Article
Cell Biology
Sheema Almozyan, James Coulton, Roya Babaei-Jadidi, Abdolrahman S. Nateri
Summary: Recent studies have indicated that FLYWCH1 may play a critical role in facilitating the recruitment of DNA-damage response proteins in the context of DNA damage and repair.
Article
Multidisciplinary Sciences
Hyun Ji Hwang, Seong Hwi Hong, Hong Sang Moon, Young Eun Yoon, Sung Yul Park
Summary: This study found that the combination therapy of ginsenoside and sunitinib significantly enhances the inhibition of cell viability in clear cell renal cell carcinoma (ccRCC) cells, and inhibits cell proliferation by inducing oxidative DNA damage.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Sonia Paget, Marion Dubuissez, Adeline Page, Vanessa Dehennaut, Ingrid Loison, Nathalie Spruyt, Dominique Leprince
Summary: HIC1 is a tumor suppressor gene encoding a transcriptional repressor that plays a role in the DNA-damage response. Specific posttranslational modifications, such as phosphorylation and acetylation, are crucial for the function of HIC1 and its activity in DNA repair. These modifications are essential for HIC1-mediated cellular response to repairable DNA double strand breaks.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Cell Biology
Vera Chesnokova, Svetlana Zonis, Athanasia Apostolou, Hannah Q. Estrada, Simon Knott, Kolja Wawrowsky, Kathrin Michelsen, Anat Ben-Shlomo, Robert Barrett, Vera Gorbunova, Katia Karalis, Shlomo Melmed, Kolja Wawrowsky, Kathrin Michelsen, Anat Ben-Shlomo, Robert Barrett, Vera Gorbunova, Katia Karalis, Shlomo Melmed
Summary: The study found that as individuals age, the level of non-pituitary growth hormone (npGH) in the body increases, leading to DNA damage accumulation. npGH can suppress p53 and weaken DNA repair response, accelerating DNA damage. Inhibiting npGH signaling could be a potential anti-aging therapy strategy.
Article
Cell Biology
Isabelle Trier, Elizabeth M. Black, Yoon Ki Joo, Lilian Kabeche
Summary: We have found that ATR kinase, a master regulator of the DNA damage response, protects CENP-A protein occupancy at centromeres during interphase independent of DNA damage. Furthermore, ATR-dependent phosphorylation of DAXX protein regulates CENP-A occupancy at centromeres and DAXX localization. Lastly, acute ATR inhibition during interphase leads to kinetochore formation defects and an increased rate of lagging chromosomes. These findings highlight a mechanism by which ATR protects centromere identity and genome stability.
Article
Cell Biology
Chunyun Zhang, Yingjie Guan, Jianan Zou, Xu Yang, Georgia Bayliss, Shougang Zhuang
Summary: This study reveals the role of MLL1 in acute kidney injury (AKI) induced by cisplatin. The inhibition of the MLL1/WDR5 complex using MM102 improved renal function, attenuated tubular injury and apoptosis, and suppressed the phosphorylation of p53 and the decrease of E-cadherin expression. MM102 also effectively inhibited the DNA damage response triggered by cisplatin.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Samuel B. Bader, Tiffany S. Ma, Charlotte J. Simpson, Jiachen Liang, Sakura Eri B. Maezono, Monica M. Olcina, Francesca M. Buffa, Ester M. Hammond
Summary: This study demonstrates that fluctuating hypoxic conditions inducing replication catastrophe lead to increased expression and activity of APOBEC3B, contributing to the accumulation of APOBEC-mediated mutations. In contrast, stable hypoxic conditions do not significantly impact APOBEC3B. The number of APOBEC-mediated mutations in patient tumors is closely correlated with a hypoxia signature, indicating that hypoxia-induced replication catastrophe drives genomic instability in tumors through increasing the activity of APOBEC3B.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Cell Biology
Qiongyu Yan, Bin Zhang, Xi Ling, Bin Zhu, Shenghui Mei, Hua Yang, Dongjie Zhang, Jiping Huo, Zhigang Zhao
Summary: This study reveals the role of CTLA-4 as an immunomodulator in the DNA damage response. It activates ATM by binding to the ATM inhibitor protein 2A, exacerbates DNA damage response, and induces cell apoptosis. This provides important insights into the mechanisms by which T cells maintain immune function under high-stress conditions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Food Science & Technology
Silu Hou, Yuqiang Cheng, Zhaofei Wang, Luming Xia, Jian Wang, Hengan Wang, Jianhe Sun, Jingjiao Ma, Yaxian Yan
Summary: This study investigated the toxic effects of deoxynivalenol (DON) on gastric mucosal epithelial cells and found that DON can inhibit cell activity, induce DNA damage, apoptosis, and cell cycle arrest. These findings are important for understanding the cytotoxicity and gastric diseases caused by DON.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Editorial Material
Genetics & Heredity
Hartwig Visser, Adam D. Thomas
Summary: DNA damage-induced miRNAs are important in the DNA damage response, influencing cell fate. However, it is still unclear who is in charge in this process.
TRENDS IN GENETICS
(2021)
Article
Biochemistry & Molecular Biology
Kimiyoshi Yano, Ryou-U Takahashi, Bunsyo Shiotani, Junko Abe, Tomoki Shidooka, Yuki Sudo, Yusuke Yamamoto, Shisei Kan, Hiroki Sakagami, Hidetoshi Tahara
Summary: PRPF19 is identified as a critical regulator of cellular senescence in normal human fibroblasts by modulating MDM4 splicing and p53 activity, leading to induction of p53-dependent cellular senescence.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Biology
Yang Wei, Ruilin Bao, Le Hu, Yanqing Geng, Xuemei Chen, Yixian Wen, Yingxiong Wang, Mao Qin, Yue Zhang, Xueqing Liu
Summary: This study evaluated the reproductive toxicity of two-dimensional ultrathin Ti3C2 nanosheets in the testes. It found that exposure to Ti3C2 nanosheets caused defects in spermatogenic function, possibly due to oxidative stress and DNA damage.
Article
Cell Biology
Yang Wang, Tianyu Yu, Yi Han, Yazhi He, Yiran Song, Leiming Guo, Liwei An, Chunying Yang, Feng Wang
Summary: This study reveals the key regulatory role of Mad2 phosphorylation in checkpoint defects and DNA damage repair in ATM-deficient cells. ATM negatively regulates the phosphorylation of Mad2, causing decreased DNA damage repair capacity and resistance to cancer cell radiotherapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Pengyi Yan, Zixuan Li, Junhao Xiong, Zilong Geng, Weiting Wei, Yan Zhang, Gengze Wu, Tao Zhuang, Xiaoyu Tian, Zhijie Liu, Junling Liu, Kun Sun, Fengyuan Chen, Yuzhen Zhang, Chunyu Zeng, Yu Huang, Bing Zhang
Summary: In this study, LARP7 is identified as an aging antagonist, and the ATM-LARP7-SIRT1-p53/p65 pathway plays a crucial role in DNA damage response-mediated cellular senescence and atherosclerosis.
Article
Biochemistry & Molecular Biology
Karla Gisel Calderon-Gonzalez, Ixaura Medina-Medina, Lucia Haronikova, Lenka Hernychova, Ondrej Bonczek, Lukas Uhrik, Vaclav Hrabal, Borivoj Vojtesek, Robin Fahraeus, Jesus Hernandez-Monge, Vanesa Olivares-Illana
Summary: HDMX and HDM2 are essential proteins in the cell, with HDMX playing a role in regulating the activity of p53. Despite having high similarity in their RING domains, HDMX does not possess E3 ligase activity like HDM2. However, HDMX is still important for the proper poly-ubiquitination of p53. The phosphorylation of HDM2 at serine 395 changes its conformation and activity, but the effect of phosphorylation on HDMX is still unknown. In this study, the researchers investigate the conformation and E3 ligase activity of HDMX, as well as its binding with p53.
BIOSCIENCE REPORTS
(2022)