Discovery of a Series of Acridinones as Mechanism-Based Tubulin Assembly Inhibitors with Anticancer Activity

Natural antitubulin agents: Importance of 3,4,5-trimethoxyphenyl fragment

(2015) Arvind S. Negi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis, biological evaluation and molecular modeling of 1,3,4-thiadiazol-2-amide derivatives as novel antitubulin agents

(2014) Yu-Jing Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and biological evaluation of 4-aza-2,3-dihydropyridophenanthrolines as tubulin polymerization inhibitors

(2014) Ahmed Kamal et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Paxillin inhibits HDAC6 to regulate microtubule acetylation, Golgi structure, and polarized migration

(2014) Nicholas O. Deakin et al.   JOURNAL OF CELL BIOLOGY

The Novel Microtubule-Destabilizing Drug BAL27862 Binds to the Colchicine Site of Tubulin with Distinct Effects on Microtubule Organization

(2014) Andrea E. Prota et al.   JOURNAL OF MOLECULAR BIOLOGY

A High-Content, Multiplexed Screen in Human Breast Cancer Cells Identifies Profilin-1 Inducers with Anti-Migratory Activities

(2014) Marion E. Joy et al.   PLoS One

Development of a Novel Class of Tubulin Inhibitors with Promising Anticancer Activities

(2013) Jingle Xi et al.   MOLECULAR CANCER RESEARCH

Molecular Mechanism of Action of Microtubule-Stabilizing Anticancer Agents

(2013) A. E. Prota et al.   SCIENCE

Targeting tumor cell motility as a strategy against invasion and metastasis

(2013) Alan Wells et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Strategies for the discovery and development of therapies for metastatic breast cancer

(2012) Bedrich L. Eckhardt et al.   NATURE REVIEWS DRUG DISCOVERY

An Overview of Tubulin Inhibitors That Interact with the Colchicine Binding Site

(2012) Yan Lu et al.   PHARMACEUTICAL RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Anticancer Properties of an Important Drug Lead Podophyllotoxin Can Be Efficiently Mimicked by Diverse Heterocyclic Scaffolds Accessible via One-Step Synthesis

(2011) Igor V. Magedov et al.   JOURNAL OF MEDICINAL CHEMISTRY

BNC105: A Novel Tubulin Polymerization Inhibitor That Selectively Disrupts Tumor Vasculature and Displays Single-Agent Antitumor Efficacy

(2010) G. Kremmidiotis et al.   MOLECULAR CANCER THERAPEUTICS

Microtubule-binding agents: a dynamic field of cancer therapeutics

(2010) Charles Dumontet et al.   NATURE REVIEWS DRUG DISCOVERY

Drawing the PDB: Protein−Ligand Complexes in Two Dimensions

(2010) Katrin Stierand et al.   ACS Medicinal Chemistry Letters

On and Around Microtubules: An Overview

(2009) Richard H. Wade   MOLECULAR BIOTECHNOLOGY