Schedule-dependent interaction between anticancer treatments

Robust synchronization of coupled circadian and cell cycle oscillators in single mammalian cells

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Phase locking and multiple oscillating attractors for the coupled mammalian clock and cell cycle

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A Nanoparticle-Based Combination Chemotherapy Delivery System for Enhanced Tumor Killing by Dynamic Rewiring of Signaling Pathways

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The p53 response in single cells is linearly correlated to the number of DNA breaks without a distinct threshold

(2013) Alexander Loewer et al.   BMC BIOLOGY

The Dynamics of Signaling as a Pharmacological Target

(2013) Marcelo Behar et al.   CELL

Tumor adaptation and resistance to RAF inhibitors

(2013) Piro Lito et al.   NATURE MEDICINE

Activation and control of p53 tetramerization in individual living cells

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Sequential Application of Anticancer Drugs Enhances Cell Death by Rewiring Apoptotic Signaling Networks

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Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells

(2012) Oliver D. K. Maddocks et al.   NATURE

MDM4 is a key therapeutic target in cutaneous melanoma

(2012) Agnieszka Gembarska et al.   NATURE MEDICINE

Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization

(2012) B. Graves et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p53 Dynamics Control Cell Fate

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MdmX Protein Is Essential for Mdm2 Protein-mediated p53 Polyubiquitination

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Basal Dynamics of p53 Reveal Transcriptionally Attenuated Pulses in Cycling Cells

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Circadian clock control of the cellular response to DNA damage

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Puzzling over MDM4–p53 network

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Identification and Characterization of the First Small Molecule Inhibitor of MDMX

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Mdm2 and Mdm4 Loss Regulates Distinct p53 Activities

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Recurrent Initiation: A Mechanism for Triggering p53 Pulses in Response to DNA Damage

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