Tetra-O-Methyl Nordihydroguaiaretic Acid Broadly Suppresses Cancer Metabolism and Synergistically Induces Strong Anticancer Activity in Combination with Etoposide, Rapamycin and UCN-01

Broad Anti-tumor Activity of a Small Molecule that Selectively Targets the Warburg Effect and Lipogenesis

(2015) Colin A. Flaveny et al.   CANCER CELL

Sp1 and the ‘hallmarks of cancer’

(2015) Kate Beishline et al.   FEBS Journal

Phase I study of the novel Cdc2/CDK1 and AKT inhibitor terameprocol in patients with advanced leukemias

(2014) R. Tibes et al.   INVESTIGATIONAL NEW DRUGS

CHAC1/MGC4504 Is a Novel Proapoptotic Component of the Unfolded Protein Response, Downstream of the ATF4-ATF3-CHOP Cascade

(2014) I. N. Mungrue et al.   JOURNAL OF IMMUNOLOGY

Lipid Catabolism via CPT1 as a Therapeutic Target for Prostate Cancer

(2014) I. R. Schlaepfer et al.   MOLECULAR CANCER THERAPEUTICS

Asparagine synthetase: regulation by cell stress and involvement in tumor biology

(2013) Mukundh N. Balasubramanian et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

LKB1 and AMPK and the cancer-metabolism link - ten years after

(2013) D Hardie et al.   BMC BIOLOGY

Review of Poly (ADP-ribose) Polymerase (PARP) Mechanisms of Action and Rationale for Targeting in Cancer and Other Diseases

(2013) Julio Morales et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Identification of a Tissue-Specific, C/EBP -Dependent Pathway of Differentiation for Murine Peritoneal Macrophages

(2013) D. W. Cain et al.   JOURNAL OF IMMUNOLOGY

Glutathione Transferases as Targets for Cancer Therapy

(2012) Paolo Ruzza et al.   Anti-Cancer Agents in Medicinal Chemistry

Sestrin2 integrates Akt and mTOR signaling to protect cells against energetic stress-induced death

(2012) I Ben-Sahra et al.   CELL DEATH AND DIFFERENTIATION

Mammalian proapoptotic factor ChaC1 and its homologues function as γ-glutamyl cyclotransferases acting specifically on glutathione

(2012) Akhilesh Kumar et al.   EMBO REPORTS

BNip3 Regulates Mitochondrial Function and Lipid Metabolism in the Liver

(2012) D. Glick et al.   MOLECULAR AND CELLULAR BIOLOGY

How cancer metabolism is tuned for proliferation and vulnerable to disruption

(2012) Almut Schulze et al.   NATURE

Therapeutic targets in cancer cell metabolism and autophagy

(2012) Heesun Cheong et al.   NATURE BIOTECHNOLOGY

Combinatorial drug therapy for cancer in the post-genomic era

(2012) Bissan Al-Lazikani et al.   NATURE BIOTECHNOLOGY

Phase I study of terameprocol in patients with recurrent high-grade glioma

(2012) S. A. Grossman et al.   NEURO-ONCOLOGY

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

(2012) Marco Gerlinger et al.   NEW ENGLAND JOURNAL OF MEDICINE

Caspase-7 uses an exosite to promote poly(ADP ribose) polymerase 1 proteolysis

(2012) D. Boucher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nisin, an apoptogenic bacteriocin and food preservative, attenuates HNSCC tumorigenesis via CHAC1

(2012) Nam E. Joo et al.   Cancer Medicine

BAX supports the mitochondrial network, promoting bioenergetics in nonapoptotic cells

(2011) Rebecca J. Boohaker et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling

(2011) Jisun Lee et al.   BIOCHEMICAL JOURNAL

Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress

(2011) K. Zaugg et al.   GENES & DEVELOPMENT

CHK1 Inhibitors in Combination Chemotherapy: Thinking Beyond the Cell Cycle

(2011) P. Dent et al.   MOLECULAR INTERVENTIONS

Targeting cancer metabolism: a therapeutic window opens

(2011) Matthew G. Vander Heiden   NATURE REVIEWS DRUG DISCOVERY

Bnip3 as a Dual Regulator of Mitochondrial Turnover and Cell Death in the Myocardium

(2011) Åsa B. Gustafsson   PEDIATRIC CARDIOLOGY

Variations in the exome of the LNCaP prostate cancer cell line

(2011) Lien Spans et al.   PROSTATE

AMPK Is a Direct Adenylate Charge-Regulated Protein Kinase

(2011) J. S. Oakhill et al.   SCIENCE

Anticancer Targets in the Glycolytic Metabolism of Tumors: A Comprehensive Review

(2011) Paolo E. Porporato et al.   Frontiers in Pharmacology

Targeting apoptosis pathways in pancreatic cancer

(2010) Alexander Arlt et al.   CANCER LETTERS

The autophagic tumor stroma model of cancer

(2010) Stephanos Pavlides et al.   CELL CYCLE

Succinate dehydrogenase – Assembly, regulation and role in human disease

(2010) Jared Rutter et al.   MITOCHONDRION

Distant metastasis occurs late during the genetic evolution of pancreatic cancer

(2010) Shinichi Yachida et al.   NATURE

Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation

(2010) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

In search of an “autophagomometer”

(2009) David C. Rubinsztein et al.   Autophagy

TopHat: discovering splice junctions with RNA-Seq

(2009) Cole Trapnell et al.   BIOINFORMATICS

Role of BNIP3 and NIX in cell death, autophagy and mitophagy

(2009) J Zhang et al.   CELL DEATH AND DIFFERENTIATION

Superoxide is the major reactive oxygen species regulating autophagy

(2009) Y Chen et al.   CELL DEATH AND DIFFERENTIATION

The Double-Edged Sword of Autophagy Modulation in Cancer

(2009) E. White et al.   CLINICAL CANCER RESEARCH

Calpain-1 Cleaves and Activates Caspase-7

(2009) Juliette Gafni et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A CaPful of mechanisms regulating the mitochondrial permeability transition

(2009) Fabio Di Lisa et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

ATF3 transcription factor and its emerging roles in immunity and cancer

(2009) Matthew R. Thompson et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains

(2009) G. Bellot et al.   MOLECULAR AND CELLULAR BIOLOGY

BNIP3 subfamily BH3-only proteins: mitochondrial stress sensors in normal and pathological functions

(2009) G Chinnadurai et al.   ONCOGENE

Reactive oxygen species: an Achilles’ heel of melanoma?

(2008) John P Fruehauf et al.   Expert Review of Anticancer Therapy