Solubis: a webserver to reduce protein aggregation through mutation

Structural hot spots for the solubility of globular proteins

(2016) Ashok Ganesan et al.   Nature Communications

Solubis: optimize your protein: Fig. 1.

(2015) Greet De Baets et al.   BIOINFORMATICS

Predicting aggregation-prone sequences in proteins

(2014) Greet De Baets et al.   Essays in Biochemistry

A Genome-Wide Sequence–Structure Analysis Suggests Aggregation Gatekeepers Constitute an Evolutionary Constrained Functional Class

(2014) Greet De Baets et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure-energy-based predictions and network modelling of RASopathy and cancer missense mutations

(2014) C. Kiel et al.   Molecular Systems Biology

A Consensus Method for the Prediction of ‘Aggregation-Prone’ Peptides in Globular Proteins

(2013) Antonios C. Tsolis et al.   PLoS One

Sweeping Away Protein Aggregation with Entropic Bristles: Intrinsically Disordered Protein Fusions Enhance Soluble Expression

(2012) Aaron A. Santner et al.   BIOCHEMISTRY

Biophysical characterisation of thermal-induced precipitates of recombinant anthrax protective antigen: Evidence for kinetically trapped unfolding domains in solid-state

(2012) Ashok Ganesan et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

α-Galactosidase Aggregation Is a Determinant of Pharmacological Chaperone Efficacy on Fabry Disease Mutants

(2012) Aleksandra Siekierska et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prediction of amyloid aggregation in vivo

(2011) Mattia Belli et al.   EMBO REPORTS

A novel Escherichia coli solubility enhancer protein for fusion expression of aggregation-prone heterologous proteins

(2011) Jong-Am Song et al.   ENZYME AND MICROBIAL TECHNOLOGY

Gain of function of mutant p53 by coaggregation with multiple tumor suppressors

(2011) Jie Xu et al.   Nature Chemical Biology

Coupling of Aggregation and Immunogenicity in Biotherapeutics: T- and B-Cell Immune Epitopes May Contain Aggregation-Prone Regions

(2011) Sandeep Kumar et al.   PHARMACEUTICAL RESEARCH

An Evolutionary Trade-Off between Protein Turnover Rate and Protein Aggregation Favors a Higher Aggregation Propensity in Fast Degrading Proteins

(2011) Greet De Baets et al.   PLoS Computational Biology

Predictive tools for stabilization of therapeutic proteins

(2010) Vladimir Voynov et al.   mAbs

A series of PDB related databases for everyday needs

(2010) R. P. Joosten et al.   NUCLEIC ACIDS RESEARCH

Potential Aggregation-Prone Regions in Complementarity-Determining Regions of Antibodies and Their Contribution Towards Antigen Recognition: A Computational Analysis

(2010) Xiaoling Wang et al.   PHARMACEUTICAL RESEARCH

A Relationship between mRNA Expression Levels and Protein Solubility in E. coli

(2009) Gian Gaetano Tartaglia et al.   JOURNAL OF MOLECULAR BIOLOGY

Association of Highly Compact Type II Diabetes Related Islet Amyloid Polypeptide Intermediate Species at Physiological Temperature Revealed by Diffusion NMR Spectroscopy

(2009) Ronald Soong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Assessing computational methods for predicting protein stability upon mutation: good on average but not in the details

(2009) V. Potapov et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Amyloidogenic Regions and Interaction Surfaces Overlap in Globular Proteins Related to Conformational Diseases

(2009) Virginia Castillo et al.   PLoS Computational Biology

Accurate Prediction of DnaK-Peptide Binding via Homology Modelling and Experimental Data

(2009) Joost Van Durme et al.   PLoS Computational Biology

Solubility enhancement of aggregation-prone heterologous proteins by fusion expression using stress-responsive Escherichia coli protein, RpoS

(2008) Jin-Seung Park et al.   BMC BIOTECHNOLOGY

Amyloid formation by globular proteins under native conditions

(2008) Fabrizio Chiti et al.   Nature Chemical Biology

Adapting Proteostasis for Disease Intervention

(2008) William E. Balch et al.   SCIENCE