Pyrimidine Triazole Thioether Derivatives as Toll-Like Receptor 5 (TLR5)/Flagellin Complex Inhibitors

Structure–Activity Relationship Studies of Functionally Selective Kappa Opioid Receptor Agonists that Modulate ERK 1/2 Phosphorylation While Preserving G Protein Over βArrestin2 Signaling Bias

(2015) Kimberly M. Lovell et al.   ACS Chemical Neuroscience

Microbially Driven TLR5-Dependent Signaling Governs Distal Malignant Progression through Tumor-Promoting Inflammation

(2015) Melanie R. Rutkowski et al.   CANCER CELL

Toll-like receptor 5 in obesity: The role of gut microbiota and adipose tissue inflammation

(2015) Satu Pekkala et al.   Obesity

Specific activation of the TLR1-TLR2 heterodimer by small-molecule agonists

(2015) K. Cheng et al.   Science Advances

Ligation of TLR5 Promotes Myeloid Cell Infiltration and Differentiation into Mature Osteoclasts in Rheumatoid Arthritis and Experimental Arthritis

(2014) Seung-jae Kim et al.   JOURNAL OF IMMUNOLOGY

MAP1S Controls Breast Cancer Cell TLR5 Signaling Pathway and Promotes TLR5 Signaling-based Tumor Suppression

(2014) Ming Shi et al.   PLoS One

A Flagellin-Derived Toll-Like Receptor 5 Agonist Stimulates Cytotoxic Lymphocyte-Mediated Tumor Immunity

(2014) Nicholas D. Leigh et al.   PLoS One

Role of TLR5 and Flagella in Bacillus Intraocular Infection

(2014) Salai Madhumathi Parkunan et al.   PLoS One

Prevention and cure of rotavirus infection via TLR5/NLRC4-mediated production of IL-22 and IL-18

(2014) B. Zhang et al.   SCIENCE

Angiogenesis in Rheumatoid Arthritis Is Fostered Directly by Toll-like Receptor 5 Ligation and Indirectly Through Interleukin-17 Induction

(2013) Seung-jae Kim et al.   ARTHRITIS AND RHEUMATISM

Functional TLR5 Genetic Variants Affect Human Colorectal Cancer Survival

(2013) S. N. Klimosch et al.   CANCER RESEARCH

Targeting Toll-like receptors with small molecule agents

(2013) Xiaohui Wang et al.   CHEMICAL SOCIETY REVIEWS

The Yin and Yang of Toll-like receptors in cancer

(2013) J-P Pradere et al.   ONCOGENE

Fine-Tuning Multiprotein Complexes Using Small Molecules

(2012) Andrea D. Thompson et al.   ACS Chemical Biology

Discovery of Small-Molecule Inhibitors of the TLR1/TLR2 Complex

(2012) Kui Cheng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structural Biology and Drug Discovery of Difficult Targets: The Limits of Ligandability

(2012) Sachin Surade et al.   CHEMISTRY & BIOLOGY

Structural Basis of TLR5-Flagellin Recognition and Signaling

(2012) S.-i. Yoon et al.   SCIENCE

Toll-like receptor 5 forms asymmetric dimers in the absence of flagellin

(2011) Kaifeng Zhou et al.   JOURNAL OF STRUCTURAL BIOLOGY

Application of a novel in silico high-throughput screen to identify selective inhibitors for protein–protein interactions

(2010) Catherine Joce et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Metabolic Syndrome and Altered Gut Microbiota in Mice Lacking Toll-Like Receptor 5

(2010) M. Vijay-Kumar et al.   SCIENCE

A Peptide Antagonist of the TLR4-MD2 Interaction

(2009) Peter F. Slivka et al.   CHEMBIOCHEM

Synthesis and evaluation of pyrido-thieno-pyrimidines as potent and selective Cdc7 kinase inhibitors

(2008) Chunlin Zhao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of some new 1,2,4-triazoles, their Mannich and Schiff bases and evaluation of their antimicrobial activities

(2008) Hacer Bayrak et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

An Agonist of Toll-Like Receptor 5 Has Radioprotective Activity in Mouse and Primate Models

(2008) L. G. Burdelya et al.   SCIENCE