Article
Environmental Sciences
Sarah Rhodes, Elizabeth Christenson, Allie Nguyen, Jesper Larsen, Lance B. Price, Jill Stewart
Summary: The study found that industrial hog operations are more likely to carry multidrug-resistant Staphylococcus aureus compared to hogs raised without antibiotics. Conversely, antibiotic-free hogs are more likely to carry human-adapted S. aureus. This highlights the influence of antibiotic use practices on S. aureus populations in U.S. hogs and calls for increased monitoring for antibiotic resistance management.
ENVIRONMENTAL RESEARCH
(2021)
Editorial Material
Cell Biology
Neil P. Blackledge, Robert J. Klose
Summary: The Polycomb repressive system regulates gene expression and development through chromatin. The study by Cohen and colleagues in Genes & Development demonstrates that cooperation between PRC1 and PRC2 enables stable repression of non-epidermal transcription factors, preventing compromise of epidermal cell identity and disruption of normal skin development.
GENES & DEVELOPMENT
(2021)
Article
Chemistry, Multidisciplinary
Yi Wang, Yannan Zhao, Jiangling Wu, Ming Li, Juan Tan, Wensheng Fu, Hua Tang, Pu Zhang
Summary: The study engineered negatively charged sulfur quantum dots (SQDs) as an efficient broad-spectrum antibiotic to kill drug-resistant bacteria in vitro and in vivo. SQDs destroy bacterial membrane systems and affect their metabolism through the intrinsic antibacterial activity of elemental sulfur and catalytic generation of reactive oxygen species. Compared to traditional positively charged materials, SQDs demonstrate better hemocompatibility and lower toxicity.
Article
Infectious Diseases
Madisen A. Swallow, Ryan Fan, Jeffrey M. Cohen, Christopher G. Bunick
Summary: Almost 1 billion people worldwide have acne, and oral tetracyclines are commonly prescribed for treatment. However, concerns about antibiotic resistance and side effects have arisen. Sarecycline, a narrow-spectrum tetracycline approved in 2018, shows promise in reducing resistance risk by targeting the pathogenic bacterium in acne vulgaris.
Article
Infectious Diseases
Kirill V. Ovchinnikov, Christian Kranjec, Tage Thorstensen, Harald Carlsen, Dzung B. Diep
Summary: The rise of antibiotic-resistant bacteria is a major challenge in human and veterinary medicine. This study highlights the importance of searching for antimicrobials for veterinary applications to prevent the misuse of frontline clinical antibiotics. The research shows that a combination of bacteriocins, namely micrococcin P1 and EntEJ97s, with conventional antibiotic penicillin G can synergistically combat methicillin-resistant Staphylococcus pseudintermedius (MRSP), a common pathogen in animal skin infections, and prevent the development of resistance. It also demonstrates the therapeutic potential of this combination in a murine skin infection model.
Review
Microbiology
Pedro Sanchez-Pellicer, Laura Navarro-Moratalla, Eva Nunez-Delegido, Beatriz Ruzafa-Costas, Juan Aguera-Santos, Vicente Navarro-Lopez
Summary: This narrative review examines the influence of human microbiota on the pathogenesis of acne and the impact of probiotics treatment as an adjuvant or alternative therapy on the progression of acne vulgaris. Acne is a chronic inflammatory skin disease involving various factors such as genetics, metabolism, and hormones, with both skin and gut microbiota playing a role. Bidirectional communication between intestinal microbiota and skin homeostasis has been observed, mainly through immune system modification. Probiotics have shown potential beneficial effects in in vitro studies, but clinical trials with topical and oral probiotics are scarce.
Review
Biochemistry & Molecular Biology
Giorgia Condro, Marta Guerini, Michela Castello, Paola Perugini
Summary: The skin microbiota plays an important role in maintaining healthy skin, but its balance can be disrupted by various factors, leading to the development of skin diseases. The correlation between diseases like acne vulgaris, atopic dermatitis, rosacea and the skin microbiota is still unclear, and more research is needed to explore the specific subspecies and strains involved.
Article
Dermatology
Katherine G. Thompson, Barbara M. Rainer, Corina Antonescu, Liliana Florea, Emmanuel F. Mongodin, Sewon Kang, Anna L. Chien
Summary: The study revealed significant differences in the skin microbiota of patients with rosacea and acne, with rosacea patients showing higher abundance of C acnes and Serratia marcescens compared to acne patients. This suggests potential clues towards understanding the distinct disease progression of each condition.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Microbiology
Zitao Guo, Yuliang Yang, Qianjie Wu, Meng Liu, Leyuan Zhou, Liang Zhang, Dake Dong
Summary: This study investigated the skin microbiota of Asian acne patients using 16S and 18S rRNA gene sequencing. The results showed that the species diversity of the skin microbiota did not differ significantly between groups. However, there were significant alterations in the abundance of certain bacteria and fungi in severe acne patients, particularly a decrease in Pseudomonas and Ralstonia and an increase in Pseudidiomarina and Candida. Additionally, different acne sites had different biomarkers, with the cheek having the highest number of biomarkers.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Veterinary Sciences
Mariana Grecu, Madalina-Elena Henea, Cristina Mihaela Rimbu, Catalina Simion, Eusebiu-Viorel Sindilar, Gheorghe Solcan
Summary: Pseudomonas aeruginosa is a highly pathogenic bacterium that can cause serious infections, especially in dogs. Treatment of infections caused by this bacterium is challenging due to antimicrobial resistance. Bacteriophage therapy has shown potential in alleviating bacterially complicated skin lesions that do not respond to antimicrobial therapy.
VETERINARY SCIENCES
(2023)
Article
Pediatrics
Tao Yang, Jiangyi Wang, Junya Cao, Xinyue Zhang, Yun Lai, Longnian Li, Xiaoying Ye, Cong You
Summary: Older ages and external application of fusidic acid were associated with shorter treatment course, while elevated leukocytes and CRP level indicated prolonged intravenous antibiotic treatment course. The positive culture rates of periorificial and throat swabs were higher compared to blood samples. Resistance to oxacillin and vancomycin was rare, while resistance to clindamycin was common. Clindamycin monotherapy for SSSS should be avoided.
ITALIAN JOURNAL OF PEDIATRICS
(2021)
Article
Dermatology
Lang Sun, Qingqun Wang, Huan Wang, Jing Huang, Zheng Yu
Summary: This study found that the skin microbiota of acne patients is closely related to the duration of the disease. Cutibacterium dominated the skin surface in the first three years of acne, but was gradually replaced by Staphylococcus. Lactobacillus and Acinetobacter were more abundant on normal skin and decreased with increasing disease duration on the skin surface. Moreover, there was a significant increase in microbial interactions in both the skin surface and pores in the 4-6 years group.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Biology
Karolina Chilicka, Iwona Dziendziora-Urbinska, Renata Szygula, Binnaz Asanova, Danuta Nowicka
Summary: Acne vulgaris is a chronic disease that affects quality of life and social interactions, and is related to the formation of skin lesions, intestinal microbiota, and the use of probiotics.
Article
Biotechnology & Applied Microbiology
Camila Folle, Ana M. Marques, Natalia Diaz-Garrido, Marta Espina, Elena Sanchez-Lopez, Josefa Badia, Laura Baldoma, Ana Cristina Calpena, Maria Luisa Garcia
Summary: Thymol nanoparticles (TH-NPs) with suitable particle size, surface charge, and high encapsulation efficiency demonstrated sustained release of thymol, potent antimicrobial activity against Cutibacterium acnes, and minor effect towards Staphylococcus epidermis. TH-NPs showed promise as an alternative treatment for skin acne infection, avoiding antibiotic administration and preventing microbial drug resistance, while maintaining stability and sterility during storage. Additionally, TH-NPs enhanced thymol's antioxidant activity, offering a natural, preservative-free approach for acne treatment.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Vartika, Monika Chaudhary, Sameer Suresh Bhagyawant, Nidhi Srivastava
Summary: The study investigated the antibacterial activity of saponins (bio-surfactants) characterized using mass spectroscopy against acne-causing bacteria. Saponins induced the release of cellular components and caused cellular and membrane disturbances. Morphological changes on the bacterial cell surface structure revealed disruption of cell integrity leading to death, confirming the potential applications of saponins in pharmaceutical preparations.
CELL BIOCHEMISTRY AND BIOPHYSICS
(2022)
Article
Biochemistry & Molecular Biology
Prakash Kumar Shulda, Lovely Gautam, Mau Sinha, Punit Kaur, Sujata Sharma, Tej P. Singh
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
(2015)
Article
Dermatology
Suresh Sadhasivam, Mau Sinha, Swamini Saini, Simar Preet Kaur, Tanvi Gupta, Shiladitya Sengupta, Shamik Ghosh, Kabir Sardana
DERMATOLOGIC THERAPY
(2016)
Article
Dermatology
Sumana Ghosh, Mau Sinha, Anamika Bhattacharyya, Suresh Sadhasivam, Jayasundarnaidu Megha, Sreedhar Reddy, Swamini Saini, Himanshi Singh, Deepak Kumar, Simar Preet Kaur, Mallika Mishra, Dandamudi Usharani, Shamik Ghosh, Shiladitya Sengupta
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Avinash Singh, Ashok Kumar, Lovely Gautam, Pradeep Sharma, Mau Sinha, Asha Bhushan, Punit Kaur, Sujata Sharma, Ashish Arora, Tej P. Singh
BIOCHEMICAL JOURNAL
(2014)
Review
Biochemistry & Molecular Biology
Sujata Sharma, Sanket Kaushik, Mau Sinha, Gajraj Singh Kushwaha, Avinash Singh, Juhi Sikarwar, Anshul Chaudhary, Akshita Gupta, Punit Kaur, Tej P. Singh
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
(2014)
Article
Biochemistry & Molecular Biology
Nilisha Rastogi, Avinash Singh, Sada Nand Pandey, Mau Sinha, Asha Bhushan, Punit Kaur, Sujata Sharma, Tej P. Singh
Review
Cell Biology
Mau Sinha, Lovely Gautam, Prakash Kumar Shukla, Punit Kaur, Sujata Sharma, Tej P. Singh
MEDIATORS OF INFLAMMATION
(2013)
Article
Multidisciplinary Sciences
Pradeep Sharma, Divya Dube, Mau Sinha, Savita Yadav, Punit Kaur, Sujata Sharma, Tej P. Singh
Article
Multidisciplinary Sciences
Sanket Kaushik, Nagendra Singh, Shavait Yamini, Avinash Singh, Mau Sinha, Ashish Arora, Punit Kaur, Sujata Sharma, Tej P. Singh
Article
Multidisciplinary Sciences
Nilisha Rastogi, Nitish Nagpal, Hammad Alam, Sadanand Pandey, Lovely Gautam, Mau Sinha, Kouichirou Shin, Nikhat Manzoor, Jugsharan S. Virdi, Punit Kaur, Sujata Sharma, Tej P. Singh
Article
Biochemistry & Molecular Biology
Gajraj Singh Kushwaha, Shavait Yamini, Mukesh Kumar, Mau Sinha, Punit Kaur, Sujata Sharma, Tej P. Singh
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
(2013)
Review
Multidisciplinary Sciences
Mau Sinha, Rashmi Prabha Singh, Gajraj Singh Kushwaha, Naseer Iqbal, Avinash Singh, Sanket Kaushik, Punit Kaur, Sujata Sharma, Tej P. Singh
SCIENTIFIC WORLD JOURNAL
(2014)
Article
Biochemistry & Molecular Biology
Avinash Singh, Lovely Gautam, Mau Sinha, Asha Bhushan, Punit Kaur, Sujata Sharma, T. P. Singh
Article
Pharmacology & Pharmacy
Rohit Batra, Suresh Sadhasivam, Swamini Saini, Swati Gupta, Rahul Kumar Singh Bisen, Mau Sinha, Shamik Ghosh, Shilpi Jain
