A High-Content, Multiplexed Screen in Human Breast Cancer Cells Identifies Profilin-1 Inducers with Anti-Migratory Activities

Profilin-1 downregulation has contrasting effects on early vs late steps of breast cancer metastasis

(2013) Z Ding et al.   ONCOGENE

Strategies for the discovery and development of therapies for metastatic breast cancer

(2012) Bedrich L. Eckhardt et al.   NATURE REVIEWS DRUG DISCOVERY

Profilin1 is required for glial cell adhesion and radial migration of cerebellar granule neurons

(2011) Jan A Kullmann et al.   EMBO REPORTS

A Simplified Synthesis of Novel Dictyostatin Analogues with In Vitro Activity against Epothilone B-Resistant Cells and Antiangiogenic Activity in Zebrafish Embryos

(2011) L. L. Vollmer et al.   MOLECULAR CANCER THERAPEUTICS

A Perspective on Cancer Cell Metastasis

(2011) C. L. Chaffer et al.   SCIENCE

A Cell-Based High-Content Screening Assay Reveals Activators and Inhibitors of Cancer Cell Invasion

(2011) M. Quintavalle et al.   Science Signaling

Cell Migration and Invasion Assays as Tools for Drug Discovery

(2011) Keren I. Hulkower et al.   Pharmaceutics

Mechanical Integration of Actin and Adhesion Dynamics in Cell Migration

(2010) Margaret L. Gardel et al.   Annual Review of Cell and Developmental Biology

Profilin1 regulates PI(3,4)P2 and lamellipodin accumulation at the leading edge thus influencing motility of MDA-MB-231 cells

(2010) Y. H. Bae et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Non-redundant roles for Profilin2 and Profilin1 during vertebrate gastrulation

(2009) Deepak K. Khadka et al.   DEVELOPMENTAL BIOLOGY

Both actin and polyproline interactions of profilin-1 are required for migration, invasion and capillary morphogenesis of vascular endothelial cells

(2009) Zhijie Ding et al.   EXPERIMENTAL CELL RESEARCH

Knockdown of ASIC1 and Epithelial Sodium Channel Subunits Inhibits Glioblastoma Whole Cell Current and Cell Migration

(2009) Niren Kapoor et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of profilin-1 expression enhances breast cancer cell motility by Ena/VASP proteins

(2009) Yong Ho Bae et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Mammalian Cardenolides in Cancer Prevention and Therapeutics

(2009) Mohammad Al-Ghoul et al.   THERAPEUTIC DRUG MONITORING

A novel circular invasion assay mimics in vivo invasive behavior of cancer cell lines and distinguishes single-cell motility in vitro

(2008) Yoonseok Kam et al.   BMC CANCER

A cell-active inhibitor of mitogen-activated protein kinase phosphatases restores paclitaxel-induced apoptosis in dexamethasone-protected cancer cells

(2008) A. Vogt et al.   MOLECULAR CANCER THERAPEUTICS