Nrf2 Is an Attractive Therapeutic Target for Retinal Diseases

The Keap1-Nrf2-ARE Pathway As a Potential Preventive and Therapeutic Target: An Update

(2016) Meng-Chen Lu et al.   MEDICINAL RESEARCH REVIEWS

Sulforaphane and Other Nutrigenomic Nrf2 Activators: Can the Clinician’s Expectation Be Matched by the Reality?

(2016) Christine A. Houghton et al.   Oxidative Medicine and Cellular Longevity

Dissecting molecular cross-talk between Nrf2 and NF-κB response pathways

(2015) Joanna D. Wardyn et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Peptide and small molecule inhibitors of the Keap1–Nrf2 protein–protein interaction

(2015) Geoff Wells   BIOCHEMICAL SOCIETY TRANSACTIONS

Novel Nrf2 activators from microbial transformation products inhibit blood-retinal barrier permeability in rabbits

(2015) Yasuhiro Nakagami et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cytoprotective Effects of a Novel Nrf2 Activator, RS9, in Rhodopsin Pro347Leu Rabbits

(2015) Yasuhiro Nakagami et al.   CURRENT EYE RESEARCH

Dimethyl Fumarate: A Review in Relapsing-Remitting MS

(2015) Emma D. Deeks   DRUGS

Effect of Omega-3 Fatty Acids, Lutein/Zeaxanthin, or Other Nutrient Supplementation on Cognitive Function

(2015) Emily Y. Chew et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Nanocarriers for treatment of ocular neovascularization in the back of the eye: new vehicles for ophthalmic drug delivery

(2015) Hsin-Hui Shen et al.   Nanomedicine

Discovery of direct inhibitors of Keap1–Nrf2 protein–protein interaction as potential therapeutic and preventive agents

(2015) Dhulfiqar Ali Abed et al.   Acta Pharmaceutica Sinica B

Mechanisms Contributing to Adverse Cardiovascular Events in Patients with Type 2 Diabetes Mellitus and Stage 4 Chronic Kidney Disease Treated with Bardoxolone Methyl

(2014) Melanie P. Chin et al.   AMERICAN JOURNAL OF NEPHROLOGY

New strategies to inhibit KEAP1 and the Cul3-based E3 ubiquitin ligases

(2014) Peter Canning et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Toxicological and Pharmacokinetic Properties of QPI-1007, a Chemically Modified Synthetic siRNA Targeting Caspase 2 mRNA, Following Intravitreal Injection

(2014) Elisabeth C.R. Solano et al.   Nucleic Acid Therapeutics

Damage of photoreceptor-derived cells in culture induced by light emitting diode-derived blue light

(2014) Yoshiki Kuse et al.   Scientific Reports

Discovery of a small-molecule inhibitor and cellular probe of Keap1–Nrf2 protein–protein interaction

(2013) Longqin Hu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

NRF2 plays a protective role in diabetic retinopathy in mice

(2013) Zhenhua Xu et al.   DIABETOLOGIA

Critical role of Nrf2 in oxidative stress-induced retinal ganglion cell death

(2013) Noriko Himori et al.   JOURNAL OF NEUROCHEMISTRY

Synthetic oleanane triterpenoids: magic bullets or not?

(2013) Hanna E. Abboud   KIDNEY INTERNATIONAL

Targeting the transcription factor Nrf2 to ameliorate oxidative stress and inflammation in chronic kidney disease

(2013) Stacey Ruiz et al.   KIDNEY INTERNATIONAL

Bardoxolone Methyl in Type 2 Diabetes and Stage 4 Chronic Kidney Disease

(2013) Dick de Zeeuw et al.   NEW ENGLAND JOURNAL OF MEDICINE

Toward clinical application of the Keap1–Nrf2 pathway

(2013) Takafumi Suzuki et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Therapeutic stratagems for vascular degenerative disorders of the posterior eye

(2012) Gaurav K. Jain et al.   DRUG DISCOVERY TODAY

Validation of the multiple sensor mechanism of the Keap1-Nrf2 system

(2012) Kai Takaya et al.   FREE RADICAL BIOLOGY AND MEDICINE

How does the macula protect itself from oxidative stress?

(2012) James T. Handa   MOLECULAR ASPECTS OF MEDICINE

Consequences of oxidative stress in age-related macular degeneration

(2012) Stuart G. Jarrett et al.   MOLECULAR ASPECTS OF MEDICINE

Ultraviolet Phototoxicity to the Retina

(2011) Randolph D Glickman   Eye & Contact Lens-Science and Clinical Practice

Nrf2 has a protective role against neuronal and capillary degeneration in retinal ischemia–reperfusion injury

(2011) Yanhong Wei et al.   FREE RADICAL BIOLOGY AND MEDICINE

Bardoxolone Methyl and Kidney Function in CKD with Type 2 Diabetes

(2011) Pablo E. Pergola et al.   NEW ENGLAND JOURNAL OF MEDICINE

Age-Related Retinopathy in NRF2-Deficient Mice

(2011) Zhenyang Zhao et al.   PLoS One

New Concept in Nutrition for the Maintenance of the Aging Eye Redox Regulation and Therapeutic Treatment of Cataract Disease; Synergism of Natural Antioxidant Imidazole-Containing Amino Acid–Based Compounds, Chaperone, and Glutathione Boosting Agents: A Systemic Perspective on Aging and Longevity Emerged From Studies in Humans

(2010) Mark A Babizhayev   AMERICAN JOURNAL OF THERAPEUTICS

Discovery of the Negative Regulator of Nrf2, Keap1: A Historical Overview

(2010) Ken Itoh et al.   ANTIOXIDANTS & REDOX SIGNALING

Clinical Trial of Lutein in Patients With Retinitis Pigmentosa Receiving Vitamin A

(2010)   ARCHIVES OF OPHTHALMOLOGY

Biodegradable Intraocular Therapies for Retinal Disorders

(2010) Noriyuki Kuno et al.   DRUGS & AGING

Role of Nrf2 in retinal vascular development and the vaso-obliterative phase of oxygen-induced retinopathy

(2010) Koichi Uno et al.   EXPERIMENTAL EYE RESEARCH

Nrf2 is a critical modulator of the innate immune response in a model of uveitis

(2009) Norihiro Nagai et al.   FREE RADICAL BIOLOGY AND MEDICINE

NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer

(2009) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

Cigarette smoking, oxidative stress, the anti-oxidant response through Nrf2 signaling, and Age-related Macular Degeneration

(2009) Marisol Cano et al.   VISION RESEARCH

Down-Regulated NF-E2–Related Factor 2 in Pulmonary Macrophages of Aged Smokers and Patients with Chronic Obstructive Pulmonary Disease

(2008) Masaru Suzuki et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Mechanisms involved in A2E oxidation

(2008) So Ra Kim et al.   EXPERIMENTAL EYE RESEARCH

Oxidative damage–induced inflammation initiates age-related macular degeneration

(2008) Joe G Hollyfield et al.   NATURE MEDICINE

Targeting Nrf2 with the triterpenoid CDDO- imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice

(2008) T. E. Sussan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA