Engineering a long-acting, potent GLP-1 analog for microstructure-based transdermal delivery

Design of Potent and Proteolytically Stable Oxyntomodulin Analogs

(2016) Avinash Muppidi et al.   ACS Chemical Biology

Peptide therapeutics: current status and future directions

(2015) Keld Fosgerau et al.   DRUG DISCOVERY TODAY

Discovery of the Once-Weekly Glucagon-Like Peptide-1 (GLP-1) Analogue Semaglutide

(2015) Jesper Lau et al.   JOURNAL OF MEDICINAL CHEMISTRY

A biomimetic approach for enhancing the in vivo half-life of peptides

(2015) Sravan C Penchala et al.   Nature Chemical Biology

Functional human antibody CDR fusions as long-acting therapeutic endocrine agonists

(2015) Tao Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fabrication of cell culture-derived influenza vaccine dissolvable microstructures and evaluation of immunogenicity in guinea pigs

(2015) Amanda Bonificio et al.   VACCINE

Rational Design of a Humanized Glucagon-Like Peptide-1 Receptor Agonist Antibody

(2014) Yong Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Multivalent Antiviral XTEN–Peptide Conjugates with Long in Vivo Half-Life and Enhanced Solubility

(2014) Sheng Ding et al.   BIOCONJUGATE CHEMISTRY

Pilot study of liraglutide effects in non-alcoholic steatohepatitis and non-alcoholic fatty liver disease with glucose intolerance in Japanese patients (LEAN-J)

(2014) Yuichiro Eguchi et al.   HEPATOLOGY RESEARCH

Glucagon-like peptide-1 receptors in the brain: controlling food intake and body weight

(2014) Laurie L. Baggio et al.   JOURNAL OF CLINICAL INVESTIGATION

Hydrocarbon-Stapled Peptides: Principles, Practice, and Progress

(2014) Loren D. Walensky et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Potent α/β-Peptide Analogue of GLP-1 with Prolonged Action in Vivo

(2014) Lisa M. Johnson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Backbone modification of a polypeptide drug alters duration of action in vivo

(2014) Ross W Cheloha et al.   NATURE BIOTECHNOLOGY

Self-hydrolyzing maleimides improve the stability and pharmacological properties of antibody-drug conjugates

(2014) Robert P Lyon et al.   NATURE BIOTECHNOLOGY

Overcoming the challenges in administering biopharmaceuticals: formulation and delivery strategies

(2014) Samir Mitragotri et al.   NATURE REVIEWS DRUG DISCOVERY

A New Option for Glycemic Control: Insulin Degludec, a New-Generation Basal Insulin with an Ultralong Duration of Action

(2013) Scott R. Drab et al.   PHARMACOTHERAPY

Stapled α−helical peptide drug development: A potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy

(2013) Yong S. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Questioning the use of PEGylation for drug delivery

(2013) Johan J. F. Verhoef et al.   Drug Delivery and Translational Research

Peptide lipidation stabilizes structure to enhance biological function

(2013) Brian P. Ward et al.   Molecular Metabolism

Polymer–drug conjugates: Origins, progress to date and future directions

(2012) Jindřich Kopeček   ADVANCED DRUG DELIVERY REVIEWS

Rational Design of Proteolytically Stable, Cell-Permeable Peptide-Based Selective Mcl-1 Inhibitors

(2012) Avinash Muppidi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

GLP-1 receptor agonists for individualized treatment of type 2 diabetes mellitus

(2012) Juris J. Meier   Nature Reviews Endocrinology

The structure and function of the glucagon-like peptide-1 receptor and its ligands

(2011) Dan Donnelly   BRITISH JOURNAL OF PHARMACOLOGY

Exenatide in the Treatment of Diabetic Patients With Non-Alcoholic Steatohepatitis: A Case Series

(2010) Patrick R Kenny et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Poly(ethylene glycol) in Drug Delivery: Pros and Cons as Well as Potential Alternatives

(2010) Katrin Knop et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dissolving polymer microneedle patches for influenza vaccination

(2010) Sean P Sullivan et al.   NATURE MEDICINE

Transdermal Delivery of Macromolecules Using Solid-State Biodegradable Microstructures

(2010) Janet R. Wendorf et al.   PHARMACEUTICAL RESEARCH

Downsizing human, bacterial, and viral proteins to short water-stable alpha helices that maintain biological potency

(2010) R. S. Harrison et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A recombinant polypeptide extends the in vivo half-life of peptides and proteins in a tunable manner

(2009) Volker Schellenberger et al.   NATURE BIOTECHNOLOGY

Crystal Structure of the Ligand-bound Glucagon-like Peptide-1 Receptor Extracellular Domain

(2008) Steffen Runge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transdermal drug delivery

(2008) Mark R Prausnitz et al.   NATURE BIOTECHNOLOGY

Structural diversity of G protein-coupled receptors and significance for drug discovery

(2008) Malin C. Lagerström et al.   NATURE REVIEWS DRUG DISCOVERY

Peptoids that mimic the structure, function, and mechanism of helical antimicrobial peptides

(2008) N. P. Chongsiriwatana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA