Thermosensitive Transient Receptor Potential (TRP) Channel Agonists and Their Role in Mechanical, Thermal and Nociceptive Sensations as Assessed Using Animal Models

Activation of transient receptor potential vanilloid 2-expressing primary afferents stimulates synaptic transmission in the deep dorsal horn of the rat spinal cord and elicits mechanical hyperalgesia

(2014) Hugues Petitjean et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Citral: A monoterpene with prophylactic and therapeutic anti-nociceptive effects in experimental models of acute and chronic pain

(2014) Catarine M. Nishijima et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Eugenol and carvacrol excite first- and second-order trigeminal neurons and enhance their heat-evoked responses

(2014) A.H. Klein et al.   NEUROSCIENCE

Acute Heat-Evoked Temperature Sensation Is Impaired but Not Abolished in Mice Lacking TRPV1 and TRPV3 Channels

(2014) Irène Marics et al.   PLoS One

TRPA1 channels mediate acute neurogenic inflammation and pain produced by bacterial endotoxins

(2014) Victor Meseguer et al.   Nature Communications

Ion Channel Profile of TRPM8 Cold Receptors Reveals a Role of TASK-3 Potassium Channels in Thermosensation

(2014) Cruz Morenilla-Palao et al.   Cell Reports

The Antinociceptive and Antihyperalgesic Effects of Topical Propofol on Dorsal Horn Neurons in the Rat

(2013) Kenichi Takechi et al.   ANESTHESIA AND ANALGESIA

TRP Channels and Pain

(2013) David Julius   Annual Review of Cell and Developmental Biology

Targeting TRP channels for pain relief

(2013) Jill-Desiree Brederson et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Signal transduction via TRPM3 channels in pancreatic β-cells

(2013) Gerald Thiel et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

The Cellular Code for Mammalian Thermosensation

(2013) L. A. Pogorzala et al.   JOURNAL OF NEUROSCIENCE

A Sensory-Labeled Line for Cold: TRPM8-Expressing Sensory Neurons Define the Cellular Basis for Cold, Cold Pain, and Cooling-Mediated Analgesia

(2013) W. M. Knowlton et al.   JOURNAL OF NEUROSCIENCE

Sex differences in anti-allodynic, anti-hyperalgesic and anti-edema effects of Δ9-tetrahydrocannabinol in the rat

(2013) Rebecca M. Craft et al.   PAIN

Eugenol and carvacrol induce temporally desensitizing patterns of oral irritation and enhance innocuous warmth and noxious heat sensation on the tongue

(2013) Amanda H. Klein et al.   PAIN

Prostaglandin Metabolite Induces Inhibition of TRPA1 and Channel-Dependent Nociception

(2012) Yingqi Weng et al.   Molecular Pain

Topical hindpaw application of L-menthol decreases responsiveness to heat with biphasic effects on cold sensitivity of rat lumbar dorsal horn neurons

(2012) A.H. Klein et al.   NEUROSCIENCE

TRPA1 Contributes to the Acute Inflammatory Response and Mediates Carrageenan-Induced Paw Edema in the Mouse

(2012) Lauri J. Moilanen et al.   Scientific Reports

Activation of steroid-sensitive TRPM3 channels potentiates glutamatergic transmission at cerebellar Purkinje neurons from developing rats

(2011) Paula A. Zamudio-Bulcock et al.   JOURNAL OF NEUROCHEMISTRY

A tingling sanshool derivative excites primary sensory neurons and elicits nocifensive behavior in rats

(2011) Amanda H. Klein et al.   JOURNAL OF NEUROPHYSIOLOGY

TRP Vanilloid 2 Knock-Out Mice Are Susceptible to Perinatal Lethality But Display Normal Thermal and Mechanical Nociception

(2011) U. Park et al.   JOURNAL OF NEUROSCIENCE

TRPA1 contributes to specific mechanically activated currents and sensory neuron mechanical hypersensitivity

(2011) Stuart M. Brierley et al.   JOURNAL OF PHYSIOLOGY-LONDON

TRPV3 and TRPV4 Ion Channels are Not Major Contributors to Mouse Heat Sensation

(2011) Susan M Huang et al.   Molecular Pain

TRPM3 Is a Nociceptor Channel Involved in the Detection of Noxious Heat

(2011) Joris Vriens et al.   NEURON

Transient receptor potential cation channel, subfamily C, member 5 (TRPC5) is a cold-transducer in the peripheral nervous system

(2011) K. Zimmermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Topical application of l-menthol induces heat analgesia, mechanical allodynia, and a biphasic effect on cold sensitivity in rats

(2010) Amanda H. Klein et al.   BEHAVIOURAL BRAIN RESEARCH

A role for transient receptor potential vanilloid 4 in tonicity-induced neurogenic inflammation

(2010) N Vergnolle et al.   BRITISH JOURNAL OF PHARMACOLOGY

Pungency of TRPV1 agonists is directly correlated with kinetics of receptor activation and lipophilicity

(2010) Daniel Ursu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Farnesyl Pyrophosphate Is a Novel Pain-producing Molecule via Specific Activation of TRPV3

(2010) Sangsu Bang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRPM3 is expressed in sphingosine-responsive myelinating oligodendrocytes

(2010) Anja Hoffmann et al.   JOURNAL OF NEUROCHEMISTRY

TRPA1 Contributes to Cold Hypersensitivity

(2010) D. del Camino et al.   JOURNAL OF NEUROSCIENCE

Behavioral evidence of thermal hyperalgesia and mechanical allodynia induced by intradermal cinnamaldehyde in rats

(2010) Merab G. Tsagareli et al.   NEUROSCIENCE LETTERS

TRPM8, but not TRPA1, is required for neural and behavioral responses to acute noxious cold temperatures and cold-mimetics in vivo

(2010) Wendy M. Knowlton et al.   PAIN

The necessity of animal models in pain research

(2010) Jeffrey S. Mogil et al.   PAIN

TRPA1 Mediates Mechanical Currents in the Plasma Membrane of Mouse Sensory Neurons

(2010) Daniel Vilceanu et al.   PLoS One

Excitation of cutaneous C nociceptors by intraplantar administration of anandamide

(2009) Carl Potenzieri et al.   BRAIN RESEARCH

Roles of transient receptor potential channels in pain

(2009) Cheryl L. Stucky et al.   BRAIN RESEARCH REVIEWS

TRPA1 Modulates Mechanotransduction in Cutaneous Sensory Neurons

(2009) K. Y. Kwan et al.   JOURNAL OF NEUROSCIENCE

Pharmacological Blockade of TRPA1 Inhibits Mechanical Firing in Nociceptors

(2009) Patrick C Kerstein et al.   Molecular Pain

Animal models of pain: progress and challenges

(2009) Jeffrey S. Mogil   NATURE REVIEWS NEUROSCIENCE

Mustard oil enhances spinal neuronal responses to noxious heat but not cooling

(2009) Carolyn M. Sawyer et al.   NEUROSCIENCE LETTERS

Molecular mechanism for local anesthetic action of eugenol in the rat trigeminal system

(2009) Chul-Kyu Park et al.   PAIN

The involvement of the transient receptor potential A1 (TRPA1) in the maintenance of mechanical and cold hyperalgesia in persistent inflammation

(2009) Diogo Santos M. da Costa et al.   PAIN

TRPA1 acts as a cold sensor in vitro and in vivo

(2009) Y. Karashima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of TRPV1 receptors in pain evoked by noxious thermal and chemical stimuli

(2009) William D. Willis   EXPERIMENTAL BRAIN RESEARCH

Regulation of Calcium-Permeable TRPV2 Channel by Insulin in Pancreatic  -Cells

(2008) E. Hisanaga et al.   DIABETES

TRPV2 Is Activated by Cannabidiol and Mediates CGRP Release in Cultured Rat Dorsal Root Ganglion Neurons

(2008) N. Qin et al.   JOURNAL OF NEUROSCIENCE

TRPV1 Unlike TRPV2 Is Restricted to a Subset of Mechanically Insensitive Cutaneous Nociceptors Responding to Heat

(2008) Jeffrey J. Lawson et al.   JOURNAL OF PAIN

HC-030031, a TRPA1 Selective Antagonist, Attenuates Inflammatory- and Neuropathy-Induced Mechanical Hypersensitivity

(2008) Samer R Eid et al.   Molecular Pain

Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic β cells

(2008) Thomas F.J. Wagner et al.   NATURE CELL BIOLOGY

Transient receptor potential channels: targeting pain at the source

(2008) Ardem Patapoutian et al.   NATURE REVIEWS DRUG DISCOVERY

Lysophosphatidylcholine induces neuropathic pain through an action of autotaxin to generate lysophosphatidic acid

(2008) M. Inoue et al.   NEUROSCIENCE

Principle components analysis of pain thresholds to thermal, electrical, and mechanical stimuli suggests a predominant common source of variance

(2008) Till J. Neddermeyer et al.   PAIN

Citral Sensing by TRANSient Receptor Potential Channels in Dorsal Root Ganglion Neurons

(2008) Stephanie C. Stotz et al.   PLoS One

Monoterpenoid agonists of TRPV3

(2007) A K Vogt-Eisele et al.   BRITISH JOURNAL OF PHARMACOLOGY

Effects of TRPA1 Agonists Mustard Oil and Cinnamaldehyde on Lumbar Spinal Wide-Dynamic Range Neuronal Responses to Innocuous and Noxious Cutaneous Stimuli in Rats

(2007) Austin W. Merrill et al.   JOURNAL OF NEUROPHYSIOLOGY

The role of TRPV1 receptors in the antinociceptive effect of anandamide at spinal level

(2007) Gyöngyi Horvath et al.   PAIN