Depletion of the Fragile X Mental Retardation Protein in Embryonic Stem Cells Alters the Kinetics of Neurogenesis

Regional brain volumes changes in adult male FMR1-KO mouse on the FVB strain

(2016) J.K.Y. Lai et al.   NEUROSCIENCE

Hippocampal neuronal subtypes develop abnormal dendritic arbors in the presence of Fragile X astrocytes

(2016) S. Jacobs et al.   NEUROSCIENCE

GABA and glutamate: the Yin and Yang of fragile X

(2015) Michael R Tranfaglia   CELL CYCLE

The quest for targeted therapy in fragile X syndrome

(2015) Shimriet Zeidler et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

HCFC1 loss-of-function mutations disrupt neuronal and neural progenitor cells of the developing brain

(2015) L. A. Jolly et al.   HUMAN MOLECULAR GENETICS

Functional Deficiencies in Fragile X Neurons Derived from Human Embryonic Stem Cells

(2015) M. Telias et al.   JOURNAL OF NEUROSCIENCE

Fragile X disappointments upset autism ambitions

(2015) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Inhibition of GSK3β rescues hippocampal development and learning in a mouse model of CDKL5 disorder

(2015) Claudia Fuchs et al.   NEUROBIOLOGY OF DISEASE

Molecular Mechanisms Regulating Impaired Neurogenesis of Fragile X Syndrome Human Embryonic Stem Cells

(2015) Michael Telias et al.   STEM CELLS AND DEVELOPMENT

Persistent astrocyte activation in the fragile X mouse cerebellum

(2015) Laura K. K. Pacey et al.   Brain and Behavior

Translating Molecular Advances in Fragile X Syndrome Into Therapy

(2014) Randi J. Hagerman et al.   JOURNAL OF CLINICAL PSYCHIATRY

Investigating human disease using stem cell models

(2014) Jared L. Sterneckert et al.   NATURE REVIEWS GENETICS

Ezrin Mediates Neuritogenesis via Down-Regulation of RhoA Activity in Cultured Cortical Neurons

(2014) Yosuke Matsumoto et al.   PLoS One

Promoter-Bound Trinucleotide Repeat mRNA Drives Epigenetic Silencing in Fragile X Syndrome

(2014) D. Colak et al.   SCIENCE

Oxytocin-Mediated GABA Inhibition During Delivery Attenuates Autism Pathogenesis in Rodent Offspring

(2014) R. Tyzio et al.   SCIENCE

ATRX is required for maintenance of the neuroprogenitor cell pool in the embryonic mouse brain

(2014) K. Ritchie et al.   Biology Open

FMR1 Epigenetic Silencing Commonly Occurs in Undifferentiated Fragile X-Affected Embryonic Stem Cells

(2014) Michal Avitzour et al.   Stem Cell Reports

Treating Fragile X syndrome with the diuretic bumetanide: a case report

(2013) Eric Lemonnier et al.   ACTA PAEDIATRICA

Translational Regulation of NeuroD1 Expression by FMRP: Involvement in Glutamatergic Neuronal Differentiation of Cultured Rat Primary Neural Progenitor Cells

(2013) Se Jin Jeon et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Extra-cell cycle regulatory functions of cyclin-dependent kinases (CDK) and CDK inhibitor proteins contribute to brain development and neurological disorders

(2013) Takeshi Kawauchi et al.   GENES TO CELLS

The UPF3B gene, implicated in intellectual disability, autism, ADHD and childhood onset schizophrenia regulates neural progenitor cell behaviour and neuronal outgrowth

(2013) Lachlan A. Jolly et al.   HUMAN MOLECULAR GENETICS

A Novel Role for the RNA–Binding Protein FXR1P in Myoblasts Cell-Cycle Progression by Modulating p21/Cdkn1a/Cip1/Waf1 mRNA Stability

(2013) Laetitia Davidovic et al.   PLoS Genetics

Identification of Transcription Factors for Lineage-Specific ESC Differentiation

(2013) Kohei Yamamizu et al.   Stem Cell Reports

Neural differentiation of fragile X human embryonic stem cells reveals abnormal patterns of development despite successful neurogenesis

(2012) Michael Telias et al.   DEVELOPMENTAL BIOLOGY

Disease Modeling Using Embryonic Stem Cells: MeCP2 Regulates Nuclear Size and RNA Synthesis in Neurons

(2012) Morteza Yazdani et al.   STEM CELLS

A novel function of the proneural factor Ascl1 in progenitor proliferation identified by genome-wide characterization of its targets

(2011) D. S. Castro et al.   GENES & DEVELOPMENT

A metabolomic and systems biology perspective on the brain of the Fragile X syndrome mouse model

(2011) L. Davidovic et al.   GENOME RESEARCH

Soluble Amyloid Precursor Protein Induces Rapid Neural Differentiation of Human Embryonic Stem Cells

(2011) Kristine K. Freude et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FMRP Regulates the Transition from Radial Glial Cells to Intermediate Progenitor Cells during Neocortical Development

(2011) R. Saffary et al.   JOURNAL OF NEUROSCIENCE

Fragile X Mental Retardation Protein Regulates New Neuron Differentiation in the Adult Olfactory Bulb

(2011) S. Scotto-Lomassese et al.   JOURNAL OF NEUROSCIENCE

Reversal of Fragile X Phenotypes by Manipulation of AβPP/Aβ Levels in Fmr1KO Mice

(2011) Cara J. Westmark et al.   PLoS One

Epigenetic Characterization of the FMR1 Gene and Aberrant Neurodevelopment in Human Induced Pluripotent Stem Cell Models of Fragile X Syndrome

(2011) Steven D. Sheridan et al.   PLoS One

Dysregulation of fragile × mental retardation protein and metabotropic glutamate receptor 5 in superior frontal cortex of individuals with autism: a postmortem brain study

(2011) S Hossein Fatemi et al.   Molecular Autism

Differential Modeling of Fragile X Syndrome by Human Embryonic Stem Cells and Induced Pluripotent Stem Cells

(2010) Achia Urbach et al.   Cell Stem Cell

Coffin–Lowry syndrome: A role for RSK2 in mammalian neurogenesis

(2010) Chandrasagar B. Dugani et al.   DEVELOPMENTAL BIOLOGY

The Transcription Factor Cux1 Regulates Dendritic Morphology of Cortical Pyramidal Neurons

(2010) Ning Li et al.   PLoS One

Region-specific alterations in brain development in one- to three-year-old boys with fragile X syndrome

(2010) F. Hoeft et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Early continuous inhibition of group 1 mGlu signaling partially rescues dendritic spine abnormalities in the Fmr1 knockout mouse model for fragile X syndrome

(2010) Tao Su et al.   PSYCHOPHARMACOLOGY

Fragile X Mental Retardation Protein Regulates Proliferation and Differentiation of Adult Neural Stem/Progenitor Cells

(2010) Yuping Luo et al.   PLoS Genetics

Gene, brain, and behavior relationships in fragile X syndrome: Evidence from neuroimaging studies

(2009) Amy A. Lightbody et al.   Developmental Disabilities Research Reviews

Tissue and developmental regulation of fragile X mental retardation 1 exon 12 and 15 isoforms

(2009) Wen Xie et al.   NEUROBIOLOGY OF DISEASE

Zinc Finger Protein 191 (ZNF191/Zfp191) Is Necessary to Maintain Neural Cells As Cycling Progenitors

(2009) Olfa Khalfallah et al.   STEM CELLS

Dax-1 Knockdown in Mouse Embryonic Stem Cells Induces Loss of Pluripotency and Multilineage Differentiation

(2009) Olfa Khalfallah et al.   STEM CELLS

Translational Regulation of the Human Achaete-scute Homologue-1 by Fragile X Mental Retardation Protein

(2008) Michael Fähling et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Circuit and Plasticity Defects in the Developing Somatosensory Cortex of Fmr1 Knock-Out Mice

(2008) I. Bureau et al.   JOURNAL OF NEUROSCIENCE

Aberrant differentiation of glutamatergic cells in neocortex of mouse model for fragile X syndrome

(2008) Topi A. Tervonen et al.   NEUROBIOLOGY OF DISEASE

Fragile X Syndrome: Loss of Local mRNA Regulation Alters Synaptic Development and Function

(2008) Gary J. Bassell et al.   NEURON

Normal Neurogenesis but Abnormal Gene Expression in Human Fragile X Cortical Progenitor Cells

(2008) Anita Bhattacharyya et al.   STEM CELLS AND DEVELOPMENT

Neuroanatomy of fragile X syndrome is associated with aberrant behavior and the fragile X mental retardation protein (FMRP)

(2007) Doron Gothelf et al.   ANNALS OF NEUROLOGY