Glycans in Medicinal Chemistry: An Underexploited Resource

A guide into glycosciences: How chemistry, biochemistry and biology cooperate to crack the sugar code

(2015) Dolores Solís et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

O-GlcNAc and neurodegeneration: biochemical mechanisms and potential roles in Alzheimer's disease and beyond

(2014) Scott A. Yuzwa et al.   CHEMICAL SOCIETY REVIEWS

Chemical Biology Approaches to Designing Defined Carbohydrate Vaccines

(2014) Chakkumkal Anish et al.   CHEMISTRY & BIOLOGY

Recent strategies targeting HIV glycans in vaccine design

(2014) Satoru Horiya et al.   Nature Chemical Biology

Development of a minimal saponin vaccine adjuvant based on QS-21

(2014) Alberto Fernández-Tejada et al.   Nature Chemistry

NMR and molecular recognition. The application of ligand-based NMR methods to monitor molecular interactions

(2014) Luca Unione et al.   MedChemComm

Chaperone therapy update: Fabry disease, GM1-gangliosidosis and Gaucher disease

(2013) Yoshiyuki Suzuki   BRAIN & DEVELOPMENT

The development of synthetic antitumour vaccines from mucin glycopeptide antigens

(2013) Nikola Gaidzik et al.   CHEMICAL SOCIETY REVIEWS

Glycotherapy: New Advances Inspire a Reemergence of Glycans in Medicine

(2013) Jason E. Hudak et al.   CHEMISTRY & BIOLOGY

A Vision for Vaccines Built from Fully Synthetic Tumor-Associated Antigens: From the Laboratory to the Clinic

(2013) Rebecca M. Wilson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemical Synthesis of Highly Congested gp120 V1V2 N-Glycopeptide Antigens for Potential HIV-1-Directed Vaccines

(2013) Baptiste Aussedat et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthetic glycopeptides reveal the glycan specificity of HIV-neutralizing antibodies

(2013) Mohammed N Amin et al.   Nature Chemical Biology

Therapeutic potential of deglycosylated antibodies

(2013) M. Crispin   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Erythropoietin Derived by Chemical Synthesis

(2013) P. Wang et al.   SCIENCE

Realizing the promise of chemical glycobiology

(2013) Lai-Xi Wang et al.   Chemical Science

Isotype and glycoform selection for antibody therapeutics

(2012) Roy Jefferis   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Carbohydrate microarrays

(2012) Sungjin Park et al.   CHEMICAL SOCIETY REVIEWS

Chemical approaches to study O-GlcNAcylation

(2012) Partha S. Banerjee et al.   CHEMICAL SOCIETY REVIEWS

Synthetic heparin

(2012) Robert J Linhardt et al.   CURRENT OPINION IN PHARMACOLOGY

Recent Development in Carbohydrate Based Anticancer Vaccines

(2012) Zhaojun Yin et al.   JOURNAL OF CARBOHYDRATE CHEMISTRY

Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation

(2012) Scott A Yuzwa et al.   Nature Chemical Biology

Glycan Microarrays for Decoding the Glycome

(2011) Cory D. Rillahan et al.   Annual Review of Biochemistry

Cross Talk Between O-GlcNAcylation and Phosphorylation: Roles in Signaling, Transcription, and Chronic Disease

(2011) Gerald W. Hart et al.   Annual Review of Biochemistry

Carbohydrate-Protein Interactions: A 3D View by NMR

(2011) Virginia Roldós et al.   CHEMBIOCHEM

Natural and synthetic saponin adjuvant QS-21 for vaccines against cancer

(2011) Govind Ragupathi et al.   Expert Review of Vaccines

Advances in the assessment and control of the effector functions of therapeutic antibodies

(2011) Xu-Rong Jiang et al.   NATURE REVIEWS DRUG DISCOVERY

Carbohydrate chemistry in drug discovery

(2011) M. Carmen Galan et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Immune recognition of tumor-associated mucin MUC1 is achieved by a fully synthetic aberrantly glycosylated MUC1 tripartite vaccine

(2011) V. Lakshminarayanan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Recognition of β-O-GlcNAc Glycopeptides by a Lectin-Like Receptor: Binding Modulation by the Underlying Ser or Thr Amino Acids

(2010) Francisco Corzana et al.   CHEMBIOCHEM

Discovery and design of carbohydrate-based therapeutics

(2010) Laura Cipolla et al.   Expert Opinion on Drug Discovery

Carbohydrate-Based Bioactive Compounds for Medicinal Chemistry Applications

(2010) L. Cipolla et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Immunotherapy for cancer: synthetic carbohydrate-based vaccines

(2009) Therese Buskas et al.   CHEMICAL COMMUNICATIONS

Recent advances in carbohydrate-based vaccines

(2009) Marie-Lyn Hecht et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Carbohydrates: A Frontier in Medicinal Chemistry

(2009) Pierre Stallforth et al.   JOURNAL OF MEDICINAL CHEMISTRY

Emerging methods for the production of homogeneous human glycoproteins

(2009) Jamie R Rich et al.   Nature Chemical Biology

Glycosylation as a strategy to improve antibody-based therapeutics

(2009) Roy Jefferis   NATURE REVIEWS DRUG DISCOVERY

From carbohydrate leads to glycomimetic drugs

(2009) Beat Ernst et al.   NATURE REVIEWS DRUG DISCOVERY

Glycoprotein Synthesis: An Update

(2008) David P. Gamblin et al.   CHEMICAL REVIEWS

Effects of glycosylation on the stability of protein pharmaceuticals

(2008) Ricardo J. Solá et al.   JOURNAL OF PHARMACEUTICAL SCIENCES