Novel Clostridium difficile Anti-Toxin (TcdA and TcdB) Humanized Monoclonal Antibodies Demonstrate In Vitro Neutralization across a Broad Spectrum of Clinical Strains and In Vivo Potency in a Hamster Spore Challenge Model
Published 2016 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Novel Clostridium difficile Anti-Toxin (TcdA and TcdB) Humanized Monoclonal Antibodies Demonstrate In Vitro Neutralization across a Broad Spectrum of Clinical Strains and In Vivo Potency in a Hamster Spore Challenge Model
Authors
Keywords
Toxins, Clostridium difficile, Hamsters, Antibodies, Bacterial spores, Antibiotics, Monoclonal antibodies, Vancomycin
Journal
PLoS One
Volume 11, Issue 6, Pages e0157970
Publisher
Public Library of Science (PLoS)
Online
2016-06-24
DOI
10.1371/journal.pone.0157970
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- A Combination of Three Fully Human Toxin A- and Toxin B-Specific Monoclonal Antibodies Protects against Challenge with Highly Virulent Epidemic Strains of Clostridium difficile in the Hamster Model
- (2015) Natalie G. Anosova et al. Clinical and Vaccine Immunology
- Defining the Roles of TcdA and TcdB in Localized Gastrointestinal Disease, Systemic Organ Damage, and the Host Response during Clostridium difficile Infections
- (2015) Glen P. Carter et al. mBio
- A Novel Multivalent, Single-Domain Antibody Targeting TcdA and TcdB Prevents Fulminant Clostridium difficile Infection in Mice
- (2014) Zhiyong Yang et al. JOURNAL OF INFECTIOUS DISEASES
- High-Throughput Epitope Binning Assays on Label-Free Array-Based Biosensors Can Yield Exquisite Epitope Discrimination That Facilitates the Selection of Monoclonal Antibodies with Functional Activity
- (2014) Yasmina Noubia Abdiche et al. PLoS One
- Guidelines for Diagnosis, Treatment and Prevention of Clostridium difficile Infections
- (2013) Christina M Surawicz et al. AMERICAN JOURNAL OF GASTROENTEROLOGY
- A Mixture of Functionally Oligoclonal Humanized Monoclonal Antibodies That Neutralize Clostridium difficile TcdA and TcdB with High Levels ofIn VitroPotency ShowsIn VivoProtection in a Hamster Infection Model
- (2013) Nicola L. Davies et al. Clinical and Vaccine Immunology
- An overview of fecal microbiota transplantation: techniques, indications, and outcomes
- (2013) Lawrence J. Brandt et al. GASTROINTESTINAL ENDOSCOPY
- Protective Efficacy Induced by Recombinant Clostridium difficile Toxin Fragments
- (2013) Rosanna Leuzzi et al. INFECTION AND IMMUNITY
- Duodenal Infusion of Donor Feces for Recurrent Clostridium difficile
- (2013) Els van Nood et al. NEW ENGLAND JOURNAL OF MEDICINE
- Clostridium Difficile Infection in Older Adults: A Review and Update on Its Management
- (2012) Vicki R. Kee American Journal Geriatric Pharmacotherapy
- Association of Relapse of Clostridium difficile Disease with BI/NAP1/027
- (2012) J. W. Marsh et al. JOURNAL OF CLINICAL MICROBIOLOGY
- Crosstalk between Human IgG Isotypes and Murine Effector Cells
- (2012) M. B. Overdijk et al. JOURNAL OF IMMUNOLOGY
- Antibody Against TcdB, but Not TcdA, Prevents Development of Gastrointestinal and Systemic Clostridium difficile Disease
- (2012) Jennifer Steele et al. JOURNAL OF INFECTIOUS DISEASES
- Protection Against Clostridium difficile Infection With Broadly Neutralizing Antitoxin Monoclonal Antibodies
- (2012) Andre J. Marozsan et al. JOURNAL OF INFECTIOUS DISEASES
- Clostridium difficile Toxins: Mediators of Inflammation
- (2012) Aimee Shen Journal of Innate Immunity
- Clostridium difficile: Development of a novel candidate vaccine
- (2012) Ginamarie Foglia et al. VACCINE
- Monoclonal Antibodies and Toxins—A Perspective on Function and Isotype
- (2012) Siu-Kei Chow et al. Toxins
- Fecal Transplantation, Through Colonoscopy, Is Effective Therapy for Recurrent Clostridium difficile Infection
- (2011) Eero Mattila et al. GASTROENTEROLOGY
- Neutralization ofClostridium difficileToxin A with Single-domain Antibodies Targeting the Cell Receptor Binding Domain
- (2011) Greg Hussack et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Host and Pathogen Factors forClostridium difficileInfection and Colonization
- (2011) Vivian G. Loo et al. NEW ENGLAND JOURNAL OF MEDICINE
- Clostridium difficile: An Update for the Primary Care Clinician
- (2011) Alan R. Salkind SOUTHERN MEDICAL JOURNAL
- Clostridium difficile and Methicillin-Resistant Staphylococcus aureus: Emerging Concepts in Vaccine Development
- (2010) David C. Kaslow et al. Annual Review of Medicine
- Management ofClostridium difficileInfection: Thinking Inside and Outside the Box
- (2010) Dale N. Gerding et al. CLINICAL INFECTIOUS DISEASES
- The Changing Epidemiology of Clostridium difficile Infections
- (2010) J. Freeman et al. CLINICAL MICROBIOLOGY REVIEWS
- Clinical Practice Guidelines for Clostridium difficile Infection in Adults: 2010 Update by the Society for Healthcare Epidemiology of America (SHEA) and the Infectious Diseases Society of America (IDSA)
- (2010) Stuart H. Cohen et al. INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
- Four Distinct Structural Domains in Clostridium difficile Toxin B Visualized Using SAXS
- (2010) David Albesa-Jové et al. JOURNAL OF MOLECULAR BIOLOGY
- Clostridium difficile infection in Europe: a hospital-based survey
- (2010) Martijn P Bauer et al. LANCET
- Neutralization ofClostridium difficiletoxin A using antibody combinations
- (2010) Stephen J. Demarest et al. mAbs
- The role of toxin A and toxin B in Clostridium difficile infection
- (2010) Sarah A. Kuehne et al. NATURE
- Clostridium difficile infection: epidemiology, risk factors and management
- (2010) Ashwin N. Ananthakrishnan Nature Reviews Gastroenterology & Hepatology
- Treatment with Monoclonal Antibodies againstClostridium difficileToxins
- (2010) Israel Lowy et al. NEW ENGLAND JOURNAL OF MEDICINE
- Structural organization of the functional domains of Clostridium difficile toxins A and B
- (2010) R. N. Pruitt et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Variations in TcdB Activity and the Hypervirulence of Emerging Strains of Clostridium difficile
- (2010) Jordi M. Lanis et al. PLoS Pathogens
- Toxin-Specific Antibodies for the Treatment of Clostridium difficile: Current Status and Future Perspectives
- (2010) Greg Hussack et al. Toxins
- Health Care–AssociatedClostridium difficileInfection in Adults Admitted to Acute Care Hospitals in Canada: A Canadian Nosocomial Infection Surveillance Program Study
- (2009) Denise Gravel et al. CLINICAL INFECTIOUS DISEASES
- Toxin B is essential for virulence of Clostridium difficile
- (2009) Dena Lyras et al. NATURE
- Serum anti-toxin B antibody correlates with protection from recurrent Clostridium difficile infection (CDI)
- (2009) Brett A. Leav et al. VACCINE
- Expression of recombinant Clostridium difficile toxin A and B in Bacillus megaterium
- (2008) Guilin Yang et al. BMC MICROBIOLOGY
- Prospective Derivation and Validation of a Clinical Prediction Rule for Recurrent Clostridium difficile Infection
- (2008) Mary Y. Hu et al. GASTROENTEROLOGY
- What have we learned about antimicrobial use and the risks for Clostridium difficile-associated diarrhoea?
- (2008) J. M. Blondeau JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Increased Sporulation Rate of Epidemic Clostridium difficile Type 027/NAP1
- (2008) T. Akerlund et al. JOURNAL OF CLINICAL MICROBIOLOGY
- Comparative analysis of BI/NAP1/027 hypervirulent strains reveals novel toxin B-encoding gene (tcdB) sequences
- (2008) R. A. Stabler et al. JOURNAL OF MEDICAL MICROBIOLOGY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started