The genomic basis of adaptation to the fitness cost of rifampicin resistance inPseudomonas aeruginosa

Evolutionary Transition from Pathogenicity to Commensalism: Global Regulator Mutations Mediate Fitness Gains through Virulence Attenuation

(2015) Gunther Jansen et al.   MOLECULAR BIOLOGY AND EVOLUTION

Evolutionary consequences of drug resistance: shared principles across diverse targets and organisms

(2015) Diarmaid Hughes et al.   NATURE REVIEWS GENETICS

Unraveling Mycobacterium tuberculosis genomic diversity and evolution in Lisbon, Portugal, a highly drug resistant setting

(2014) João Perdigão et al.   BMC GENOMICS

Fitness Is Strongly Influenced by Rare Mutations of Large Effect in a Microbial Mutation Accumulation Experiment

(2014) K. Heilbron et al.   GENETICS

Linking System-Wide Impacts of RNA Polymerase Mutations to the Fitness Cost of Rifampin Resistance in Pseudomonas aeruginosa

(2014) Qin Qi et al.   mBio

Positive selection and compensatory adaptation interact to stabilize non-transmissible plasmids

(2014) A. San Millan et al.   Nature Communications

The Genomic Landscape of Compensatory Evolution

(2014) Béla Szamecz et al.   PLOS BIOLOGY

Genetic characterization of compensatory evolution in strains carrying rpoB Ser531Leu, the rifampicin resistance mutation most frequently found in clinical isolates

(2013) G. Brandis et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Genetic variation of a bacterial pathogen within individuals with cystic fibrosis provides a record of selective pressures

(2013) Tami D Lieberman et al.   NATURE GENETICS

Genomic analysis identifies targets of convergent positive selection in drug-resistant Mycobacterium tuberculosis

(2013) Maha R Farhat et al.   NATURE GENETICS

The genetic causes of convergent evolution

(2013) David L. Stern   NATURE REVIEWS GENETICS

Bacterial Quorum Sensing: Its Role in Virulence and Possibilities for Its Control

(2013) S. T. Rutherford et al.   Cold Spring Harbor Perspectives in Medicine

Putative Compensatory Mutations in the rpoC Gene of Rifampin-Resistant Mycobacterium tuberculosis Are Associated with Ongoing Transmission

(2012) M. de Vos et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Microevolution of extensively drug-resistant tuberculosis in Russia

(2012) N. Casali et al.   GENOME RESEARCH

Fitness-compensatory mutations in rifampicin-resistant RNA polymerase

(2012) Gerrit Brandis et al.   MOLECULAR MICROBIOLOGY

Evolutionary dynamics of Staphylococcus aureus during progression from carriage to disease

(2012) B. C. Young et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Molecular Diversity of Adaptive Convergence

(2012) O. Tenaillon et al.   SCIENCE

Whole genome analysis of linezolid resistance in Streptococcus pneumoniae reveals resistance and compensatory mutations

(2011) Dewan S Billal et al.   BMC GENOMICS

FITNESS RECOVERY AND COMPENSATORY EVOLUTION IN NATURAL MUTANT LINES OF C. ELEGANS

(2011) Suzanne Estes et al.   EVOLUTION

Population biological principles of drug-resistance evolution in infectious diseases

(2011) Pia Abel zur Wiesch et al.   LANCET INFECTIOUS DISEASES

Parallel bacterial evolution within multiple patients identifies candidate pathogenicity genes

(2011) Tami D Lieberman et al.   NATURE GENETICS

Evolutionary paths to antibiotic resistance under dynamically sustained drug selection

(2011) Erdal Toprak et al.   NATURE GENETICS

Whole-genome sequencing of rifampicin-resistant Mycobacterium tuberculosis strains identifies compensatory mutations in RNA polymerase genes

(2011) Iñaki Comas et al.   NATURE GENETICS

Mutation Rate Inferred From Synonymous Substitutions in a Long-Term Evolution Experiment With Escherichia coli

(2011) Sébastien Wielgoss et al.   G3-Genes Genomes Genetics

Frequent Beneficial Mutations during Single-Colony Serial Transfer of Streptococcus pneumoniae

(2011) Kathleen E. Stevens et al.   PLoS Genetics

Compensation of Fitness Costs and Reversibility of Antibiotic Resistance Mutations

(2010) P. Schulz zur Wiesch et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Diminishing Returns From Beneficial Mutations and Pervasive Epistasis Shape the Fitness Landscape for Rifampicin Resistance in Pseudomonas aeruginosa

(2010) R. C. MacLean et al.   GENETICS

Error-prone initiation factor 2 mutations reduce the fitness cost of antibiotic resistance

(2010) Anna Zorzet et al.   MOLECULAR MICROBIOLOGY

The population genetics of antibiotic resistance: integrating molecular mechanisms and treatment contexts

(2010) R. Craig MacLean et al.   NATURE REVIEWS GENETICS

Antibiotic resistance and its cost: is it possible to reverse resistance?

(2010) Dan I. Andersson et al.   NATURE REVIEWS MICROBIOLOGY

Determination of the regulon and identification of novel mRNA targets ofPseudomonas aeruginosaRsmA

(2009) Anja Brencic et al.   MOLECULAR MICROBIOLOGY

Genomic Diversity among Drug Sensitive and Multidrug Resistant Isolates of Mycobacterium tuberculosis with Identical DNA Fingerprints

(2009) Stefan Niemann et al.   PLoS One

Compensatory mutations are repeatable and clustered within proteins

(2009) B. H. Davis et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Mutational neighbourhood and mutation supply rate constrain adaptation in Pseudomonas aeruginosa

(2009) A. R. Hall et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Restored fitness leads to long-term persistence of resistant Bacteroides strains in the human intestine

(2008) Sonja Löfmark et al.   ANAEROBE

Analysis of the fitness effect of compensatory mutations

(2008) Liqing Zhang et al.   HFSP Journal

Colonization dynamics of ampicillin-resistant Escherichia coli in the infantile colonic microbiota

(2008) N. Karami et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY