Practical Methods for the Synthesis of Trifluoromethylated Alkynes: Oxidative Trifluoromethylation of Copper Acetylides and Alkynes

Identification of Fluorinases fromStreptomycessp MA37,Norcardia brasiliensis, andActinoplanessp N902-109 by Genome Mining

(2014) Hai Deng et al.   CHEMBIOCHEM

Convenient and Practical Alkynylation of Heteronucleophiles with Copper Acetylides

(2014) Gwilherm Evano et al.   SYNTHESIS-STUTTGART

Copper(I)-Catalyzed Coupling Cyclization of Methyl Perfluoroalk-2-ynoates with 2-Aminobenzonitriles: Synthesis of 2-Perfluoroalkylated Quinolines

(2013) Jing Han et al.   ADVANCED SYNTHESIS & CATALYSIS

Direct Trifluoromethylation of the CH Bond

(2013) Hui Liu et al.   ADVANCED SYNTHESIS & CATALYSIS

Synthesis and Application of β-Substituted Pauson-Khand Adducts: Trifluoromethyl as a Removable Steering Group

(2013) Nuria Aiguabella et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Controlled Trifluoromethylation Reactions of Alkynes through Visible-Light Photoredox Catalysis

(2013) Naeem Iqbal et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Introduction of Fluorine and Fluorine-Containing Functional Groups

(2013) Theresa Liang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Computational characterization of a mechanism for the copper-catalyzed aerobic oxidative trifluoromethylation of terminal alkynes

(2013) Jesús Jover et al.   CHEMICAL COMMUNICATIONS

Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)

(2013) Jiang Wang et al.   CHEMICAL REVIEWS

19F NMR: a valuable tool for studying biological events

(2013) Han Chen et al.   CHEMICAL SOCIETY REVIEWS

Direct Synthesis of a Trifluoromethyl Copper Reagent from Trifluoromethyl Ketones: Application to Trifluoromethylation

(2013) Hiroki Serizawa et al.   CHEMISTRY-A EUROPEAN JOURNAL

Copper-Mediated Trifluoromethylation of Terminal Alkynes byS-(Trifluoromethyl)diarylsulfonium Salt

(2013) Xiaoping Wang et al.   CHINESE JOURNAL OF CHEMISTRY

Regiocontrolled Hydroarylation of (Trifluoromethyl)acetylenes in Superacids: Synthesis of CF3-Substituted 1,1-Diarylethenes

(2013) Haider M. H. Alkhafaji et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Trifluoromethylation of Aryl and Heteroaryl Halides with Fluoroform-Derived CuCF3: Scope, Limitations, and Mechanistic Features

(2013) Anton Lishchynskyi et al.   JOURNAL OF ORGANIC CHEMISTRY

Stereospecific Asymmetric N-Heterocyclic Carbene (NHC)-Catalyzed Redox Synthesis of Trifluoromethyl Dihydropyranones and Mechanistic Insights

(2013) Alyn T. Davies et al.   JOURNAL OF ORGANIC CHEMISTRY

Expanding the oxidative chemistry of organocopper reagents: facile oxidative cross-coupling of copper acetylides with arylboronic acids

(2013) Florian Verna et al.   MONATSHEFTE FUR CHEMIE

Unprecedented Synthesis of Alkynylphosphine-boranes through Room-Temperature Oxidative Alkynylation

(2013) Kévin Jouvin et al.   ORGANIC LETTERS

Recent Advances in Transition-Metal-Catalyzed Trifluoromethylation and Related Transformations

(2013) Guosheng Liu et al.   SYNTHESIS-STUTTGART

Tamed Arene and Heteroarene Trifluoromethylation

(2012) Tatiana Besset et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

3-Phenyl-5-isothiazole carboxamides with potent mGluR1 antagonist activity

(2012) Matthew J. Fisher et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Recent Developments on the Trifluoromethylation of (Hetero)Arenes

(2012) Xiao-Feng Wu et al.   Chemistry-An Asian Journal

Fluorine local environment: from screening to drug design

(2012) Anna Vulpetti et al.   DRUG DISCOVERY TODAY

Progress in Copper-Mediated Formation of Trifluoromethylated Arenes

(2012) Tianfei Liu et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

A novel synthesis of fluorine-containing cyclopentenones via Pauson–Khand reaction

(2012) Tsutomu Konno et al.   JOURNAL OF FLUORINE CHEMISTRY

Copper-Catalyzed Oxidative Trifluoromethylation of Terminal Alkynes and Aryl Boronic Acids Using (Trifluoromethyl)trimethylsilane

(2012) Xueliang Jiang et al.   JOURNAL OF ORGANIC CHEMISTRY

Copper-Mediated Trifluoromethylation of α-Diazo Esters with TMSCF3: The Important Role of Water as a Promoter

(2012) Mingyou Hu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Oxidative Alkynylation of Imines with Alkynylcopper Reagents: A Straightforward and Practical Entry to Ynimines

(2012) Gwilherm Evano et al.   SYNTHESIS-STUTTGART

Facile conversion of CF3-containing propargylic alcohol derivatives via the corresponding allenes

(2012) Takashi Yamazaki et al.   TETRAHEDRON

Mild copper-catalyzed trifluoromethylation of terminal alkynes using an electrophilic trifluoromethylating reagent

(2012) Zhiqiang Weng et al.   TETRAHEDRON

Copper-catalyzed trifluoromethylation of terminal alkynes using Umemoto’s reagent

(2012) Dong-Fen Luo et al.   TETRAHEDRON LETTERS

Synthesis of trifluoromethylated acetylenes via copper-catalyzed trifluoromethylation of alkynyltrifluoroborates

(2012) Huidong Zheng et al.   TETRAHEDRON LETTERS

Simple, Stable, and Easily Accessible Well-Defined CuCF3 Aromatic Trifluoromethylating Agents

(2011) Olesya A. Tomashenko et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Broadly Applicable Copper Reagent for Trifluoromethylations and Perfluoroalkylations of Aryl Iodides and Bromides

(2011) Hiroyuki Morimoto et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Copper-Catalyzed Aerobic Oxidative CH Functionalizations: Trends and Mechanistic Insights

(2011) Alison E. Wendlandt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bond Formations between Two Nucleophiles: Transition Metal Catalyzed Oxidative Cross-Coupling Reactions

(2011) Chao Liu et al.   CHEMICAL REVIEWS

Aromatic Trifluoromethylation with Metal Complexes

(2011) Olesya A. Tomashenko et al.   CHEMICAL REVIEWS

An Improved Copper-Mediated Oxidative Trifluoromethylation of Terminal Alkynes

(2011) Ke Zhang et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Scope and regioselectivity of the 1,3-dipolar cycloaddition of azides with methyl 2-perfluoroalkynoates for an easy, metal-free route to perfluoroalkylated 1,2,3-triazoles

(2011) Jiamei Wei et al.   JOURNAL OF FLUORINE CHEMISTRY

Application of Mitsunobu Reagents to Redox Isomerization of CF3-Containing Propargylic Alcohols to (E)-α,β-Enones

(2011) Yohsuke Watanabe et al.   JOURNAL OF ORGANIC CHEMISTRY

Direct Cupration of Fluoroform

(2011) Alessandro Zanardi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ruthenium-Catalyzed Regio- and Stereoselective Addition of Carboxylic Acids to Aryl and Trifluoromethyl Group Substituted Unsymmetrical Internal Alkynes

(2011) Motoi Kawatsura et al.   ORGANIC LETTERS

Ruthenium-Catalyzed Regioselective [2 + 2 + 2] Cyclotrimerization of Trifluoromethyl Group Substituted Internal Alkynes

(2011) Motoi Kawatsura et al.   ORGANIC LETTERS

Preparation of (E)-1-aryl-3,3,3-trifluoro-1,2-di(trimethylsilyl)-1-propenes via stereoselective bissilylation of trifluoromethyl aryl acetylenes and electrophilic substitution of its TMS groups

(2011) Toshimasa Katagiri et al.   TETRAHEDRON

Click-alkynylation of N- and P-nucleophiles by oxidative cross-coupling with alkynylcopper reagents: a general synthesis of ynamides and alkynylphosphonates

(2011) Kévin Jouvin et al.   Chemical Science

Asymmetric Construction of Stereogenic Carbon Centers Featuring a Trifluoromethyl Group from Prochiral Trifluoromethylated Substrates

(2010) Jing Nie et al.   CHEMICAL REVIEWS

Copper-Mediated Aerobic Oxidative Trifluoromethylation of Terminal Alkynes with Me3SiCF3

(2010) Lingling Chu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rhodium-catalyzed [2+2+2] cycloaddition of various fluorine-containing alkynes—novel synthesis of multi-substituted fluoroalkylated aromatic compounds

(2010) Tsutomu Konno et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Regioselectivity in Intermolecular Pauson-Khand Reactions of Dissymmetric Fluorinated Alkynes

(2010) Jean-Claude Kizirian et al.   ORGANIC LETTERS

An Efficient Protocol for the Stereoselective Construction of Multisubstituted Fluorine-Containing Alkenes. A Palladium-Catalyzed Bisstannylation of Fluorinated Internal Alkynes

(2009) Tsutomu Konno et al.   JOURNAL OF ORGANIC CHEMISTRY

Remarkable access to fluoroalkylated trisubstituted alkenes via highly stereoselective cobalt-catalyzed hydrosilylation reaction of fluoroalkylated alkynes

(2009) Tsutomu Konno et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Facile conversion of 4,4,4-trifluorobut-2-yn-1-ols to 4,4,4-trifluorobut-2-en-1-ones

(2009) Takashi Yamazaki et al.   TETRAHEDRON

Heteronuclear19F−1H Statistical Total Correlation Spectroscopy as a Tool in Drug Metabolism:  Study of Flucloxacillin Biotransformation

(2008) Hector C. Keun et al.   ANALYTICAL CHEMISTRY

The Many Roles for Fluorine in Medicinal Chemistry

(2008) William K. Hagmann   JOURNAL OF MEDICINAL CHEMISTRY

Copper-Catalyzed Aerobic Oxidative Amidation of Terminal Alkynes:  Efficient Synthesis of Ynamides

(2008) Tetsuya Hamada et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fluorination in Medicinal Chemistry: Methods, Strategies, and Recent Developments

(2008) Kenneth L. Kirk   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Fluorine in medicinal chemistry

(2007) Sophie Purser et al.   CHEMICAL SOCIETY REVIEWS