Ion channels find a pathway for therapeutic success: Table 1.

Novel cell-free high-throughput screening method for pharmacological tools targeting K+channels

(2016) Zhenwei Su et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cardiovascular Safety Outcome Trials: A meeting report from the Cardiac Safety Research Consortium

(2015) Philip T. Sager et al.   AMERICAN HEART JOURNAL

Novel screening techniques for ion channel targeting drugs

(2015) Alison Obergrussberger et al.   Channels

HTS assays for developing the molecular pharmacology of ion channels

(2014) Owen B McManus   CURRENT OPINION IN PHARMACOLOGY

Targeting cardiac potassium channels for state-of-the-art drug discovery

(2014) Kenneth B Walsh   Expert Opinion on Drug Discovery

Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel

(2014) Stephen G. Brohawn et al.   NATURE

BK channel activators and their therapeutic perspectives

(2014) Bo H. Bentzen et al.   Frontiers in Physiology

A High-Throughput Functional Screen Identifies Small Molecule Regulators of Temperature- and Mechano-Sensitive K2P Channels

(2013) Sviatoslav N. Bagriantsev et al.   ACS Chemical Biology

Targeting the inward-rectifier potassium channel ROMK in cardiovascular disease

(2013) Maria L Garcia et al.   CURRENT OPINION IN PHARMACOLOGY

X-ray structure of the mammalian GIRK2–βγ G-protein complex

(2013) Matthew R. Whorton et al.   NATURE

The Inwardly Rectifying Potassium Channel Kir1.1: Development of Functional Assays to Identify and Characterize Channel Inhibitors

(2012) John P. Felix et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Crystal Structure of the Calcium Release-Activated Calcium Channel Orai

(2012) X. Hou et al.   SCIENCE

How to improve R&D productivity: the pharmaceutical industry's grand challenge

(2010) Steven M. Paul et al.   NATURE REVIEWS DRUG DISCOVERY

Development of the Predictor hERG Fluorescence Polarization Assay Using a Membrane Protein Enrichment Approach

(2008) David R. Piper et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Miniaturization and HTS of a FRET-Based Membrane Potential Assay for Kir Channel Inhibitors

(2008) Kelli Solly et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES