAL OF CLINICAL INVESTIGATION

A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24

(2010) Ellen L Goode et al.   NATURE GENETICS

Signal transduction by focal adhesion kinase in cancer

(2009) Jihe Zhao et al.   CANCER AND METASTASIS REVIEWS

Mammary Epithelial-Specific Ablation of the Focal Adhesion Kinase Suppresses Mammary Tumorigenesis by Affecting Mammary Cancer Stem/Progenitor Cells

(2009) M. Luo et al.   CANCER RESEARCH

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

Multicellular spheroids in ovarian cancer metastases: Biology and pathology

(2009) Kristy Shield et al.   GYNECOLOGIC ONCOLOGY

TAE226-mediated inhibition of focal adhesion kinase interferes with tumor angiogenesis and vasculogenesis

(2009) Alexander Schultze et al.   INVESTIGATIONAL NEW DRUGS

Differential requirement for focal adhesion kinase signaling in cancer progression in the transgenic adenocarcinoma of mouse prostate model

(2009) J. K. Slack-Davis et al.   MOLECULAR CANCER THERAPEUTICS

Dual focal adhesion kinase/Pyk2 inhibitor has positive effects on bone tumors

(2008) Cedo M. Bagi et al.   CANCER

Antitumor Activity and Pharmacology of a Selective Focal Adhesion Kinase Inhibitor, PF-562,271

(2008) W. G. Roberts et al.   CANCER RESEARCH

Compensatory role for Pyk2 during angiogenesis in adult mice lacking endothelial cell FAK

(2008) Sara M. Weis et al.   JOURNAL OF CELL BIOLOGY

Early Events in the Pathogenesis of Epithelial Ovarian Cancer

(2008) Charles N. Landen et al.   JOURNAL OF CLINICAL ONCOLOGY

Nuclear FAK Promotes Cell Proliferation and Survival through FERM-Enhanced p53 Degradation

(2008) Ssang-Taek Lim et al.   MOLECULAR CELL

Epithelial–stromal interaction increases cell proliferation, survival and tumorigenicity in a mouse model of human epithelial ovarian cancer

(2007) James Greenaway et al.   GYNECOLOGIC ONCOLOGY