Ion Channels in Endothelial Responses to Fluid Shear Stress

Endothelial primary cilia inhibit atherosclerosis

(2016) Colin Dinsmore et al.   EMBO REPORTS

Measurement of shear stress-mediated intracellular calcium dynamics in human dermal lymphatic endothelial cells

(2015) M. Jafarnejad et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Shear stress mediates exocytosis of functional TRPV4 channels in endothelial cells

(2015) Sara Baratchi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Oscillatory Flow Modulates Mechanosensitive klf2a Expression through trpv4 and trpp2 during Heart Valve Development

(2015) Emilie Heckel et al.   CURRENT BIOLOGY

Selective delivery of IFN-γ to renal interstitial myofibroblasts: a novel strategy for the treatment of renal fibrosis

(2015) Fariba Poosti et al.   FASEB JOURNAL

Calcium release through P2X4 activates calmodulin to promote endolysosomal membrane fusion

(2015) Qi Cao et al.   JOURNAL OF CELL BIOLOGY

Role of epithelial Na+channels in endothelial function

(2015) Dongqing Guo et al.   JOURNAL OF CELL SCIENCE

P2Y2 and Gq/G11 control blood pressure by mediating endothelial mechanotransduction

(2015) ShengPeng Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Piezo1 regulates mechanotransductive release of ATP from human RBCs

(2015) Eyup Cinar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Shear stress modulates endothelial KLF2 through activation of P2X4

(2015) R. Sathanoori et al.   Purinergic Signalling

Chemical activation of the mechanotransduction channel Piezo1

(2015) Ruhma Syeda et al.   eLife

A Cilia Independent Role of Ift88/Polaris during Cell Migration

(2015) Christopher Boehlke et al.   PLoS One

TRPV4, TRPC1, and TRPP2 assemble to form a flow-sensitive heteromeric channel

(2014) Juan Du et al.   FASEB JOURNAL

Endothelial Cilia Are Essential for Developmental Vascular Integrity in Zebrafish

(2014) S. Kallakuri et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Piezo2 is the major transducer of mechanical forces for touch sensation in mice

(2014) Sanjeev S. Ranade et al.   NATURE

Piezo2 is required for Merkel-cell mechanotransduction

(2014) Seung-Hyun Woo et al.   NATURE

Piezo1 integration of vascular architecture with physiological force

(2014) Jing Li et al.   NATURE

Piezo1, a mechanically activated ion channel, is required for vascular development in mice

(2014) S. S. Ranade et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endothelial Cilia Mediate Low Flow Sensing during Zebrafish Vascular Development

(2014) Jacky G. Goetz et al.   Cell Reports

Polycystin Signaling Is Required for Directed Endothelial Cell Migration and Lymphatic Development

(2014) Patricia Outeda et al.   Cell Reports

Laminar shear stress upregulates endothelial Ca2+-activated K+ channels KCa2.3 and KCa3.1 via a Ca2+/calmodulin-dependent protein kinase kinase/Akt/p300 cascade

(2013) Jun Takai et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Shear stress-induced Ang II AT1 receptor activation: G-protein dependent and independent mechanisms

(2013) Valerio G. Barauna et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Critical roles of a small conductance Ca2+-activated K+ channel (SK3) in the repolarization process of atrial myocytes

(2013) Xiao-Dong Zhang et al.   CARDIOVASCULAR RESEARCH

Flow detection and calcium signalling in vascular endothelial cells

(2013) Joji Ando et al.   CARDIOVASCULAR RESEARCH

Piezo1-dependent stretch-activated channels are inhibited by Polycystin-2 in renal tubular epithelial cells

(2013) Rémi Peyronnet et al.   EMBO REPORTS

P2X4 receptors and neuropathic pain

(2013) Makoto Tsuda et al.   Frontiers in Cellular Neuroscience

Human haemodynamic frequency harmonics regulate the inflammatory phenotype of vascular endothelial cells

(2013) Ryan E. Feaver et al.   Nature Communications

IFT88 Plays a Cilia- and PCP-Independent Role in Controlling Oriented Cell Divisions during Vertebrate Embryonic Development

(2013) Antonia Borovina et al.   Cell Reports

Mutations in the mechanotransduction protein PIEZO1 are associated with hereditary xerocytosis

(2012) R. Zarychanski et al.   BLOOD

An inwardly rectifying K+ channel is required for patterning

(2012) G. R. Dahal et al.   DEVELOPMENT

Flow-Regulated Endothelial S1P Receptor-1 Signaling Sustains Vascular Development

(2012) Bongnam Jung et al.   DEVELOPMENTAL CELL

Ca2+-activated Cl- channels at a glance

(2012) J. Berg et al.   JOURNAL OF CELL SCIENCE

Membrane depolarization is the trigger for PI3K/Akt activation and leads to the generation of ROS

(2011) Shampa Chatterjee et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Inhibition of Kir2.1 (KCNJ2) by the AMP-activated protein kinase

(2011) Ioana Alesutan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Laminar shear stress modulates the activity of heterologously expressed P2X4 receptors

(2011) Sarah Kessler et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Two distinct phases of calcium signalling under flow

(2011) Bo Liu et al.   CARDIOVASCULAR RESEARCH

Cerebral Arteriogenesis is Enhanced by Pharmacological as Well as Fluid-Shear-Stress Activation of the Trpv4 Calcium Channel

(2011) W. Schierling et al.   EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY

Visualization of flow-induced ATP release and triggering of Ca2+ waves at caveolae in vascular endothelial cells

(2011) K. Yamamoto et al.   JOURNAL OF CELL SCIENCE

Effects of Disturbed Flow on Vascular Endothelium: Pathophysiological Basis and Clinical Perspectives

(2011) Jeng-Jiann Chiu et al.   PHYSIOLOGICAL REVIEWS

Functional Role of Vanilloid Transient Receptor Potential 4-Canonical Transient Receptor Potential 1 Complex in Flow-Induced Ca 2+ Influx

(2010) Xin Ma et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Mechanosensitivity of Nav1.5, a voltage-sensitive sodium channel

(2010) Arthur Beyder et al.   JOURNAL OF PHYSIOLOGY-LONDON

Pkd1-inactivation in vascular smooth muscle cells and adaptation to hypertension

(2010) Sabrine Hassane et al.   LABORATORY INVESTIGATION

Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels

(2010) B. Coste et al.   SCIENCE

TRPV4-mediated endothelial Ca2+ influx and vasodilation in response to shear stress

(2009) Suelhem A. Mendoza et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Polycystin-1 and -2 Dosage Regulates Pressure Sensing

(2009) Reza Sharif-Naeini et al.   CELL

Genetic Deficit of SK3 and IK1 Channels Disrupts the Endothelium-Derived Hyperpolarizing Factor Vasodilator Pathway and Causes Hypertension

(2009) Sebastian Brähler et al.   CIRCULATION

Ciliary Polycystin-2 Is a Mechanosensitive Calcium Channel Involved in Nitric Oxide Signaling Cascades

(2009) Wissam A. AbouAlaiwi et al.   CIRCULATION RESEARCH

Endothelial Cilia Are Fluid Shear Sensors That Regulate Calcium Signaling and Nitric Oxide Production Through Polycystin-1

(2008) Surya M. Nauli et al.   CIRCULATION

Phosphoinositides Regulate P2X4 ATP-Gated Channels through Direct Interactions

(2008) L.-P. Bernier et al.   JOURNAL OF NEUROSCIENCE