Review
Immunology
Prerana Muralidhara, Vanshika Sood, Vishnu Vinayak Ashok, Kushagra Bansal
Summary: Immunological tolerance is critical during pregnancy to protect the semi-allogeneic fetus from immune responses. Regulatory T cells (Tregs) accumulate at the placenta in the uterus during pregnancy and confer immunological tolerance at the maternal-fetal interface. Tregs play a role in supporting proper growth of the embryo during pregnancy and their dysfunction is associated with pregnancy-related complications. Tregs also have a similar role in tumor immunity by creating a tolerogenic system.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Yu-lei Gao, Ying Yao, Xiang Zhang, Fang Chen, Xiang-long Meng, Xin-sen Chen, Chao-lan Wang, Yan-cun Liu, Xin Tian, Song-tao Shou, Yan-fen Chai
Summary: This article introduces sepsis and its associated risks, high mortality rate, and long-term effects, as well as the research on regulatory T cells in sepsis over the past 20 years. Depending on different characteristics and contexts, Tregs may have both positive and negative effects. The article suggests that attenuating the symptoms and signs of sepsis can be achieved by regulating Tregs.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Paranita Ferronika, Safira Alya Dhiyani, Tri Budiarti, Irianiwati Widodo, Hanggoro Tri Rinonce, Sumadi Lukman Anwar
Summary: This study analyzed the infiltrative characteristics of TILs and Treg cells in BCC. The results showed that BCC is a cold tumor, with a high proportion of Treg cells and a low number of TILs. There was a positive correlation between Treg cells and TILs, and an inverse correlation between Treg cells and tumor invasion depth, indicating the anti-tumor capacity of Treg cells in BCC.
Review
Immunology
Chiel van Geffen, Astrid Deissler, Markus Quante, Harald Renz, Dominik Hartl, Saeed Kolahian
Summary: The immune system plays a crucial role in interstitial lung diseases, especially in the development and treatment response of pulmonary fibrosis. Understanding immune regulation is essential for the development of new therapeutic approaches for idiopathic pulmonary fibrosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Yuzhi Lu, Ni Xia, Xiang Cheng
Summary: Regulatory T cells (Tregs) play a crucial role in the development of chronic heart failure, suppressing excessive inflammatory responses and promoting stable scar formation in the early stage of heart injury. However, in chronic heart failure, the functions and phenotypes of Tregs change, transforming into a cell type that is harmful to the heart.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Paola de Candia, Claudio Procaccini, Claudia Russo, Maria Teresa Lepore, Giuseppe Matarese
Summary: Regulatory T cells, as key metabolic sensors, play a crucial role in controlling immune state and have promising therapeutic potential for autoimmune and metabolic disorders.
Review
Immunology
Fabian Flores-Borja, Paul Blair
Summary: This article discusses the induction of regulatory B cells in the tumour microenvironment and their role in suppressing anti-tumour responses. The article also explores the therapeutic implications of inhibiting Bregs in cancer. It highlights the importance of understanding the heterogeneity of Bregs and their interactions with other immune cells and the tumour itself in developing potential therapeutic tools to promote anti-tumour responses.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
McLane J. Watson, Paolo D. A. Vignali, Steven J. Mullett, Abigail E. Overacre-Delgoffe, Ronal M. Peralta, Stephanie Grebinoski, Ashley V. Menk, Natalie L. Rittenhouse, Kristin DePeaux, Ryan D. Whetstone, Dario A. A. Vignali, Timothy W. Hand, Amanda C. Poholek, Brett M. Morrison, Jeffrey D. Rothstein, Stacy G. Wendell, Greg M. Delgoffe
Summary: T-reg cells exhibit broad heterogeneity in glucose metabolism within normal and transformed tissues, utilizing an alternative metabolic pathway to maintain their suppressive function and proliferation. Glucose uptake is correlated with poorer suppressive function and long-term instability, while high-glucose conditions impair T-reg cell function and stability. Additionally, T-reg cells upregulate pathways involved in the metabolism of lactic acid, with lactate uptake being dispensable for peripheral T-reg cells but required intratumorally for slowed tumor growth and increased response to immunotherapy.
Review
Neurosciences
Huan Wang, Zhao Wang, Qianqian Wu, Yujia Yuan, Wen Cao, Xiangjian Zhang
Summary: Regulatory T cells (Tregs) play a crucial role in the inflammatory response and neuroplasticity process of ischemic stroke through various mechanisms. However, it remains unclear whether Tregs have a beneficial or deleterious effect in ischemic stroke and their specific roles in different stages are not well understood.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Cardiac & Cardiovascular Systems
Fabienne Burger, Kapka Miteva, Daniela Baptista, Aline Roth, Rodrigo A. Fraga-Silva, Catherine Martel, Nikolaos Stergiopulos, Francois Mach, Karim J. Brandt
Summary: The study shows that follicular regulatory helper T cells (T-FR) can control regulatory B cell (B-REG) populations in mice models on a high-cholesterol diet, leading to the suppression of proatherogenic processes. This suggests that T-FR cells may have atheroprotective effects by modulating immune processes related to atherosclerosis.
CARDIOVASCULAR RESEARCH
(2021)
Review
Oncology
Disha Rao, Fabienne Verburg, Kathrin Renner, Daniel S. Peeper, Ruben Lacroix, Christian U. Blank
Summary: Metabolic reprogramming in cancer cells leads to the formation of a tumour microenvironment characterized by nutrient restriction, hypoxia, acidity, and oxidative stress, unfavorable for effector T cells but conducive for immune-suppressive functions of Tregs. Tregs rely on oxidative phosphorylation for their functions and have metabolic adaptations in the tumour microenvironment. Targeting pathways responsible for Tregs' adaptation in the tumour microenvironment can improve anti-tumour immunity in preclinical models.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Kaschin Jamal Jameel, Willem-Jakob Gallert, Sarah D. Yanik, Susanne Panek, Juliane Kronsbein, David Jungck, Andrea Koch, Jurgen Knobloch
Summary: In smoking-induced COPD, patients with various comorbidities may have suppressed T-cell immunity, leading to a potential explanation for the association with frequent exacerbations. Different biomarkers at varying concentrations can modulate T-cell activation markers, with a clear shift towards suppressive effects, particularly for asthma- and cancer-related comorbidities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Natasa Kustrimovic, Daniela Gallo, Eliana Piantanida, Luigi Bartalena, Adriana Lai, Nicola Zerbinati, Maria Laura Tanda, Lorenzo Mortara
Summary: Maintaining the delicate balance between immune response and tolerance is crucial for health. T regulatory cells play a pivotal role in preserving self-tolerance and suppressing inflammation. In Graves' disease, these cells are likely impaired or reduced in frequency. Understanding the role of Tregs in Graves' disease is important for developing new treatment strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Nengqi Lin, Wei Yin, Heather Miller, Maria G. Byazrova, Andres A. Herrada, Kamel Benlagha, Pamela Lee, Fei Guan, Jiahui Lei, Quan Gong, Youqing Yan, Alexander Filatov, Chaohong Liu
Summary: Hepatitis B has become a major health threat worldwide, particularly in developing countries and regions. Infection with hepatitis B virus significantly increases the risk of liver diseases such as cirrhosis and cancer. The immune response against hepatitis B is mainly regulated by CD8+ T cells, which play a key role in fighting viral infections, while regulatory T cells prevent excessive immune response. Additionally, follicular T helper cells have a critical role in B-cell activation, proliferation, differentiation, and the formation of germinal centers. The development of hepatitis B virus is generally associated with immune system disorders or dysfunctions. This review focuses on the important functions and biological processes of regulatory T cells and follicular T helper cells during HBV infection.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Rami Alfar, John V. Napoleon, Imrul Shahriar, Richard Finnell, Cole Walchle, Austin Johnson, Philip S. Low
Summary: A specific ligand targeting folate receptor delta has been discovered to effectively target regulatory T cells and inhibit tumor growth, while manipulating the polarization of tumor-infiltrating immune cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Agata Raniszewska, Iwona Kwiecien, Rafal Sokolowski, Elzbieta Rutkowska, Joanna Domagala-Kulawik
Article
Oncology
A. Raniszewska, H. Vroman, D. Dumoulin, R. Cornelissen, J. G. J. Aerts, J. Domagala-Kulawik
Summary: The presence of PD-L1(+)CSCs is associated with altered T-cell frequency and phenotype, with higher percentages seen in patients with progressive disease. This suggests that CSCs can impact the immune system and may serve as a potential target for immunotherapy.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Review
Respiratory System
Joanna Domagala-Kulawik, Anna Trojnar
JOURNAL OF THORACIC DISEASE
(2020)
Article
Oncology
Iwona Kwiecien, Elzbieta Rutkowska, Malgorzata Polubiec-Kownacka, Agata Raniszewska, Piotr Rzepecki, Joanna Domagala-Kulawik
Summary: This study investigated the expression of PD-L2 and PD-L1 on AMs in BALF of lung cancer patients, finding that AMs in clBALF were positive for PD-L1 and PD-L2, and the proportion of PD-1+ T lymphocytes was higher in clBALF compared to hlBALF and PB. The study discussed the potential of exploring the PD-1-PD-L1/PD-L2 pathway in lung cancer environment.
TRANSLATIONAL LUNG CANCER RESEARCH
(2021)
Review
Oncology
Agata Raniszewska, Iwona Kwiecien, Elzbieta Rutkowska, Piotr Rzepecki, Joanna Domagala-Kulawik
Summary: Lung cancer poses a serious oncological issue worldwide, with cancer stem cells (CSCs) playing a crucial role in tumor initiation and metastasis. Age remains a significant risk factor for lung cancer development. The biology of this cancer continues to be an intriguing area of research, especially in terms of understanding the role of CSCs and age-related changes in carcinogenesis.
Editorial Material
Medicine, General & Internal
Joanna Domagala-Kulawik, Dragana Jovanovic, Chantal Raherison-Semjen
FRONTIERS IN MEDICINE
(2021)
Article
Cell Biology
Magdalena Dlugolecka, Jacek Szymanski, Lukasz Zareba, Zuzanna Homoncik, Joanna Domagala-Kulawik, Malgorzata Polubiec-Kownacka, Malgorzata Czystowska-Kuzmicz
Summary: The study conducted a comprehensive phenotyping of bronchopulmonary lavage fluid (BALF)-derived EVs from non-small cell lung cancer (NSCLC) patients using FL-NTA method, revealing that the method is suitable only for relatively pure EV isolates and may not be sensitive enough for more complex fluids like plasma. The research highlights the importance of sample composition and purity in FL-NTA analysis for the detection of EV-associated cancer biomarkers.
Review
Oncology
Iwona Kwiecien, Elzbieta Rutkowska, Agata Raniszewska, Piotr Rzepecki, Joanna Domagala-Kulawik
Summary: Different subpopulations of monocytes and dendritic cells play essential roles in modulating the immune response in malignancy, with potential pro-tumour and anti-tumour functions. Specific dendritic cell subsets are being explored for their beneficial effects in cancer immunotherapy.
WORLD JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mariusz Z. Ratajczak, Mateusz Adamiak, Andrzej Deptala, Joanna Domagala-Kulawik, Janina Ratajczak, Magdalena Kucia
Summary: This article discusses the induction of a sterile inflammation state through the activation of bone marrow stromal and innate immunity cells, which promotes the migration and engraftment of HSPCs. Deciphering these mechanisms will help in understanding the mechanisms of hematopoietic recovery after transplantation, and provide important information for optimizing the clinical process using small molecular modifiers of innate immunity and purinergic signaling.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Oncology
Iwona Kwiecien, Elzbieta Rutkowska, Agata Raniszewska, Rafal Sokolowski, Joanna Bednarek, Karina Jahnz-Rozyk, Piotr Rzepecki, Joanna Domagala-Kulawik
Summary: The study found that in patients with lung cancer, the percentage of dendritic cells (DCs) in metastatic lymph nodes and peripheral blood was higher, and the proportion of DCs expressing PD-1, PD-L1, and CD80 was also higher in metastatic lymph nodes. Additionally, a higher proportion of regulatory DCs (DCregs) was found in metastatic lymph nodes.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Review
Oncology
Izabela Orzolek, Jan Sobieraj, Joanna Domagala-Kulawik
Summary: This review presents the current understanding of sex hormones in the development of malignant diseases, with a focus on the role of estrogens in modifying the immune response to cancer. Sex hormones have diverse effects on the immune system and play a role in various physiological and pathological pathways.
Review
Oncology
Robert Ulinski, Iwona Kwiecien, Joanna Domagala-Kulawik
Summary: Chronic obstructive pulmonary disease (COPD) is an independent risk factor for lung cancer, and both diseases share similarities in immunopathogenesis. Some elements of autoimmunity may be involved in the development of emphysema and its relation with malignant transformation. COPD complicates lung cancer diagnosis and treatment, and tobacco smoking remains the main cause of these tobacco-dependent diseases.
Article
Psychiatry
Pawel Kwiecien, Joanna Domagala-Kulawik
Summary: Obesity is a leading preventable cause of death worldwide and is associated with various diseases. Risk factors for obesity vary, including genetic background, physical activity, sleep quality, diet, and sociological and environmental aspects. Psychological factors, especially personality traits, also play a significant role in the development and persistence of obesity.
PSYCHIATRIA I PSYCHOLOGIA KLINICZNA-JOURNAL OF PSYCHIATRY AND CLINICAL PSYCHOLOGY
(2023)
Review
Oncology
Anna Trojnar, Joanna Domagala-Kulawik
Summary: The issue of lung cancer among women is not often discussed in literature, with evidence of different histological distribution between sexes and an increasing prevalence of adenocarcinoma among women. Research on lung cancer risk factors can help in developing more effective screening programs.
ONCOLOGY IN CLINICAL PRACTICE
(2021)
Article
Oncology
Anna Trojnar, Joanna Domagala-Kulawik
Summary: The study analyzed data from 29 women with lung cancer and found that the majority were smokers, adenocarcinoma was the most common type, and extended menstrual cycles were the most common menstrual disorder.
ONCOLOGY IN CLINICAL PRACTICE
(2021)
