Architecture of a minimal signaling pathway explains the T-cell response to a 1 million-fold variation in antigen affinity and dose
Published 2016 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Architecture of a minimal signaling pathway explains the T-cell response to a 1 million-fold variation in antigen affinity and dose
Authors
Keywords
-
Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 113, Issue 43, Pages E6630-E6638
Publisher
Proceedings of the National Academy of Sciences
Online
2016-10-05
DOI
10.1073/pnas.1608820113
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Multisite Phosphorylation Modulates the T Cell Receptor ζ -Chain Potency but not the Switchlike Response
- (2016) Himadri Mukhopadhyay et al. BIOPHYSICAL JOURNAL
- Control of T cell antigen reactivity via programmed TCR downregulation
- (2016) Alena M Gallegos et al. NATURE IMMUNOLOGY
- Tuning Sensitivity of CAR to EGFR Density Limits Recognition of Normal Tissue While Maintaining Potent Antitumor Activity
- (2015) H. G. Caruso et al. CANCER RESEARCH
- T cell receptor binding affinity governs the functional profile of cancer-specific CD8+T cells
- (2015) M. P. Tan et al. CLINICAL AND EXPERIMENTAL IMMUNOLOGY
- K33-linked polyubiquitination of Zap70 by Nrdp1 controls CD8+ T cell activation
- (2015) Mingjin Yang et al. NATURE IMMUNOLOGY
- Structural interplay between germline interactions and adaptive recognition determines the bandwidth of TCR-peptide-MHC cross-reactivity
- (2015) Jarrett J Adams et al. NATURE IMMUNOLOGY
- Models in biology: ‘accurate descriptions of our pathetic thinking’
- (2014) Jeremy Gunawardena BMC BIOLOGY
- Coreceptor Scanning by the T Cell Receptor Provides a Mechanism for T Cell Tolerance
- (2014) Ondrej Stepanek et al. CELL
- A THEMIS:SHP1 complex promotes T-cell survival
- (2014) W. Paster et al. EMBO JOURNAL
- Specific recycling receptors are targeted to the immune synapse by the intraflagellar transport system
- (2014) F. Finetti et al. JOURNAL OF CELL SCIENCE
- Polarized release of T-cell-receptor-enriched microvesicles at the immunological synapse
- (2014) Kaushik Choudhuri et al. NATURE
- Evolving phenotypic networks in silico
- (2014) Paul François SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- An induced rebinding model of antigen discrimination
- (2014) Omer Dushek et al. TRENDS IN IMMUNOLOGY
- Reverse engineering and identification in systems biology: strategies, perspectives and challenges
- (2013) A. F. Villaverde et al. Journal of the Royal Society Interface
- Anti-CD22-chimeric antigen receptors targeting B-cell precursor acute lymphoblastic leukemia
- (2012) W. Haso et al. BLOOD
- A Broad Range of Self-Reactivity Drives Thymic Regulatory T Cell Selection to Limit Responses to Self
- (2012) Hyang-Mi Lee et al. IMMUNITY
- Interplay between T Cell Receptor Binding Kinetics and the Level of Cognate Peptide Presented by Major Histocompatibility Complexes Governs CD8+T Cell Responsiveness
- (2012) Melita Irving et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Human T cells expressing affinity-matured TCR display accelerated responses but fail to recognize low density of MHC-peptide antigen
- (2011) S. Thomas et al. BLOOD
- Strength of TCR-Peptide/MHC Interactions and In Vivo T Cell Responses
- (2011) E. Corse et al. JOURNAL OF IMMUNOLOGY
- Antigen Potency and Maximal Efficacy Reveal a Mechanism of Efficient T Cell Activation
- (2011) O. Dushek et al. Science Signaling
- Robust Network Topologies for Generating Switch-Like Cellular Responses
- (2011) Najaf A. Shah et al. PLoS Computational Biology
- Dependence of T Cell Antigen Recognition on T Cell Receptor-Peptide MHC Confinement Time
- (2010) Milos Aleksic et al. IMMUNITY
- TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo
- (2010) Rachel A. Gottschalk et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Evidence for a TCR Affinity Threshold Delimiting Maximal CD8 T Cell Function
- (2010) D. A. Schmid et al. JOURNAL OF IMMUNOLOGY
- Fast on-rates allow short dwell time ligands to activate T cells
- (2010) C. C. Govern et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- TRIM5 Suppresses Cross-Species Transmission of a Primate Immunodeficiency Virus and Selects for Emergence of Resistant Variants in the New Species
- (2010) Andrea Kirmaier et al. PLOS BIOLOGY
- T Cell Activation
- (2009) Jennifer E. Smith-Garvin et al. Annual Review of Immunology
- Defining Network Topologies that Can Achieve Biochemical Adaptation
- (2009) Wenzhe Ma et al. CELL
- The promise and potential pitfalls of chimeric antigen receptors
- (2009) Michel Sadelain et al. CURRENT OPINION IN IMMUNOLOGY
- The Impact of TCR-Binding Properties and Antigen Presentation Format on T Cell Responsiveness
- (2009) A. S. Chervin et al. JOURNAL OF IMMUNOLOGY
- Dominant Role of Antigen Dose in CD4+Foxp3+ Regulatory T Cell Induction and Expansion
- (2009) M. S. Turner et al. JOURNAL OF IMMUNOLOGY
- Distilling Free-Form Natural Laws from Experimental Data
- (2009) Michael Schmidt et al. SCIENCE
- Approximate Bayesian computation scheme for parameter inference and model selection in dynamical systems
- (2008) T. Toni et al. Journal of the Royal Society Interface
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreDiscover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversation