Novel screening techniques for ion channel targeting drugs

Development of Automated Patch Clamp Assay for Evaluation of α7 Nicotinic Acetylcholine Receptor Agonists in Automated QPatch-16

(2015) Yuchen Hao et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Pro-inflammatory TNFα and IL-1β differentially regulate the inflammatory phenotype of brain microvascular endothelial cells

(2015) Simon J. O’Carroll et al.   Journal of Neuroinflammation

CiPA: Ongoing testing, future qualification procedures, and pending issues

(2015) Icilio Cavero et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Screening system for drug-induced arrhythmogenic risk combining a patch clamp and heart simulator

(2015) J.-i. Okada et al.   Science Advances

Assessment of temperature-induced hERG channel blockade variation by drugs

(2014) Rahul R. Kauthale et al.   JOURNAL OF APPLIED TOXICOLOGY

An improved method for determining virucidal efficacy of a chemical disinfectant using an electrical impedance assay

(2014) Karen Ebersohn et al.   JOURNAL OF VIROLOGICAL METHODS

Functional regeneration of intraspinal connections in a new in vitro model

(2014) M. Heidemann et al.   NEUROSCIENCE

Red cell investigations: Art and artefacts

(2013) Giampaolo Minetti et al.   BLOOD REVIEWS

A novel assay for high-throughput screening of anti-Alzheimer’s disease drugs to determine their efficacy by real-time monitoring of changes in PC12 cell proliferation

(2013) XUE-QIN HOU et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Multi-electrode array technologies for neuroscience and cardiology

(2013) Micha E. Spira et al.   Nature Nanotechnology

A public–private consortium advances cardiac safety evaluation: Achievements of the HESI Cardiac Safety Technical Committee

(2013) Jennifer B. Pierson et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Minimized cell usage for stem cell-derived and primary cells on an automated patch clamp system

(2013) Nadine Becker et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Low-density plating is sufficient to induce cardiac hypertrophy and electrical remodeling in highly purified human iPS cell-derived cardiomyocytes

(2013) Mai Uesugi et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Dynamic monitoring of beating periodicity of stem cell-derived cardiomyocytes as a predictive tool for preclinical safety assessment

(2011) Yama A Abassi et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Chimeric Approach Reveals That Differences in the TRPV1 Pore Domain Determine Species-specific Sensitivity to Block of Heat Activation

(2011) Marianthi Papakosta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Voltage-gated sodium channel (NaV) protein dissection creates a set of functional pore-only proteins

(2011) D. Shaya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Automated electrophysiology makes the pace for cardiac ion channel safety screening

(2011) Clemens Möller   Frontiers in Pharmacology

State-of-the-art automated patch clamp devices: heat activation, action potentials, and high throughput in ion channel screening

(2011) Sonja Stoelzle   Frontiers in Pharmacology

Impact of new technologies for cellular screening along the drug value chain

(2010) Clemens Möller et al.   DRUG DISCOVERY TODAY

Thermosensitive transient receptor potential channels in human corneal epithelial cells

(2010) Stefan Mergler et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Planar Patch Clamp Approach to Characterize Ionic Currents from Intact Lysosomes

(2010) M. Schieder et al.   Science Signaling

Port-a-Patch and Patchliner: High Fidelity Electrophysiology for Secondary Screening and Safety Pharmacology

(2009) Niels Fertig et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Robotic multiwell planar patch-clamp for native and primary mammalian cells

(2009) Carol J Milligan et al.   Nature Protocols

Interactions, Functions, and Independence of Plasma Membrane STIM1 and TRPC1 in Vascular Smooth Muscle Cells

(2008) Jing Li et al.   CIRCULATION RESEARCH

Preclinical assessment of cardiac toxicity

(2008) Ralf Kettenhofen et al.   DRUG DISCOVERY TODAY

Ion Channels as Drug Targets: The Next GPCRs

(2008) Gregory J. Kaczorowski et al.   JOURNAL OF GENERAL PHYSIOLOGY

High-throughput electrophysiology: an emerging paradigm for ion-channel screening and physiology

(2008) John Dunlop et al.   NATURE REVIEWS DRUG DISCOVERY