Ploidy dynamics and evolvability in fungi

Host-induced aneuploidy and phenotypic diversification in the Sudden Oak Death pathogen Phytophthora ramorum

(2016) Takao Kasuga et al.   BMC GENOMICS

Phenotypic Consequences of a Spontaneous Loss of Heterozygosity in a Common Laboratory Strain of Candida albicans

(2016) T. Ciudad et al.   GENETICS

Further support for aneuploidy tolerance in wild yeast and effects of dosage compensation on gene copy-number evolution

(2016) Audrey P Gasch et al.   eLife

Gene Essentiality Is a Quantitative Property Linked to Cellular Evolvability

(2015) Gaowen Liu et al.   CELL

A Relay Race on the Evolutionary Adaptation Spectrum

(2015) Avihu H. Yona et al.   CELL

Parasexual Ploidy Reduction Drives Population Heterogeneity Through Random and Transient Aneuploidy in Candida albicans

(2015) Meleah A. Hickman et al.   GENETICS

Polyploidy can drive rapid adaptation in yeast

(2015) Anna M. Selmecki et al.   NATURE

Cryptococcus: from environmental saprophyte to global pathogen

(2015) Robin C. May et al.   NATURE REVIEWS MICROBIOLOGY

Short- and long-term effects of chromosome mis-segregation and aneuploidy

(2015) Stefano Santaguida et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cryptococcus gattii in the Age of Whole-Genome Sequencing

(2015) W. Meyer   mBio

Polyploid Titan Cells Produce Haploid and Aneuploid Progeny To Promote Stress Adaptation

(2015) Aleeza C. Gerstein et al.   mBio

Genomic Correlates of Virulence Attenuation in the Deadly Amphibian Chytrid Fungus, Batrachochytrium dendrobatidis

(2015) Jeanine M. Refsnider et al.   G3-Genes Genomes Genetics

The Fitness Consequences of Aneuploidy Are Driven by Condition-Dependent Gene Effects

(2015) Anna B. Sunshine et al.   PLOS BIOLOGY

Dosage compensation can buffer copy-number variation in wild yeast

(2015) James Hose et al.   eLife

The evolution of drug resistance in clinical isolates of Candida albicans

(2015) Christopher B Ford et al.   eLife

Parasexual Ploidy Reduction Drives Population Heterogeneity Through Random and Transient Aneuploidy in Candida albicans

(2015) Meleah A. Hickman et al.   GENETICS

Extensive and coordinated control of allele-specific expression by both transcription and translation in Candida albicans

(2014) D. Muzzey et al.   GENOME RESEARCH

Genetic and phenotypic intra-species variation inCandida albicans

(2014) Matthew P. Hirakawa et al.   GENOME RESEARCH

Candidiasis: Predisposing Factors, Prevention, Diagnosis and Alternative Treatment

(2014) Natália Martins et al.   MYCOPATHOLOGIA

The cryptic sexual strategies of human fungal pathogens

(2014) Iuliana V. Ene et al.   NATURE REVIEWS MICROBIOLOGY

Causes and consequences of centrosome abnormalities in cancer

(2014) S. A. Godinho et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Rapid Mechanisms for Generating Genome Diversity: Whole Ploidy Shifts, Aneuploidy, and Loss of Heterozygosity

(2014) R. J. Bennett et al.   Cold Spring Harbor Perspectives in Medicine

Y MAP : a pipeline for visualization of copy number variation and loss of heterozygosity in eukaryotic pathogens

(2014) Darren A Abbey et al.   Genome Medicine

A Tetraploid Intermediate Precedes Aneuploid Formation in Yeasts Exposed to Fluconazole

(2014) Benjamin D. Harrison et al.   PLOS BIOLOGY

Azole Heteroresistance in Cryptococcus neoformans: Emergence of Resistant Clones with Chromosomal Disomy in the Mouse Brain during Fluconazole Treatment

(2013) Edward Sionov et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Chromosome 5 Monosomy of Candida albicans Controls Susceptibility to Various Toxic Agents, Including Major Antifungals

(2013) Feng Yang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The ‘obligate diploid’ Candida albicans forms mating-competent haploids

(2013) Meleah A. Hickman et al.   NATURE

Passage through the mammalian gut triggers a phenotypic switch that promotes Candida albicans commensalism

(2013) Kalyan Pande et al.   NATURE GENETICS

Complex history of the amphibian-killing chytrid fungus revealed with genome resequencing data

(2013) Erica Bree Rosenblum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aneuploidy underlies a multicellular phenotypic switch

(2013) Z. Tan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ploidy variation as an adaptive mechanism in human pathogenic fungi

(2013) Carl A. Morrow et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Comparative Genomics of Serial Isolates of Cryptococcus neoformans Reveals Gene Associated With Carbon Utilization and Virulence

(2013) Kate L. Ormerod et al.   G3-Genes Genomes Genetics

Breakage-fusion-bridge Cycles and Large Insertions Contribute to the Rapid Evolution of Accessory Chromosomes in a Fungal Pathogen

(2013) Daniel Croll et al.   PLoS Genetics

Balancing Stability and Flexibility within the Genome of the Pathogen Cryptococcus neoformans

(2013) Kate L. Ormerod et al.   PLoS Pathogens

Two unlike cousins:Candida albicansandC. glabratainfection strategies

(2012) Sascha Brunke et al.   CELLULAR MICROBIOLOGY

Normal Adaptation of Candida albicans to the Murine Gastrointestinal Tract Requires Efg1p-Dependent Regulation of Metabolic and Host Defense Genes

(2012) Jessica V. Pierce et al.   EUKARYOTIC CELL

Life History Shapes Trait Heredity by Accumulation of Loss-of-Function Alleles in Yeast

(2012) E. Zorgo et al.   MOLECULAR BIOLOGY AND EVOLUTION

Novel insights into genome plasticity in Eukaryotes: mosaic aneuploidy inLeishmania

(2012) Yvon Sterkers et al.   MOLECULAR MICROBIOLOGY

Hsp90 stress potentiates rapid cellular adaptation through induction of aneuploidy

(2012) Guangbo Chen et al.   NATURE

Emerging fungal threats to animal, plant and ecosystem health

(2012) Matthew C. Fisher et al.   NATURE

Chromosomal duplication is a transient evolutionary solution to stress

(2012) A. H. Yona et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Does stress induce (para)sex? Implications for Candida albicans evolution

(2012) Judith Berman et al.   TRENDS IN GENETICS

Adaptive mechanisms in pathogens: universal aneuploidy in Leishmania

(2012) An Mannaert et al.   TRENDS IN PARASITOLOGY

Variation in chromosome copy number influences the virulence of Cryptococcus neoformans and occurs in isolates from AIDS patients

(2011) Guanggan Hu et al.   BMC GENOMICS

Outcrossing, mitotic recombination, and life-history trade-offs shape genome evolution inSaccharomyces cerevisiae

(2011) Paul M. Magwene et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aneuploidy Drives Genomic Instability in Yeast

(2011) J. M. Sheltzer et al.   SCIENCE

High-Resolution SNP/CGH Microarrays Reveal the Accumulation of Loss of Heterozygosity in Commonly Used Candida albicans Strains

(2011) Darren Abbey et al.   G3-Genes Genomes Genetics

Heteroresistance of Cryptococcus gattii to Fluconazole

(2010) A. Varma et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

CandidaBloodstream Infections: Comparison of Species Distributions and Antifungal Resistance Patterns in Community-Onset and Nosocomial Isolates in the SENTRY Antimicrobial Surveillance Program, 2008-2009

(2010) Michael A. Pfaller et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Fungal Sex and Pathogenesis

(2010) G. Butler   CLINICAL MICROBIOLOGY REVIEWS

Dr Jekyll and Mr Hyde: role of aneuploidy in cellular adaptation and cancer

(2010) Norman Pavelka et al.   CURRENT OPINION IN CELL BIOLOGY

Loss of Heterozygosity at an Unlinked Genomic Locus Is Responsible for the Phenotype of a Candida albicans sap4 Δ sap5 Δ sap6 Δ Mutant

(2010) Nico Dunkel et al.   EUKARYOTIC CELL

Genomic Plasticity of the Human Fungal Pathogen Candida albicans

(2010) Anna Selmecki et al.   EUKARYOTIC CELL

Imaging morphogenesis of Candida albicans during infection in a live animal

(2010) Soumya Mitra et al.   JOURNAL OF BIOMEDICAL OPTICS

Aneuploidy confers quantitative proteome changes and phenotypic variation in budding yeast

(2010) Norman Pavelka et al.   NATURE

Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium

(2010) Li-Jun Ma et al.   NATURE

Evolution of the sex-Related Locus and Genomic Features Shared in Microsporidia and Fungi

(2010) Soo Chan Lee et al.   PLoS One

Virulence Attenuation of Candida albicans Genetic Variants Isolated from a Patient with a Recurrent Bloodstream Infection

(2010) Paula Sampaio et al.   PLoS One

Incipient Balancing Selection through Adaptive Loss of Aquaporins in Natural Saccharomyces cerevisiae Populations

(2010) Jessica L. Will et al.   PLoS Genetics

Cryptococcal Cell Morphology Affects Host Cell Interactions and Pathogenicity

(2010) Laura H. Okagaki et al.   PLoS Pathogens

Fungal Cell Gigantism during Mammalian Infection

(2010) Oscar Zaragoza et al.   PLoS Pathogens

Estimation of the current global burden of cryptococcal meningitis among persons living with HIV/AIDS

(2009) Benjamin J Park et al.   AIDS

An A643T Mutation in the Transcription Factor Upc2p Causes Constitutive ERG11 Upregulation and Increased Fluconazole Resistance in Candida albicans

(2009) C. J. Heilmann et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Heteroresistance to Fluconazole in Cryptococcus neoformans Is Intrinsic and Associated with Virulence

(2009) E. Sionov et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mechanistic Plasticity of Sexual Reproduction and Meiosis in the Candida Pathogenic Species Complex

(2009) Jennifer L. Reedy et al.   CURRENT BIOLOGY

Aneuploid Chromosomes Are Highly Unstable during DNA Transformation ofCandida albicans

(2009) Kelly Bouchonville et al.   EUKARYOTIC CELL

A Pathogenesis Assay UsingSaccharomycescerevisiaeandCaenorhabditiselegansReveals Novel Roles for Yeast AP-1, Yap1, and Host Dual Oxidase BLI-3 in Fungal Pathogenesis

(2009) Charu Jain et al.   EUKARYOTIC CELL

Efficient and rapid identification ofCandida albicansallelic status using SNP-RFLP

(2009) Anja Forche et al.   FEMS YEAST RESEARCH

Adaptive prediction of environmental changes by microorganisms

(2009) Amir Mitchell et al.   NATURE

Acquisition of Aneuploidy Provides Increased Fitness during the Evolution of Antifungal Drug Resistance

(2009) Anna M. Selmecki et al.   PLoS Genetics

Gain of Function Mutations in CgPDR1 of Candida glabrata Not Only Mediate Antifungal Resistance but Also Enhance Virulence

(2009) Sélène Ferrari et al.   PLoS Pathogens

Aneuploidy Underlies Rapid Adaptive Evolution of Yeast Cells Deprived of a Conserved Cytokinesis Motor

(2008) Giulia Rancati et al.   CELL

Functional Mapping of theCandida albicansEfg1 Regulator

(2008) Christine S. Noffz et al.   EUKARYOTIC CELL

Phenotypic diversity of Flo protein family-mediated adhesion inSaccharomyces cerevisiae

(2008) Sebastiaan E. Van Mulders et al.   FEMS YEAST RESEARCH

Aneuploidy: Cells Losing Their Balance

(2008) Eduardo M. Torres et al.   GENETICS

An isochromosome confers drug resistance in vivo by amplification of two genes, ERG11 and TAC1

(2008) Anna Selmecki et al.   MOLECULAR MICROBIOLOGY

The Parasexual Cycle in Candida albicans Provides an Alternative Pathway to Meiosis for the Formation of Recombinant Strains

(2008) Anja Forche et al.   PLOS BIOLOGY

Mating is rare within as well as between clades of the human pathogen Candida albicans

(2007) Marie-Elisabeth Bougnoux et al.   FUNGAL GENETICS AND BIOLOGY