2.3 A resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition

Withaferin A Analogs That Target the AAA+ Chaperone p97

(2015) Shasha Tao et al.   ACS Chemical Biology

Inhibitors of the AAA+ Chaperone p97

(2015) Eli Chapman et al.   MOLECULES

2.2 A resolution cryo-EM structure of  -galactosidase in complex with a cell-permeant inhibitor

(2015) A. Bartesaghi et al.   SCIENCE

Clipping or Extracting: Two Ways to Membrane Protein Degradation

(2015) Dönem Avci et al.   TRENDS IN CELL BIOLOGY

Structure–Activity Study of Bioisosteric Trifluoromethyl and Pentafluorosulfanyl Indole Inhibitors of the AAA ATPase p97

(2015) Celeste Alverez et al.   ACS Medicinal Chemistry Letters

Proteotoxic crisis, the ubiquitin-proteasome system, and cancer therapy

(2014) Raymond J Deshaies   BMC BIOLOGY

Evaluating p97 Inhibitor Analogues for Their Domain Selectivity and Potency against the p97-p47 Complex

(2014) Chen-Jie Fang et al.   ChemMedChem

Structural Basis for Ovarian Tumor Domain-containing Protein 1 (OTU1) Binding to p97/Valosin-containing Protein (VCP)

(2014) Su Jin Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The VCP/p97 system at a glance: connecting cellular function to disease pathogenesis

(2014) H. Meyer et al.   JOURNAL OF CELL SCIENCE

Inter-ring rotations of AAA ATPase p97 revealed by electron cryomicroscopy

(2014) H. O. Yeung et al.   Open Biology

Structure-Activity Relationship Study Reveals ML240 and ML241 as Potent and Selective Inhibitors of p97 ATPase

(2013) Tsui-Fen Chou et al.   ChemMedChem

Altered Intersubunit Communication Is the Molecular Basis for Functional Defects of Pathogenic p97 Mutants

(2013) Wai Kwan Tang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death

(2013) Paola Magnaghi et al.   Nature Chemical Biology

High-Speed Atomic Force Microscopic Observation of ATP-Dependent Rotation of the AAA+ Chaperone p97

(2013) Kentaro Noi et al.   STRUCTURE

The Role of the N-Domain in the ATPase Activity of the Mammalian AAA ATPase p97/VCP

(2012) Hajime Niwa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alkylsulfanyl-1,2,4-triazoles, a New Class of Allosteric Valosine Containing Protein Inhibitors. Synthesis and Structure–Activity Relationships

(2012) Paolo Polucci et al.   JOURNAL OF MEDICINAL CHEMISTRY

Sorafenib-Mediated Targeting of the AAA+ ATPase p97/VCP Leads to Disruption of the Secretory Pathway, Endoplasmic Reticulum Stress, and Hepatocellular Cancer Cell Death

(2012) P. Yi et al.   MOLECULAR CANCER THERAPEUTICS

ATP Binding to p97/VCP D1 Domain Regulates Selective Recruitment of Adaptors to Its Proximal N-Domain

(2012) Wei Sheng Chia et al.   PLoS One

Development of p97 AAA ATPase inhibitors

(2011) Tsui-Fen Chou et al.   Autophagy

Critical Role of VCP/p97 in the Pathogenesis and Progression of Non-Small Cell Lung Carcinoma

(2011) Christopher W. Valle et al.   PLoS One

Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways

(2011) T.-F. Chou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hierarchical Binding of Cofactors to the AAA ATPase p97

(2011) Petra Hänzelmann et al.   STRUCTURE

A novel ATP-dependent conformation in p97 N–D1 fragment revealed by crystal structures of disease-related mutants

(2010) Wai Kwan Tang et al.   EMBO JOURNAL

Improved Structures of Full-Length p97, an AAA ATPase: Implications for Mechanisms of Nucleotide-Dependent Conformational Change

(2008) Jason M. Davies et al.   STRUCTURE