Orexin-A is Associated with Increases in Cerebrospinal Fluid Phosphorylated-Tau in Cognitively Normal Elderly Subjects

Orexin Neurons Are Necessary for the Circadian Control of REM Sleep

(2017) Sandor Kantor et al.   SLEEP

Human secreted tau increases amyloid-beta production

(2015) Jessica Bright et al.   NEUROBIOLOGY OF AGING

Amyloid precursor protein metabolism and inflammation markers in preclinical Alzheimer disease

(2015) Daniel Alcolea et al.   NEUROLOGY

REM sleep loss associated changes in orexin-A levels in discrete brain areas in rats

(2015) Rachna Mehta et al.   NEUROSCIENCE LETTERS

Orexin receptors exert a neuroprotective effect in Alzheimer’s disease (AD) via heterodimerization with GPR103

(2015) Julie Davies et al.   Scientific Reports

Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer’s disease

(2014) Jee Hoon Roh et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Amyloid-β diurnal pattern: possible role of sleep in Alzheimer's disease pathogenesis

(2014) Brendan P. Lucey et al.   NEUROBIOLOGY OF AGING

Sleep deprivation impairs memory, tau metabolism, and synaptic integrity of a mouse model of Alzheimer's disease with plaques and tangles

(2014) Antonio Di Meco et al.   NEUROBIOLOGY OF AGING

Exploring Alzheimer Molecular Pathology in Down's Syndrome Cerebrospinal Fluid

(2014) Erik Portelius et al.   Neurodegenerative Diseases

Orexinergic System Dysregulation, Sleep Impairment, and Cognitive Decline in Alzheimer Disease

(2014) Claudio Liguori et al.   JAMA Neurology

Effect of 1 Night of Total Sleep Deprivation on Cerebrospinal Fluid β-Amyloid 42 in Healthy Middle-Aged Men

(2014) Sharon Ooms et al.   JAMA Neurology

Hypocretin in cerebrospinal fluid is positively correlated with Tau and pTau

(2013) Michael Deuschle et al.   NEUROSCIENCE LETTERS

Cerebrospinal Fluid Melanin-Concentrating Hormone (MCH) and Hypocretin-1 (HCRT-1, Orexin-A) in Alzheimer’s Disease

(2013) Frank M. Schmidt et al.   PLoS One

Sleep Drives Metabolite Clearance from the Adult Brain

(2013) L. Xie et al.   SCIENCE

Modification of the Relationship of the Apolipoprotein E ε4 Allele to the Risk of Alzheimer Disease and Neurofibrillary Tangle Density by Sleep

(2013) Andrew S. P. Lim et al.   JAMA Neurology

Reciprocal interactions between sleep, circadian rhythms and Alzheimer's disease: Focus on the role of hypocretin and melatonin

(2012) Diane Slats et al.   AGEING RESEARCH REVIEWS

Association between Hypocretin-1 and Amyloid-β42 Cerebrospinal Fluid Levels in Alzheimer’s Disease and Healthy Controls

(2012) Diane Slats et al.   Current Alzheimer Research

Brain imaging and fluid biomarker analysis in young adults at genetic risk for autosomal dominant Alzheimer's disease in the presenilin 1 E280A kindred: a case-control study

(2012) Eric M Reiman et al.   LANCET NEUROLOGY

Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Reisa A. Sperling et al.   Alzheimers & Dementia

Effect of human cerebrospinal fluid sampling frequency on amyloid-β levels

(2011) Jinhe Li et al.   Alzheimers & Dementia

Effects of Age and Amyloid Deposition on Aβ Dynamics in the Human Central Nervous System

(2011) Yafei Huang   ARCHIVES OF NEUROLOGY

Development of the Brain's Default Mode Network from Wakefulness to Slow Wave Sleep

(2011) Philipp G. Sämann et al.   CEREBRAL CORTEX

Stages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years

(2011) Heiko Braak et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Neuronal activity regulates the regional vulnerability to amyloid-β deposition

(2011) Adam W Bero et al.   NATURE NEUROSCIENCE

Hypocretin (orexin) loss in Alzheimer's disease

(2011) Rolf Fronczek et al.   NEUROBIOLOGY OF AGING

The pathological process underlying Alzheimer’s disease in individuals under thirty

(2010) Heiko Braak et al.   ACTA NEUROPATHOLOGICA

Development of a Large-Scale Functional Brain Network during Human Non-Rapid Eye Movement Sleep

(2010) V. I. Spoormaker et al.   JOURNAL OF NEUROSCIENCE

Decoupling of the brain's default mode network during deep sleep

(2009) S. G. Horovitz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid-  Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle

(2009) J.-E. Kang et al.   SCIENCE

Evaluation of a Novel Ambulatory Device for Screening of Sleep Apnea

(2009) Pekka Tiihonen et al.   Telemedicine and e-Health

Self-Reported and Measured Sleep Duration

(2008) Diane S. Lauderdale et al.   EPIDEMIOLOGY

Robust and conventional neuropsychological norms: Diagnosis and prediction of age-related cognitive decline.

(2008) Susan De Santi et al.   NEUROPSYCHOLOGY

Aging-Related Sleep Changes

(2007) Joseph Roland D. Espiritu   CLINICS IN GERIATRIC MEDICINE