Recent Developments in the Trifluoromethylation of Alkynes

Oxidative Trifluoromethylation and Trifluoromethylthiolation Reactions Using (Trifluoromethyl)trimethylsilane as a Nucleophilic CF3 Source

(2014) Lingling Chu et al.   ACCOUNTS OF CHEMICAL RESEARCH

Practical Methods for the Synthesis of Trifluoromethylated Alkynes: Oxidative Trifluoromethylation of Copper Acetylides and Alkynes

(2014) Cédric Tresse et al.   ADVANCED SYNTHESIS & CATALYSIS

Copper-Catalyzed One-Pot Trifluoromethylation/Aryl Migration/Carbonyl Formation with Homopropargylic Alcohols

(2014) Pin Gao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Iron-Catalyzed 1,2-Addition of Perfluoroalkyl Iodides to Alkynes and Alkenes

(2014) Tao Xu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A new strategy to construct a CC–CF3 subunit via CuBr-catalyzed domino reaction of homopropargyl amines: an efficient synthesis of trifluoromethyl containing building blocks 4-trifluoromethyl-2,3-dihydro-pyrroliums

(2014) Guang-Cun Ge et al.   CHEMICAL COMMUNICATIONS

Copper-catalyzed endo-type trifluoromethylarylation of alkynes

(2014) Jun Xu et al.   CHEMICAL COMMUNICATIONS

Electrophilic Trifluoromethylation by Use of Hypervalent Iodine Reagents

(2014) Julie Charpentier et al.   CHEMICAL REVIEWS

Addition of CF3 across unsaturated moieties: a powerful functionalization tool

(2014) Estíbaliz Merino et al.   CHEMICAL SOCIETY REVIEWS

Recent Progress in Direct Introduction of Fluorinated Groups on Alkenes and Alkynes by means of CH Bond Functionalization

(2014) Tatiana Besset et al.   CHEMISTRY-A EUROPEAN JOURNAL

Dual Catalysis with Copper and Rhenium for Trifluoromethylation of Propargylic Alcohols: Efficient Synthesis of α-Trifluoromethylated Enones

(2014) Hiromichi Egami et al.   CHEMISTRY-A EUROPEAN JOURNAL

Recent Advances in Trifluoromethylation Reactions with Electrophilic Trifluoromethylating Reagents

(2014) Sebastián Barata-Vallejo et al.   CHEMISTRY-A EUROPEAN JOURNAL

Copper-Catalyzed Intramolecular Carbotrifluoromethylation of Alkynes for the Construction of Trifluoromethylated Heterocycles

(2014) Yanan Wang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Copper-Catalyzed Difunctionalization of Activated Alkynes by Radical Oxidation-Tandem Cyclization/Dearomatization to Synthesize 3-Trifluoromethyl Spiro[4.5]trienones

(2014) Hui-Liang Hua et al.   CHEMISTRY-A EUROPEAN JOURNAL

Stereoselective Synthesis of α-Trifluoromethyl Enones by AuI/CuI-Co-Catalyzed Tandem 1,3-Acyloxy Migration/Trifluoromethylation Reaction of Propargyl Acetates

(2014) Yun-Long Ji et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Copper-mediated trifluoromethylation of propargyl acetates leading to trifluoromethyl-allenes

(2014) Yun-Long Ji et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Direct Access to α-Trifluoromethyl Enones via Efficient Copper-Catalyzed Trifluoromethylation of Meyer–Schuster Rearrangement

(2014) Ya-Ping Xiong et al.   ORGANIC LETTERS

Copper-Catalyzed Direct Trifluoromethylation of Propiolates: Construction of Trifluoromethylated Coumarins

(2014) Yuewen Li et al.   ORGANIC LETTERS

Direct Synthesis of α-Trifluoromethyl Ketone from (Hetero)arylacetylene: Design, Intermediate Trapping, and Mechanistic Investigations

(2014) Arun Maji et al.   ORGANIC LETTERS

Iodotrifluoromethylation of Alkenes and Alkynes with Sodium Trifluoromethanesulfinate and Iodine Pentoxide

(2014) Zhaojia Hang et al.   ORGANIC LETTERS

Metal-Free Photocatalytic Radical Trifluoromethylation Utilizing Methylene Blue and Visible Light Irradiation

(2014) Spencer P. Pitre et al.   ACS Catalysis

Copper-catalyzed tandem trifluoromethylation/cyclization of internal alkynes

(2014) Yun-Long Ji et al.   Organic Chemistry Frontiers

Direct Trifluoromethylation of the CH Bond

(2013) Hui Liu et al.   ADVANCED SYNTHESIS & CATALYSIS

Controlled Trifluoromethylation Reactions of Alkynes through Visible-Light Photoredox Catalysis

(2013) Naeem Iqbal et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Silver-Catalyzed Hydrotrifluoromethylation of Unactivated Alkenes with CF3SiMe3

(2013) Xinyue Wu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Copper-catalyzed nucleophilic trifluoromethylation of propargylic halides

(2013) Yoshihiro Miyake et al.   CHEMICAL COMMUNICATIONS

Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)

(2013) Jiang Wang et al.   CHEMICAL REVIEWS

Direct Synthesis of a Trifluoromethyl Copper Reagent from Trifluoromethyl Ketones: Application to Trifluoromethylation

(2013) Hiroki Serizawa et al.   CHEMISTRY-A EUROPEAN JOURNAL

Copper-Mediated Trifluoromethylation of Terminal Alkynes byS-(Trifluoromethyl)diarylsulfonium Salt

(2013) Xiaoping Wang et al.   CHINESE JOURNAL OF CHEMISTRY

Copper-Mediated Radical Trifluoromethylation of Unsaturated Potassium Organotrifluoroborates

(2013) Marc Presset et al.   JOURNAL OF ORGANIC CHEMISTRY

Catalytic Hydrotrifluoromethylation of Unactivated Alkenes

(2013) Satoshi Mizuta et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Recent Advances in Transition-Metal-Catalyzed Trifluoromethylation and Related Transformations

(2013) Guosheng Liu et al.   SYNTHESIS-STUTTGART

Copper-mediated trifluoromethylation of propiolic acids: facile synthesis of α-trifluoromethyl ketones

(2013) Zhengbiao He et al.   Chemical Science

Tamed Arene and Heteroarene Trifluoromethylation

(2012) Tatiana Besset et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A “Renaissance” in Radical Trifluoromethylation

(2012) Armido Studer   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recent Developments on the Trifluoromethylation of (Hetero)Arenes

(2012) Xiao-Feng Wu et al.   Chemistry-An Asian Journal

Copper-Catalyzed Oxidative Trifluoromethylation of Terminal Alkynes and Aryl Boronic Acids Using (Trifluoromethyl)trimethylsilane

(2012) Xueliang Jiang et al.   JOURNAL OF ORGANIC CHEMISTRY

Trifluoromethylation of Propargylic Halides and Trifluoroacetates Using (Ph3P)3Cu(CF3) Reagent

(2012) Tony S. N. Zhao et al.   ORGANIC LETTERS

Electrophilic Trifluoromethylation by Copper-Catalyzed Addition of CF3-Transfer Reagents to Alkenes and Alkynes

(2012) Pär G. Janson et al.   ORGANIC LETTERS

Hydrophobically Assisted Separation-Friendly Mitsunobu Reaction

(2012) Xin-Shan Ye et al.   SYNLETT

Mild copper-catalyzed trifluoromethylation of terminal alkynes using an electrophilic trifluoromethylating reagent

(2012) Zhiqiang Weng et al.   TETRAHEDRON

Copper-catalyzed trifluoromethylation of terminal alkynes using Umemoto’s reagent

(2012) Dong-Fen Luo et al.   TETRAHEDRON LETTERS

Synthesis of trifluoromethylated acetylenes via copper-catalyzed trifluoromethylation of alkynyltrifluoroborates

(2012) Huidong Zheng et al.   TETRAHEDRON LETTERS

Oxytrifluoromethylation of multiple bonds using copper catalyst under mild conditions

(2012) Hiromichi Egami et al.   TETRAHEDRON LETTERS

Copper-Catalyzed Trifluoromethylation of Unactivated Olefins

(2011) Andrew T. Parsons et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Simple, Stable, and Easily Accessible Well-Defined CuCF3 Aromatic Trifluoromethylating Agents

(2011) Olesya A. Tomashenko et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

How easy are the syntheses of allenes?

(2011) Shichao Yu et al.   CHEMICAL COMMUNICATIONS

Aromatic Trifluoromethylation with Metal Complexes

(2011) Olesya A. Tomashenko et al.   CHEMICAL REVIEWS

An Improved Copper-Mediated Oxidative Trifluoromethylation of Terminal Alkynes

(2011) Ke Zhang et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Copper-Catalyzed Trifluoromethylation of Terminal Alkenes through Allylic C–H Bond Activation

(2011) Jun Xu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Copper-Catalyzed C(sp3)–C(sp3) Bond Formation Using a Hypervalent Iodine Reagent: An Efficient Allylic Trifluoromethylation

(2011) Xi Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalysis for fluorination and trifluoromethylation

(2011) Takeru Furuya et al.   NATURE

Synthesis of α-CN and α-CF3N-Heterocycles through Tandem Nucleophilic Additions

(2011) Junbin Han et al.   ORGANIC LETTERS

Ruthenium-Catalyzed Regio- and Stereoselective Addition of Carboxylic Acids to Aryl and Trifluoromethyl Group Substituted Unsymmetrical Internal Alkynes

(2011) Motoi Kawatsura et al.   ORGANIC LETTERS

Combination Catalysis in Enantioselective Trifluoromethylation

(2010) Yan Zheng et al.   ADVANCED SYNTHESIS & CATALYSIS

Copper-Mediated Aerobic Oxidative Trifluoromethylation of Terminal Alkynes with Me3SiCF3

(2010) Lingling Chu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Organometallic Fluorine Chemistry of Palladium and Rhodium: Studies toward Aromatic Fluorination

(2009) Vladimir V. Grushin   ACCOUNTS OF CHEMICAL RESEARCH

New preparation and synthetic reactions of 3,3,3-trifluoropropynyllithium, -borate and -stannane: facile synthesis of trifluoromethylated allenes, arylacetylenes and enynes

(2009) Masaki Shimizu et al.   Future Medicinal Chemistry

An Efficient Protocol for the Stereoselective Construction of Multisubstituted Fluorine-Containing Alkenes. A Palladium-Catalyzed Bisstannylation of Fluorinated Internal Alkynes

(2009) Tsutomu Konno et al.   JOURNAL OF ORGANIC CHEMISTRY

Regio- and stereo-specific preparation of (E)-1-aryl-3,3,3-trifluoro-1-iodo-propenes and their palladium-catalyzed reaction with terminal alkynes

(2008) Xing-Guo Zhang et al.   JOURNAL OF FLUORINE CHEMISTRY

Fluorine in medicinal chemistry

(2007) Sophie Purser et al.   CHEMICAL SOCIETY REVIEWS