Isoflurane Exposure Induces Cell Death, Microglial Activation and Modifies the Expression of Genes Supporting Neurodevelopment and Cognitive Function in the Male Newborn Piglet Brain

Epigenetic Manipulation of Brain-derived Neurotrophic Factor Improves Memory Deficiency Induced by Neonatal Anesthesia in Rats

(2016) Jiang Wu et al.   ANESTHESIOLOGY

Neurodevelopmental outcome at 2 years of age after general anaesthesia and awake-regional anaesthesia in infancy (GAS): an international multicentre, randomised controlled trial

(2016) Andrew J Davidson et al.   LANCET

Placental, Matrilineal, and Epigenetic Mechanisms Promoting Environmentally Adaptive Development of the Mammalian Brain

(2016) Kevin D. Broad et al.   NEURAL PLASTICITY

Impact of propofol anaesthesia on cytokine expression profiles in the developing rat brain

(2015) Parichehr Kargaran et al.   EUROPEAN JOURNAL OF ANAESTHESIOLOGY

Early enriched environment induces an increased conversion of proBDNF to BDNF in the adult rat's hippocampus

(2014) Wenyu Cao et al.   BEHAVIOURAL BRAIN RESEARCH

Burst suppression-MAC and burst suppression-CP 50 as measures of cerebral effects of anaesthetics

(2014) S. Pilge et al.   BRITISH JOURNAL OF ANAESTHESIA

Npas4 Regulates Excitatory-Inhibitory Balance within Neural Circuits through Cell-Type-Specific Gene Programs

(2014) Ivo Spiegel et al.   CELL

Epigenetic Enhancement of Brain-Derived Neurotrophic Factor Signaling Pathway Improves Cognitive Impairments Induced by Isoflurane Exposure in Aged Rats

(2014) MuHuo Ji et al.   MOLECULAR NEUROBIOLOGY

Isoflurane exposure in newborn rats induces long-term cognitive dysfunction in males but not females

(2014) Bradley H. Lee et al.   NEUROPHARMACOLOGY

Mouse vision as a gateway for understanding how experience shapes neural circuits

(2014) Nicholas J. Priebe et al.   Frontiers in Neural Circuits

The Anesthetic Effects on Vasopressor Modulation of Cerebral Blood Flow in an Immature Swine Model

(2013) Benjamin Bruins et al.   ANESTHESIA AND ANALGESIA

Neither Xenon nor Fentanyl Induces Neuroapoptosis in the Newborn Pig Brain

(2013) Hemmen Sabir et al.   ANESTHESIOLOGY

Developmental Effects of Neonatal Isoflurane and Sevoflurane Exposure in Rats

(2013) Christoph N. Seubert et al.   ANESTHESIOLOGY

Selective Anesthesia-induced Neuroinflammation in Developing Mouse Brain and Cognitive Impairment

(2013) Xia Shen et al.   ANESTHESIOLOGY

Isoflurane-induced Apoptosis of Neurons and Oligodendrocytes in the Fetal Rhesus Macaque Brain

(2013) Catherine E. Creeley et al.   ANESTHESIOLOGY

Isoflurane affects the cytoskeleton but not survival, proliferation, or synaptogenic properties of rat astrocytes in vitro

(2013) D.J. Culley et al.   BRITISH JOURNAL OF ANAESTHESIA

The activity-dependent transcription factor NPAS4 regulates domain-specific inhibition

(2013) Brenda L. Bloodgood et al.   NATURE

Isoflurane postconditioning reduces ischemia-induced nuclear factor-κB activation and interleukin 1β production to provide neuroprotection in rats and mice

(2013) Hong Li et al.   NEUROBIOLOGY OF DISEASE

Coordinated Cell Type–Specific Epigenetic Remodeling in Prefrontal Cortex Begins before Birth and Continues into Early Adulthood

(2013) Hennady P. Shulha et al.   PLoS Genetics

DNA Methylation Signatures in Development and Aging of the Human Prefrontal Cortex

(2012) Shusuke Numata et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Isoflurane-induced apoptosis of oligodendrocytes in the neonatal primate brain

(2012) Ansgar M. Brambrink et al.   ANNALS OF NEUROLOGY

Isoflurane/nitrous oxide anesthesia and stress-induced procedures enhance neuroapoptosis in intrauterine growth-restricted piglets

(2012) Harald Schubert et al.   INTENSIVE CARE MEDICINE

Attention-Deficit/Hyperactivity Disorder After Early Exposure to Procedures Requiring General Anesthesia

(2012) Juraj Sprung et al.   MAYO CLINIC PROCEEDINGS

Neonatal electroencephalography shows low sensitivity to anesthesia

(2012) Kazuko Hayashi et al.   NEUROSCIENCE LETTERS

Long-term Differences in Language and Cognitive Function After Childhood Exposure to Anesthesia

(2012) C. Ing et al.   PEDIATRICS

Early Childhood Exposure to Anesthesia and Risk of Developmental and Behavioral Disorders in a Sibling Birth Cohort

(2011) Charles DiMaggio et al.   ANESTHESIA AND ANALGESIA

Academic Performance in Adolescence after Inguinal Hernia Repair in Infancy

(2011) Tom G. Hansen et al.   ANESTHESIOLOGY

Neuronal cell death in neonatal hypoxia-ischemia

(2011) Frances J. Northington et al.   ANNALS OF NEUROLOGY

Use It or Lose It? Lessons Learned from the Developing Brains of Children Who are Deaf and Use Cochlear Implants to Hear

(2011) K. A. Gordon et al.   BRAIN TOPOGRAPHY

Nociceptive stimuli enhance anesthetic-induced neuroapoptosis in the rat developing brain

(2011) Yi Shu et al.   NEUROBIOLOGY OF DISEASE

Isoflurane-induced Neuroapoptosis in the Neonatal Rhesus Macaque Brain

(2010) Ansgar M. Brambrink et al.   ANESTHESIOLOGY

Timing versus duration

(2010) Sabina Rizzi et al.   Annals of the New York Academy of Sciences

Isoflurane Anesthesia Induced Persistent, Progressive Memory Impairment, Caused a Loss of Neural Stem Cells, and Reduced Neurogenesis in Young, but Not Adult, Rodents

(2010) Changlian Zhu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Isoflurane Anesthesia Elicits Protein Pattern Changes in Rat Hippocampus

(2010) Armin Kalenka et al.   JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY

The inhalation anesthetic isoflurane increases levels of proinflammatory TNF-α, IL-6, and IL-1β

(2010) Xu Wu et al.   NEUROBIOLOGY OF AGING

Inhibition of p75 Neurotrophin Receptor Attenuates Isoflurane-mediated Neuronal Apoptosis in the Neonatal Central Nervous System

(2009) Brian P. Head et al.   ANESTHESIOLOGY

Isoflurane Differentially Affects Neurogenesis and Long-term Neurocognitive Function in 60-day-old and 7-day-old Rats

(2009) Greg Stratmann et al.   ANESTHESIOLOGY

Activation and deactivation of periventricular white matter phagocytes during postnatal mouse development

(2009) Mariya Hristova et al.   GLIA

A Retrospective Cohort Study of the Association of Anesthesia and Hernia Repair Surgery With Behavioral and Developmental Disorders in Young Children

(2009) Charles DiMaggio et al.   JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY

Towards a new developmental synthesis: adaptive developmental plasticity and human disease

(2009) Peter D Gluckman et al.   LANCET

Neuron-glia communication via EphA4/ephrin-A3 modulates LTP through glial glutamate transport

(2009) Alessandro Filosa et al.   NATURE NEUROSCIENCE

General Anesthesia Causes Long-Lasting Disturbances in the Ultrastructural Properties of Developing Synapses in Young Rats

(2009) N. Lunardi et al.   NEUROTOXICITY RESEARCH

Transcription Factors in Long-Term Memory and Synaptic Plasticity

(2009) Cristina M. Alberini   PHYSIOLOGICAL REVIEWS

Anesthesia and Cognitive Performance in Children: No Evidence for a Causal Relationship

(2009) Meike Bartels et al.   Twin Research and Human Genetics

Signaling Mechanisms Linking Neuronal Activity to Gene Expression and Plasticity of the Nervous System

(2008) Steven W. Flavell et al.   Annual Review of Neuroscience

COX-2, but not COX-1, activity is necessary for the induction of perforant path long-term potentiation and spatial learningin vivo

(2008) T. R. Cowley et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Molecular mechanisms of experience-dependent plasticity in visual cortex

(2008) D. Tropea et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES