Embryonic Stem Cells Cultured in Microfluidic Chambers Take Control of Their Fate by Producing Endogenous Signals Including LIF

Resetting Transcription Factor Control Circuitry toward Ground-State Pluripotency in Human

(2014) Yasuhiro Takashima et al.   CELL

Two miRNA Clusters Reveal Alternative Paths in Late-Stage Reprogramming

(2014) Ronald J. Parchem et al.   Cell Stem Cell

Systematic Identification of Culture Conditions for Induction and Maintenance of Naive Human Pluripotency

(2014) Thorold W. Theunissen et al.   Cell Stem Cell

The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification

(2014) Thorsten Boroviak et al.   NATURE CELL BIOLOGY

Local BMP-SMAD1 Signaling Increases LIF Receptor-Dependent STAT3 Responsiveness and Primed-to-Naive Mouse Pluripotent Stem Cell Conversion Frequency

(2014) Kento Onishi et al.   Stem Cell Reports

Induction of a Human Pluripotent State with Distinct Regulatory Circuitry that Resembles Preimplantation Epiblast

(2013) Yun-Shen Chan et al.   Cell Stem Cell

Derivation of novel human ground state naive pluripotent stem cells

(2013) Ohad Gafni et al.   NATURE

Naive pluripotency is associated with global DNA hypomethylation

(2013) Harry G Leitch et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Role of Paracrine and Autocrine Signaling in the Early Phase of Adipogenic Differentiation of Adipose-derived Stem Cells

(2013) Mette Hemmingsen et al.   PLoS One

Probing Embryonic Stem Cell Autocrine and Paracrine Signaling Using Microfluidics

(2012) Laralynne Przybyla et al.   Annual Review of Analytical Chemistry

Microfluidic systems: A new toolbox for pluripotent stem cells

(2012) Sasha Cai Lesher-Perez et al.   Biotechnology Journal

BMP4 Signaling Acts via Dual-Specificity Phosphatase 9 to Control ERK Activity in Mouse Embryonic Stem Cells

(2012) Zhongwei Li et al.   Cell Stem Cell

Microenvironment-mediated reversion of epiblast stem cells by reactivation of repressed JAK–STAT signaling

(2012) Kento Onishi et al.   Integrative Biology

Directed cardiomyocyte differentiation from human pluripotent stem cells by modulating Wnt/β-catenin signaling under fully defined conditions

(2012) Xiaojun Lian et al.   Nature Protocols

Predictive microfluidic control of regulatory ligand trajectories in individual pluripotent cells

(2012) F. Moledina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Attenuation of extrinsic signaling reveals the importance of matrix remodeling on maintenance of embryonic stem cell self-renewal

(2012) L. M. Przybyla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cozzarelli Prize Winner: Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling

(2012) X. Lian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stage-Specific Optimization of Activin/Nodal and BMP Signaling Promotes Cardiac Differentiation of Mouse and Human Pluripotent Stem Cell Lines

(2011) Steven J. Kattman et al.   Cell Stem Cell

Microfluidic Perfusion for Regulating Diffusible Signaling in Stem Cells

(2011) Katarina Blagovic et al.   PLoS One

Naive and primed murine pluripotent stem cells have distinct miRNA expression profiles

(2011) A. Jouneau et al.   RNA

Distinct functions of BMP4 during different stages of mouse ES cell neural commitment

(2010) K. Zhang et al.   DEVELOPMENT

Microfluidic image cytometry for quantitative single-cell profiling of human pluripotent stem cells in chemically defined conditions

(2010) Ken-ichiro Kamei et al.   LAB ON A CHIP

Opposing microRNA families regulate self-renewal in mouse embryonic stem cells

(2010) Collin Melton et al.   NATURE

Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs

(2010) J. Hanna et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kinetic and metabolic analysis of mouse embryonic stem cell expansion under serum-free conditions

(2009) Tiago G. Fernandes et al.   BIOTECHNOLOGY LETTERS

Naive and Primed Pluripotent States

(2009) Jennifer Nichols et al.   Cell Stem Cell

Klf4 reverts developmentally programmed restriction of ground state pluripotency

(2009) G. Guo et al.   DEVELOPMENT

From the cellular perspective: exploring differences in the cellular baseline in macroscale and microfluidic cultures

(2009) Amy L. Paguirigan et al.   Integrative Biology

Computational model and microfluidic platform for the investigation of paracrine and autocrine signaling in mouse embryonic stem cells

(2009) David Ellison et al.   Molecular BioSystems

Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling

(2009) Stuart M Chambers et al.   NATURE BIOTECHNOLOGY

Microwell-mediated control of embryoid body size regulates embryonic stem cell fate via differential expression of WNT5a and WNT11

(2009) Y.-S. Hwang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of oxygen on mouse embryonic stem cell growth, phenotype retention, and cellular energetics

(2008) Daryl E. Powers et al.   BIOTECHNOLOGY AND BIOENGINEERING

An integrated microfluidic culture device for quantitative analysis of human embryonic stem cells

(2008) Ken-ichiro Kamei et al.   LAB ON A CHIP

Biomolecular gradients in cell culture systems

(2007) Thomas M. Keenan et al.   LAB ON A CHIP