How to make insulin-producing pancreatic β cells for diabetes treatment

Timeline: iPSCs—The First Decade

(2016) Sheila Chari et al.   Cell Stem Cell

Reprogrammed Stomach Tissue as a Renewable Source of Functional β Cells for Blood Glucose Regulation

(2016) Chaiyaboot Ariyachet et al.   Cell Stem Cell

A combination of cytokines EGF and CNTF protects the functional beta cell mass in mice with short-term hyperglycaemia

(2016) Marie Lemper et al.   DIABETOLOGIA

Activin Enhances α- to β-Cell Transdifferentiation as a Source For β-Cells In Male FSTL3 Knockout Mice

(2016) Melissa L. Brown et al.   ENDOCRINOLOGY

Long-term glycemic control using polymer-encapsulated human stem cell–derived beta cells in immune-competent mice

(2016) Arturo J Vegas et al.   NATURE MEDICINE

A decade of transcription factor-mediated reprogramming to pluripotency

(2016) Kazutoshi Takahashi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Human pancreatic beta-like cells converted from fibroblasts

(2016) Saiyong Zhu et al.   Nature Communications

Regenerative Therapy of Type 1 Diabetes Mellitus: From Pancreatic Islet Transplantation to Mesenchymal Stem Cells

(2016) Nadine E. Rekittke et al.   Stem Cells International

A High-content In Vitro Pancreatic Islet β-cell Replication Discovery Platform

(2016) Zhengshan Zhao et al.   Jove-Journal of Visualized Experiments

Circulating IGF-I and IGFBP3 Levels Control Human Colonic Stem Cell Function and Are Disrupted in Diabetic Enteropathy

(2015) Francesca D’Addio et al.   Cell Stem Cell

Pax4 Expression does not Transduce Pancreatic Alpha Cells to Beta Cells

(2015) Ling Chen et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Islet formation in mice and men: lessons for the generation of functional insulin-producing β-cells from human pluripotent stem cells

(2015) Gopika Nair et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

BMP-7 Induces Adult Human Pancreatic Exocrine-to-Endocrine Conversion

(2015) Dagmar Klein et al.   DIABETES

Hyperglycaemia attenuates in vivo reprogramming of pancreatic exocrine cells to beta cells in mice

(2015) Claudia Cavelti-Weder et al.   DIABETOLOGIA

Controlled induction of human pancreatic progenitors produces functional beta-like cells in vitro

(2015) H. A. Russ et al.   EMBO JOURNAL

Current Status on Stem Cells and Cancers of the Gastric Epithelium

(2015) Werner Hoffmann   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

In vitro reprogramming of pancreatic alpha cells towards a beta cell phenotype following ectopic HNF4α expression

(2015) Caroline B. Sangan et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Sequential cancer mutations in cultured human intestinal stem cells

(2015) Jarno Drost et al.   NATURE

A prevascularized subcutaneous device-less site for islet and cellular transplantation

(2015) Andrew R Pepper et al.   NATURE BIOTECHNOLOGY

Transient acquisition of pluripotency during somatic cell transdifferentiation with iPSC reprogramming factors

(2015) Itay Maza et al.   NATURE BIOTECHNOLOGY

Lineage conversion induced by pluripotency factors involves transient passage through an iPSC stage

(2015) Ori Bar-Nur et al.   NATURE BIOTECHNOLOGY

Replacing and safeguarding pancreatic β cells for diabetes

(2015) Jennifer E. Bruin et al.   Science Translational Medicine

Efficient Generation of NKX6-1+ Pancreatic Progenitors from Multiple Human Pluripotent Stem Cell Lines

(2015) M. Cristina Nostro et al.   Stem Cell Reports

Treating Diet-Induced Diabetes and Obesity with Human Embryonic Stem Cell-Derived Pancreatic Progenitor Cells and Antidiabetic Drugs

(2015) Jennifer E. Bruin et al.   Stem Cell Reports

Accelerated Maturation of Human Stem Cell-Derived Pancreatic Progenitor Cells into Insulin-Secreting Cells in Immunodeficient Rats Relative to Mice

(2015) Jennifer E. Bruin et al.   Stem Cell Reports

Generation of Functional Human Pancreatic β Cells In Vitro

(2014) Felicia W. Pagliuca et al.   CELL

Systematically labeling developmental stage-specific genes for the study of pancreatic β-cell differentiation from human embryonic stem cells

(2014) Haisong Liu et al.   CELL RESEARCH

Insulin-Producing Intestinal K Cells Protect Nonobese Diabetic Mice From Autoimmune Diabetes

(2014) Majid Mojibian et al.   GASTROENTEROLOGY

The global implications of diabetes and cancer

(2014) Yuankai Shi et al.   LANCET

Repurposing cAMP-Modulating Medications to Promote β-Cell Replication

(2014) Zhenshan Zhao et al.   MOLECULAR ENDOCRINOLOGY

Long-term persistence and development of induced pancreatic beta cells generated by lineage conversion of acinar cells

(2014) Weida Li et al.   NATURE BIOTECHNOLOGY

Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells

(2014) Alireza Rezania et al.   NATURE BIOTECHNOLOGY

Co-Transplantation of Endothelial Progenitor Cells and Pancreatic Islets to Induce Long-Lasting Normoglycemia in Streptozotocin-Treated Diabetic Rats

(2014) Paola Quaranta et al.   PLoS One

FOXO1 inhibition yields functional insulin-producing cells in human gut organoid cultures

(2014) Ryotaro Bouchi et al.   Nature Communications

De Novo Formation of Insulin-Producing “Neo-β Cell Islets” from Intestinal Crypts

(2014) Yi-Ju Chen et al.   Cell Reports

Dynamic Chromatin Remodeling Mediated by Polycomb Proteins Orchestrates Pancreatic Differentiation of Human Embryonic Stem Cells

(2013) Ruiyu Xie et al.   Cell Stem Cell

Adult Duct-Lining Cells Can Reprogram into β-like Cells Able to Counter Repeated Cycles of Toxin-Induced Diabetes

(2013) Keith Al-Hasani et al.   DEVELOPMENTAL CELL

Factors Expressed by Murine Embryonic Pancreatic Mesenchyme Enhance Generation of Insulin-Producing Cells From hESCs

(2013) T. Guo et al.   DIABETES

 -Cell Failure in Type 2 Diabetes: A Case of Asking Too Much of Too Few?

(2013) S. Costes et al.   DIABETES

Strategy for clinical setting in intramuscular and subcutaneous islet transplantation

(2013) Naoaki Sakata et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Maturation and function of human embryonic stem cell-derived pancreatic progenitors in macroencapsulation devices following transplant into mice

(2013) Jennifer E. Bruin et al.   DIABETOLOGIA

The reprogrammed pancreatic progenitor-like intermediate state of hepatic cells is more susceptible to pancreatic beta cell differentiation

(2013) Q. Wang et al.   JOURNAL OF CELL SCIENCE

Epigenomic plasticity enables human pancreatic α to β cell reprogramming

(2013) Nuria C. Bramswig et al.   JOURNAL OF CLINICAL INVESTIGATION

Small-Molecule Inducer of β Cell Proliferation Identified by High-Throughput Screening

(2013) Weijun Shen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Zwitterionic hydrogels implanted in mice resist the foreign-body reaction

(2013) Lei Zhang et al.   NATURE BIOTECHNOLOGY

Generation of Functional Insulin-Producing Cells from Neonatal Porcine Liver-Derived Cells by PDX1/VP16, BETA2/NeuroD and MafA

(2013) Dong-Sik Ham et al.   PLoS One

Characterization of polyhormonal insulin-producing cells derived in vitro from human embryonic stem cells

(2013) Jennifer E. Bruin et al.   Stem Cell Research

The Inactivation of Arx in Pancreatic α-Cells Triggers Their Neogenesis and Conversion into Functional β-Like Cells

(2013) Monica Courtney et al.   PLoS Genetics

Potent Induction Immunotherapy Promotes Long-Term Insulin Independence After Islet Transplantation in Type 1 Diabetes

(2012) M. D. Bellin et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Maturation of Human Embryonic Stem Cell-Derived Pancreatic Progenitors Into Functional Islets Capable of Treating Pre-existing Diabetes in Mice

(2012) A. Rezania et al.   DIABETES

Human ES-cell-derived cardiomyocytes electrically couple and suppress arrhythmias in injured hearts

(2012) Yuji Shiba et al.   NATURE

Generation of functional insulin-producing cells in the gut by Foxo1 ablation

(2012) Chutima Talchai et al.   NATURE GENETICS

A Scalable System for Production of Functional Pancreatic Progenitors from Human Embryonic Stem Cells

(2012) Thomas C. Schulz et al.   PLoS One

Adenosine kinase inhibition selectively promotes rodent and porcine islet  -cell replication

(2012) J. P. Annes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Generation of beta cells from human pluripotent stem cells: Potential for regenerative medicine

(2012) Maria Cristina Nostro et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Epigenetic Memory and Preferential Lineage-Specific Differentiation in Induced Pluripotent Stem Cells Derived from Human Pancreatic Islet Beta Cells

(2011) Ori Bar-Nur et al.   Cell Stem Cell

Stage-specific signaling through TGF  family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells

(2011) M. C. Nostro et al.   DEVELOPMENT

Context-specific  -to- -cell reprogramming by forced Pdx1 expression

(2011) Y.-P. Yang et al.   GENES & DEVELOPMENT

Cell-surface markers for the isolation of pancreatic cell types derived from human embryonic stem cells

(2011) Olivia G Kelly et al.   NATURE BIOTECHNOLOGY

Lgr5+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro

(2010) Nick Barker et al.   Cell Stem Cell

NKX6.1 Promotes PDX-1-Induced Liver to Pancreatic β-Cells Reprogramming

(2010) Shiraz Gefen-Halevi et al.   Cellular Reprogramming

Gastric Epithelial Stem Cells

(2010) Jason C. Mills et al.   GASTROENTEROLOGY

Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss

(2010) Fabrizio Thorel et al.   NATURE

Modern-Day Clinical Course of Type 1 Diabetes Mellitus After 30 Years' Duration

(2009)   ARCHIVES OF INTERNAL MEDICINE

The Ectopic Expression of Pax4 in the Mouse Pancreas Converts Progenitor Cells into α and Subsequently β Cells

(2009) Patrick Collombat et al.   CELL

Optimal implantation site for pancreatic islet transplantation

(2008) S. Merani et al.   BRITISH JOURNAL OF SURGERY

Pancreatic β-cell mass in European subjects with type 2 diabetes

(2008) J. Rahier et al.   DIABETES OBESITY & METABOLISM

In vivo reprogramming of adult pancreatic exocrine cells to β-cells

(2008) Qiao Zhou et al.   NATURE

Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo

(2008) Evert Kroon et al.   NATURE BIOTECHNOLOGY

Foreign body reaction to biomaterials

(2008) James M. Anderson et al.   SEMINARS IN IMMUNOLOGY