Acne, Microbiome, and Probiotics: The Gut–Skin Axis

Predominant Role of mTOR Signaling in Skin Diseases with Therapeutic Potential

(2022) Fani Karagianni et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Genome-wide association meta-analysis identifies 29 new acne susceptibility loci

(2022) Brittany L. Mitchell et al.   Nature Communications

Facial Acne: A Randomized, Double-Blind, Placebo-Controlled Study on the Clinical Efficacy of a Symbiotic Dietary Supplement

(2022) Fabio Rinaldi et al.   Dermatology and Therapy

Characterization of a Cutibacterium acnes Camp Factor 1-Related Peptide as a New TLR-2 Modulator in In Vitro and Ex Vivo Models of Inflammation

(2022) Constance Mayslich et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Efficacy of probiotic‐derived lotion from Lactobacillus paracasei MSMC 39‐1 in mild to moderate acne vulgaris, randomized controlled trial

(2022) Sunattha Sathikulpakdee et al.   Journal of Cosmetic Dermatology

Topical Probiotics: More Than a Skin Deep

(2022) Mohammed Habeebuddin et al.   Pharmaceutics

Diet and acne: review of the evidence from 2009 to 2020

(2021) Federica Dall’Oglio et al.   INTERNATIONAL JOURNAL OF DERMATOLOGY

Sex hormones and acne: State of the art

(2021) Tingting Hu et al.   JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT

Gut–Skin Axis: Current Knowledge of the Interrelationship between Microbial Dysbiosis and Skin Conditions

(2021) Britta De Pessemier et al.   Microorganisms

Cutibacterium acnes as an Opportunistic Pathogen: An Update of Its Virulence-Associated Factors

(2021) Constance Mayslich et al.   Microorganisms

Control of Immunity by the Microbiota

(2021) Eduard Ansaldo et al.   Annual Review of Immunology

Postmenopausal hyperandrogenism

(2021) T. Yoldemir   CLIMACTERIC

The Skin Microbiome and the Gut-Skin Axis

(2021) Shivani Sinha et al.   CLINICS IN DERMATOLOGY

Characterization of Weissella viridescens UCO-SMC3 as a Potential Probiotic for the Skin: Its Beneficial Role in the Pathogenesis of Acne Vulgaris

(2021) Marcela Espinoza-Monje et al.   Microorganisms

Probiotics in the Therapeutic Arsenal of Dermatologists

(2021) Vicente Navarro-López et al.   Microorganisms

The Gut–Brain Axis

(2021) Emeran A. Mayer et al.   Annual Review of Medicine

Comparative Genomic Analyses and CRISPR-Cas Characterization of Cutibacterium acnes Provide Insights Into Genetic Diversity and Typing Applications

(2021) Natalia Cobian et al.   Frontiers in Microbiology

A study comparing the clinical and hormonal profile of late onset and persistent acne in adult females

(2020) Kabir Sardana et al.   INTERNATIONAL JOURNAL OF DERMATOLOGY

Omega-3 Versus Omega-6 Polyunsaturated Fatty Acids in the Prevention and Treatment of Inflammatory Skin Diseases

(2020) Anamaria Balić et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Impact of lifestyle and demographics on the gut microbiota of acne patients and the response to minocycline

(2020) B. M. Rainer et al.   JOURNAL OF DERMATOLOGICAL TREATMENT

Porphyrin Production and Regulation in Cutaneous Propionibacteria

(2020) Emma Barnard et al.   mSphere

Systematic review of the epidemiology of acne vulgaris

(2020) Anna Hwee Sing Heng et al.   Scientific Reports

An updated review of the sebaceous gland and its role in health and diseases Part 1: Embryology, evolution, structure, and function of sebaceous glands

(2020) Gelan Shamloul et al.   Dermatologic Therapy

Adaptation of acneic and non acneic strains of Cutibacterium acnes to sebum‐like environment

(2019) Valérie Borrel et al.   MicrobiologyOpen

The gut-liver axis in liver disease: pathophysiological basis for therapy

(2019) Agustín Albillos et al.   JOURNAL OF HEPATOLOGY

Developing an in vitro artificial sebum model to study Propionibacterium acnes biofilms

(2018) Karl-Jan Spittaels et al.   ANAEROBE

New Approach in Acne Therapy

(2018) Francesca Deidda et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Cutibacterium acnes (Propionibacterium acnes ) and acne vulgaris: a brief look at the latest updates

(2018) B. Dréno et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Gut microbiota and mTOR signaling: Insight on a new pathophysiological interaction

(2018) Mohamed H. Noureldein et al.   MICROBIAL PATHOGENESIS

The human skin microbiome

(2018) Allyson L. Byrd et al.   NATURE REVIEWS MICROBIOLOGY

The Gut Microbiome as a Major Regulator of the Gut-Skin Axis

(2018) Iman Salem et al.   Frontiers in Microbiology

Patients with Acne Vulgaris Have a Distinct Gut Microbiota in Comparison with Healthy Controls

(2018) Y Deng et al.   ACTA DERMATO-VENEREOLOGICA

Gut microbiota alterations in moderate to severe acne vulgaris patients

(2018) Hui-Min Yan et al.   JOURNAL OF DERMATOLOGY

You are what you eat: diet, health and the gut microbiota

(2018) Niv Zmora et al.   Nature Reviews Gastroenterology & Hepatology

Androgens in Women: Androgen mediated skin disease and patient evaluation (Part I)

(2018) Amanda Bienenfeld et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Novel combination for the treatment of acne differentiated based on gender: a new step towards personalized treatment

(2018) Ersilia Tolino et al.   GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA

Association of Psoriasis With Inflammatory Bowel Disease

(2018) Yun Fu et al.   JAMA Dermatology

The Short-Chain Fatty Acid Sodium Butyrate Functions as a Regulator of the Skin Immune System

(2017) Agatha Schwarz et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

What is new in the pathophysiology of acne, an overview

(2017) B. Dréno   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Propionibacterium acnes phylotypes and acne severity: an observational prospective study

(2017) C. Paugam et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Heritability and GWAS Analyses of Acne in Australian Adolescent Twins

(2017) Angela Mina-Vargas et al.   Twin Research and Human Genetics

Transcriptomic analysis of Propionibacterium acnes biofilms in vitro

(2016) Anika C. Jahns et al.   ANAEROBE

The gut-skin axis in health and disease: A paradigm with therapeutic implications

(2016) Catherine A. O'Neill et al.   BIOESSAYS

Skin expression of mammalian target of rapamycin and forkhead box transcription factor O1, and serum insulin-like growth factor-1 in patients with acne vulgaris and their relationship with diet

(2016) N.F. Agamia et al.   BRITISH JOURNAL OF DERMATOLOGY

Topical application of probiotics in skin: adhesion, antimicrobial and antibiofilmin vitroassays

(2016) E.G. Lopes et al.   JOURNAL OF APPLIED MICROBIOLOGY

Different Propionibacterium acnes Phylotypes Induce Distinct Immune Responses and Express Unique Surface and Secreted Proteomes

(2016) Yang Yu et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Dietary glycemic factors, insulin resistance, and adiponectin levels in acne vulgaris

(2016) Aslı Aksu Çerman et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Emerging pathogenic links between microbiota and the gut–lung axis

(2016) Kurtis F. Budden et al.   NATURE REVIEWS MICROBIOLOGY

Intestinal-borne dermatoses significantly improved by oral application ofEscherichia coliNissle 1917

(2016) Elina Manzhalii et al.   WORLD JOURNAL OF GASTROENTEROLOGY

mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation

(2016) Xiaolei Ding et al.   Nature Communications

Supplementation with Lactobacillus rhamnosus SP1 normalises skin expression of genes implicated in insulin signalling and improves adult acne

(2016) G. Fabbrocini et al.   Beneficial Microbes

Strain-Level Differences in Porphyrin Production and Regulation in Propionibacterium acnes Elucidate Disease Associations

(2016) Tremylla Johnson et al.   mSphere

TLR-2 Recognizes Propionibacterium acnes CAMP Factor 1 from Highly Inflammatory Strains

(2016) Coralie Lheure et al.   PLoS One

Chronic Repression of mTOR Complex 2 Induces Changes in the Gut Microbiota of Diet-induced Obese Mice

(2016) Mi-Ja Jung et al.   Scientific Reports

The balance of metagenomic elements shapes the skin microbiome in acne and health

(2016) Emma Barnard et al.   Scientific Reports

What's new in the physiopathology of acne?

(2015) D.H. Suh et al.   BRITISH JOURNAL OF DERMATOLOGY

Mechanistic target of rapamycin (mTOR) expression is increased in acne patients' skin

(2015) Giuseppe Monfrecola et al.   EXPERIMENTAL DERMATOLOGY

Understanding innate immunity and inflammation in acne: implications for management

(2015) B. Dreno et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Identification of Bacterial DNA in the Peripheral Blood of Patients With Active Psoriasis

(2015) Ana Ramírez-Boscá et al.   JAMA Dermatology

Acne vulgaris

(2015) Sara Moradi Tuchayi et al.   Nature Reviews Disease Primers

Prospective, Randomized, Open-Label Trial Comparing the Safety, Efficacy, and Tolerability of an Acne Treatment Regimen with and without a Probiotic Supplement and Minocycline in Subjects with Mild to Moderate Acne

(2015) Gordon W. Jung et al.   JOURNAL OF CUTANEOUS MEDICINE AND SURGERY

Free fatty acids as modulators of the NLRP3 inflammasome in obesity/type 2 diabetes

(2014) Sylvie Legrand-Poels et al.   BIOCHEMICAL PHARMACOLOGY

Acne, quorum sensing and danger

(2014) S. M. Lwin et al.   CLINICAL AND EXPERIMENTAL DERMATOLOGY

Biogeography and individuality shape function in the human skin metagenome

(2014) Julia Oh et al.   NATURE

Proteome Analysis of Human Sebaceous Follicle Infundibula Extracted from Healthy and Acne-Affected Skin

(2014) Malene Bek-Thomsen et al.   PLoS One

Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris

(2014) Alexander A. Navarini et al.   Nature Communications

Two new susceptibility loci 1q24.2 and 11p11.2 confer risk to severe acne

(2014) Li He et al.   Nature Communications

Staphylococcus epidermidis in the human skin microbiome mediates fermentation to inhibit the growth of Propionibacterium acnes: implications of probiotics in acne vulgaris

(2013) Yanhan Wang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Analysis of distribution patterns ofPropionibacterium acnesphylotypes andPeptostreptococcusspecies from acne lesions

(2013) H.H. Kwon et al.   BRITISH JOURNAL OF DERMATOLOGY

Inflammasome-Mediated Secretion of IL-1  in Human Monocytes through TLR2 Activation; Modulation by Dietary Fatty Acids

(2013) R. G. Snodgrass et al.   JOURNAL OF IMMUNOLOGY

Propionibacterium acnes Strain Populations in the Human Skin Microbiome Associated with Acne

(2013) Sorel Fitz-Gibbon et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

IL-1β Drives Inflammatory Responses to Propionibacterium acnes In Vitro and In Vivo

(2013) Magdalena Kistowska et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Steroidogenesis in the skin: Implications for local immune functions

(2013) Andrzej Slominski et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Amino acid signalling upstream of mTOR

(2013) Jenna L. Jewell et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Opportunistic Pathogen Propionibacterium acnes: Insights into Typing, Human Disease, Clonal Diversification and CAMP Factor Evolution

(2013) Andrew McDowell et al.   PLoS One

Innate immune defense system of the skin

(2013) Maryam Afshar et al.   VETERINARY DERMATOLOGY

Pan-Genome and Comparative Genome Analyses of Propionibacterium acnes Reveal Its Genomic Diversity in the Healthy and Diseased Human Skin Microbiome

(2013) S. Tomida et al.   mBio

Bacterial skin commensals and their role as host guardians

(2013) G.J.M. Christensen et al.   Beneficial Microbes

In Vitro evaluation of antibacterial activities and anti-inflammatory effects of Bifidobacterium spp. addressing acne vulgaris

(2012) Do-Kyung Lee et al.   ARCHIVES OF PHARMACAL RESEARCH

An increased incidence of Propionibacterium acnes biofilms in acne vulgaris: a case-control study

(2012) A.C. Jahns et al.   BRITISH JOURNAL OF DERMATOLOGY

Epidemiology of acne vulgaris

(2012) K. Bhate et al.   BRITISH JOURNAL OF DERMATOLOGY

Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010

(2012) Theo Vos et al.   LANCET

An Expanded Multilocus Sequence Typing Scheme for Propionibacterium acnes: Investigation of ‘Pathogenic’, ‘Commensal’ and Antibiotic Resistant Strains

(2012) Andrew McDowell et al.   PLoS One

Acne: prevalence and relationship with dietary habits in Eskisehir, Turkey

(2011) A.E. Koku Aksu et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Toll-like receptors and skin

(2011) A.T. Ermertcan et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Effect of insulin-like growth factor-1 deficiency or administration on the occurrence of acne

(2010) D. Ben-Amitai et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Lipid Mediators in Acne

(2010) Monica Ottaviani et al.   MEDIATORS OF INFLAMMATION

Dietary effect of lactoferrin-enriched fermented milk on skin surface lipid and clinical improvement of acne vulgaris

(2010) Jungmin Kim et al.   NUTRITION

Population Genetic Analysis of Propionibacterium acnes Identifies a Subpopulation and Epidemic Clones Associated with Acne

(2010) Hans B. Lomholt et al.   PLoS One

Biofilm formation by Propionibacterium acnes is a characteristic of invasive isolates

(2009) A. Holmberg et al.   CLINICAL MICROBIOLOGY AND INFECTION

Sebum Free Fatty Acids Enhance the Innate Immune Defense of Human Sebocytes by Upregulating β-Defensin-2 Expression

(2009) Teruaki Nakatsuji et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Antimicrobial activity of enterocins from Enterococcus faecalis SL-5 against Propionibacterium acnes, the causative agent in acne vulgaris, and its therapeutic effect

(2009) Bong Seon Kang et al.   JOURNAL OF MICROBIOLOGY

Mechanism of androgen receptor action

(2009) Jin Li et al.   MATURITAS

Effect of konjac glucomannan hydrolysates and probiotics on the growth of the skin bacteriumPropionibacterium acnes in vitro

(2009) F. H. Al-Ghazzewi et al.   INTERNATIONAL JOURNAL OF COSMETIC SCIENCE

The sebocyte culture: a model to study the pathophysiology of the sebaceous gland in sebostasis, seborrhoea and acne

(2008) Christos C. Zouboulis et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

The Commensal Streptococcus salivarius K12 Downregulates the Innate Immune Responses of Human Epithelial Cells and Promotes Host-Microbe Homeostasis

(2008) C. Cosseau et al.   INFECTION AND IMMUNITY

A new phylogenetic group of Propionibacterium acnes

(2008) A. McDowell et al.   JOURNAL OF MEDICAL MICROBIOLOGY

IGF-1 Induces SREBP-1 Expression and Lipogenesis in SEB-1 Sebocytes via Activation of the Phosphoinositide 3-Kinase/Akt Pathway

(2007) Terry M. Smith et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY