Disease Modeling Using Embryonic Stem Cells: MeCP2 Regulates Nuclear Size and RNA Synthesis in Neurons

Erosion of Dosage Compensation Impacts Human iPSC Disease Modeling

(2012) Shila Mekhoubad et al.   Cell Stem Cell

Rett syndrome induced pluripotent stem cell-derived neurons reveal novel neurophysiological alterations

(2012) N Farra et al.   MOLECULAR PSYCHIATRY

X-Chromosome Inactivation in Rett Syndrome Human Induced Pluripotent Stem Cells

(2012) Aaron Y. L. Cheung et al.   Frontiers in Psychiatry

Transgenic complementation of MeCP2 deficiency: phenotypic rescue of Mecp2-null mice by isoform-specific transgenes

(2011) Bredford Kerr et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Isolation of MECP2-null Rett Syndrome patient hiPS cells and isogenic controls through X-chromosome inactivation

(2011) Aaron Y.L. Cheung et al.   HUMAN MOLECULAR GENETICS

A role for glia in the progression of Rett’s syndrome

(2011) Daniel T. Lioy et al.   NATURE

MeCP2 is required for global heterochromatic and nucleolar changes during activity-dependent neuronal maturation

(2011) Malaika K. Singleton et al.   NEUROBIOLOGY OF DISEASE

Isogenic Pairs of Wild Type and Mutant Induced Pluripotent Stem Cell (iPSC) Lines from Rett Syndrome Patients as In Vitro Disease Model

(2011) Gene Ananiev et al.   PLoS One

Neuronal maturation defect in induced pluripotent stem cells from patients with Rett syndrome

(2011) K.-Y. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Model for Neural Development and Treatment of Rett Syndrome Using Human Induced Pluripotent Stem Cells

(2010) Maria C.N. Marchetto et al.   CELL

Rett Syndrome Microglia Damage Dendrites and Synapses by the Elevated Release of Glutamate

(2010) I. Maezawa et al.   JOURNAL OF NEUROSCIENCE

Global Deprivation of Brain-Derived Neurotrophic Factor in the CNS Reveals an Area-Specific Requirement for Dendritic Growth

(2010) S. Rauskolb et al.   JOURNAL OF NEUROSCIENCE

Neuronal MeCP2 Is Expressed at Near Histone-Octamer Levels and Globally Alters the Chromatin State

(2010) Peter J. Skene et al.   MOLECULAR CELL

Mouse models of MeCP2 disorders share gene expression changes in the cerebellum and hypothalamus

(2009) Shay Ben-Shachar et al.   HUMAN MOLECULAR GENETICS

Rett Syndrome Astrocytes Are Abnormal and Spread MeCP2 Deficiency through Gap Junctions

(2009) I. Maezawa et al.   JOURNAL OF NEUROSCIENCE

Non–cell autonomous influence of MeCP2-deficient glia on neuronal dendritic morphology

(2009) Nurit Ballas et al.   NATURE NEUROSCIENCE

Nuclear functions in space and time: Gene expression in a dynamic, constrained environment

(2008) Laura Trinkle-Mulcahy et al.   FEBS LETTERS

A partial loss of function allele of Methyl-CpG-binding protein 2 predicts a human neurodevelopmental syndrome

(2008) R. C. Samaco et al.   HUMAN MOLECULAR GENETICS

Biosynthesis and processing of endogenous BDNF: CNS neurons store and secrete BDNF, not pro-BDNF

(2008) Tomoya Matsumoto et al.   NATURE NEUROSCIENCE

MeCP2, a Key Contributor to Neurological Disease, Activates and Represses Transcription

(2008) M. Chahrour et al.   SCIENCE

Dual-promoter lentiviral vectors for constitutive and regulated gene expression in neurons

(2007) Sergio Gascón et al.   JOURNAL OF NEUROSCIENCE METHODS