Sonic hedgehog signaling in kidney fibrosis: a master communicator

Hepatic expression of Sonic Hedgehog induces liver fibrosis and promotes hepatocarcinogenesis in a transgenic mouse model

(2016) Sook In Chung et al.   JOURNAL OF HEPATOLOGY

Reemergence of Hedgehog Mediates Epithelial–Mesenchymal Crosstalk in Pulmonary Fibrosis

(2015) Biao Hu et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Perivascular Gli1+ Progenitors Are Key Contributors to Injury-Induced Organ Fibrosis

(2015) Rafael Kramann et al.   Cell Stem Cell

Ptch2 shares overlapping functions with Ptch1 in Smo regulation and limb development

(2015) Olena Zhulyn et al.   DEVELOPMENTAL BIOLOGY

Pharmacological GLI2 inhibition prevents myofibroblast cell-cycle progression and reduces kidney fibrosis

(2015) Rafael Kramann et al.   JOURNAL OF CLINICAL INVESTIGATION

Wnt/β-catenin signaling in kidney injury and repair: a double-edged sword

(2015) Dong Zhou et al.   LABORATORY INVESTIGATION

Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease

(2015) M Teresa Grande et al.   NATURE MEDICINE

Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis

(2015) Sara Lovisa et al.   NATURE MEDICINE

Wnt/β-catenin signalling and podocyte dysfunction in proteinuric kidney disease

(2015) Lili Zhou et al.   Nature Reviews Nephrology

Understanding the mechanisms of kidney fibrosis

(2015) Dong Zhou et al.   Nature Reviews Nephrology

Targeting the Hedgehog signaling pathway in cancer: beyond Smoothened

(2015) Annelies Gonnissen et al.   Oncotarget

Ptch2 mediates the Shh response in Ptch1-/- cells

(2014) A. C. Alfaro et al.   DEVELOPMENT

Maternal diabetes modulates kidney formation in murine progeny: the role of hedgehog interacting protein (HHIP)

(2014) Xin-Ping Zhao et al.   DIABETOLOGIA

Ballooned hepatocytes, undead cells, sonic hedgehog, and Vitamin E: Therapeutic implications for nonalcoholic steatohepatitis

(2014) Petra Hirsova et al.   HEPATOLOGY

Cellular and molecular mechanisms in kidney fibrosis

(2014) Jeremy S. Duffield   JOURNAL OF CLINICAL INVESTIGATION

Sonic Hedgehog Is a Novel Tubule-Derived Growth Factor for Interstitial Fibroblasts after Kidney Injury

(2014) D. Zhou et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Multiple Genes of the Renin-Angiotensin System Are Novel Targets of Wnt/ -Catenin Signaling

(2014) L. Zhou et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development

(2014) Hyun Mi Kang et al.   NATURE MEDICINE

Canonical and non-canonical Hedgehog signalling and the control of metabolism

(2014) Raffaele Teperino et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Kick it up a notch: Notch signaling and kidney fibrosis

(2014) Mariya T. Sweetwyne et al.   Kidney International Supplements

Wnt/β-catenin signaling and kidney fibrosis

(2014) Roderick J. Tan et al.   Kidney International Supplements

Platelet-derived growth factor-A and sonic hedgehog signaling direct lung fibroblast precursors during alveolar septal formation

(2013) Stephen E. McGowan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The Hedgehog System Machinery Controls Transforming Growth Factor-β–Dependent Myofibroblastic Differentiation in Humans

(2012) Natacha Cigna et al.   AMERICAN JOURNAL OF PATHOLOGY

Hedgehog-Gli Pathway Activation during Kidney Fibrosis

(2012) Steven L. Fabian et al.   AMERICAN JOURNAL OF PATHOLOGY

Role of Sonic Hedgehog in idiopathic pulmonary fibrosis

(2012) Alfredo Lozano Bolaños et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Hedgehog signaling controls fibroblast activation and tissue fibrosis in systemic sclerosis

(2012) Angelika Horn et al.   ARTHRITIS AND RHEUMATISM

Renin^|^ndash;Angiotensin System, Hypertension, and Chronic Kidney Disease: Pharmacogenetic Implications

(2012) Paulo Caleb Junior Lima Santos et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Sonic Hedgehog Signaling Mediates Epithelial-Mesenchymal Communication and Promotes Renal Fibrosis

(2012) H. Ding et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Tubular cell dedifferentiation and peritubular inflammation are coupled by the transcription regulator Id1 in renal fibrogenesis

(2012) Yingjian Li et al.   KIDNEY INTERNATIONAL

Tubule-specific ablation of endogenous β-catenin aggravates acute kidney injury in mice

(2012) Dong Zhou et al.   KIDNEY INTERNATIONAL

Prevalence of chronic kidney disease in China: a cross-sectional survey

(2012) Luxia Zhang et al.   LANCET

The Hedgehog Signal Transduction Network

(2012) D. J. Robbins et al.   Science Signaling

Hedgehog Signaling

(2012) P. W. Ingham   Cold Spring Harbor Perspectives in Biology

Desert hedgehog is a mammal-specific gene expressed during testicular and ovarian development in a marsupial

(2011) William A O'Hara et al.   BMC DEVELOPMENTAL BIOLOGY

Increased production of sonic hedgehog by ballooned hepatocytes

(2011) Fatima Rangwala et al.   JOURNAL OF PATHOLOGY

Canonical Wnt/β-catenin signaling mediates transforming growth factor-β1-driven podocyte injury and proteinuria

(2011) Dan Wang et al.   KIDNEY INTERNATIONAL

Cellular and molecular mechanisms of renal fibrosis

(2011) Youhua Liu   Nature Reviews Nephrology

A Novel Signaling Pathway Mediated by the Nuclear Targeting of C-Terminal Fragments of Mammalian Patched 1

(2011) Hiroki Kagawa et al.   PLoS One

A Novel Synthetic Smoothened Antagonist Transiently Inhibits Pancreatic Adenocarcinoma Xenografts in a Mouse Model

(2011) Martin F. Strand et al.   PLoS One

Sonic Hedgehog Activates the GTPases Rac1 and RhoA in a Gli-Independent Manner Through Coupling of Smoothened to Gi Proteins

(2011) A. H. Polizio et al.   Science Signaling

Hedgehog proteins activate pro-angiogenic responses in endothelial cells through non-canonical signaling pathways

(2010) Pilar Chinchilla et al.   CELL CYCLE

Intracellular Calcium Release and Protein Kinase C Activation Stimulate Sonic Hedgehog Gene Expression During Gastric Acid Secretion

(2010) Mohamad El–Zaatari et al.   GASTROENTEROLOGY

A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu–Gli protein complexes

(2010) Hanna Tukachinsky et al.   JOURNAL OF CELL BIOLOGY

Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans

(2010) Bernhard Bielesz et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanisms of Tubulointerstitial Fibrosis

(2010) M. Zeisberg et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Epidemiology of CKD in Europe: an uncertain scenario

(2010) C. Zoccali et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

GDC-0449—A potent inhibitor of the hedgehog pathway

(2009) Kirk D. Robarge et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Hedgehog signalling: Emerging evidence for non-canonical pathways

(2009) Dagan Jenkins   CELLULAR SIGNALLING

Hedgehog Target Genes: Mechanisms of Carcinogenesis Induced by Aberrant Hedgehog Signaling Activation

(2009) Y. Katoh et al.   CURRENT MOLECULAR MEDICINE

Wnt/ -Catenin Signaling Promotes Renal Interstitial Fibrosis

(2009) W. He et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

New Insights into Epithelial-Mesenchymal Transition in Kidney Fibrosis

(2009) Y. Liu   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia

(2009) Chen Zhao et al.   NATURE

Sonic Hedgehog Guides Axons through a Noncanonical, Src-Family-Kinase-Dependent Signaling Pathway

(2009) Patricia T. Yam et al.   NEURON

Dose- and Route-Dependent Teratogenicity, Toxicity, and Pharmacokinetic Profiles of the Hedgehog Signaling Antagonist Cyclopamine in the Mouse

(2008) Robert J. Lipinski et al.   TOXICOLOGICAL SCIENCES

Sonic hedgehog is an autocrine viability factor for myofibroblastic hepatic stellate cells

(2007) Liu Yang et al.   JOURNAL OF HEPATOLOGY