Article
Agriculture, Dairy & Animal Science
Suresh Neethirajan
Summary: Emotions and affective states recognition in farm animals is an underexplored research domain, but the use of biometric sensors and artificial intelligence methods offer the potential to improve animal welfare standards. Currently, there are no scientifically validated methods for assessing farm animal emotions, and traditional monitoring methods have limitations. Biometric sensor data and AI technology can unobtrusively monitor farm animals, but their potential for quantifying affective states and applications are yet to be realized.
Review
Cell Biology
Simone Lista, Raul Gonzalez-Dominguez, Susana Lopez-Ortiz, Alvaro Gonzalez-Dominguez, Hector Menendez, Juan Martin-Hernandez, Alejandro Lucia, Enzo Emanuele, Diego Centonze, Bruno P. Imbimbo, Viviana Triaca, Luana Lionetto, Maurizio Simmaco, Miroslava Cuperlovic-Culf, Jericha Mill, Lingjun Li, Mark Mapstone, Alejandro Santos-Lozano, Robert Nistico
Summary: Alzheimer's disease (AD) is determined by various pathophysiological mechanisms starting 10-25 years before the onset of clinical symptoms. Metabolomics, a rapidly developing discipline, can detect and quantify hundreds/thousands of perturbed metabolites, reproducing the fluctuations of multiple networks affected by a disease. Metabolomics can help identify potential biomarkers and elucidate the pathophysiological mechanisms of AD.
AGEING RESEARCH REVIEWS
(2023)
Review
Food Science & Technology
Antonio Castro Marin, Donato Colangelo, Milena Lambri, Claudio Riponi, Fabio Chinnici
Summary: Chitosan, a natural polymer recently approved as a wine additive, shows multifaceted functions in winemaking including antimicrobial, chelating, clarifying, and antioxidant activities. Further research is needed to fully understand its specific effects in wines and explore strategies to enhance its efficacy.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Review
Biochemistry & Molecular Biology
Yi-Jen Hsueh, Yen-Ning Chen, Yu-Ting Tsao, Chao-Min Cheng, Wei-Chi Wu, Hung-Chi Chen
Summary: This article summarizes and provides updates on the research and treatment methods of ocular degenerative diseases related to oxidative stress. The article reviews the oxidative damage that occurs in different areas of the eye and introduces the antioxidant mechanisms present in the eye as well as the ocular diseases that occur as a result of antioxidant imbalances and relevant biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Fatima Zahra Kamal, Radu Lefter, Hassna Jaber, Ioana-Miruna Balmus, Alin Ciobica, Alin-Constantin Iordache
Summary: Ischemic strokes occur due to arterial blockage, leading to interrupted blood supply to the brain and potential damage or death of brain cells. Oxidative stress is an essential mechanism in ischemic stroke, and the assessment of oxidative stress biomarkers can aid in diagnosing the severity and guiding neuroprotective therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Pauline Chazelas, Clara Steichen, Frederic Favreau, Patrick Trouillas, Patrick Hannaert, Raphael Thuillier, Sebastien Giraud, Thierry Hauet, Jerome Guillard
Summary: Oxidative stress plays a crucial role in ischemia reperfusion injury, requiring a comprehensive approach using both chemical and biological tools. New research models, such as stem cell-derived organoids, bridge the gap between in vitro and in vivo studies, providing a deeper understanding of cellular interactions and pathway changes. Additional research paradigms, including molecular modeling and integrative systemic models, offer insights into the dynamic interactions between pathways, aiding in the formulation of integrated predictions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Angelique Blangy-Letheule, Amandine Vergnaud, Thomas Dupas, Bertrand Rozec, Benjamin Lauzier, Aurelia A. Leroux
Summary: Sepsis is a life-threatening disease caused by an uncontrolled immune response to infection. Due to a lack of predictive biomarkers and pertinent models, early diagnosis and effective treatment are challenging. Experimental models, mostly conducted on mice, have been used to understand the pathophysiology of sepsis and identify potential biomarkers or targets. However, results from these models are difficult to translate to humans. Horses, which naturally develop sepsis, may offer a promising spontaneous model for sepsis research with implications for both human and veterinary medicine.
Article
Psychiatry
Dariusz Juchnowicz, Michal Dzikowski, Joanna Rog, Napoleon Waszkiewicz, Anna Zalewska, Mateusz Maciejczyk, Hanna Karakula-Juchnowicz
Summary: This study found differences in serum levels of oxidative biomarkers between schizophrenia patients and healthy individuals. The pro/antioxidant status could be considered a predictor of schizophrenia and is a factor that affects the severity of patients' symptoms.
FRONTIERS IN PSYCHIATRY
(2021)
Review
Oncology
Ihsan Ullah, Le Yang, Feng-Ting Yin, Ye Sun, Xing-Hua Li, Jing Li, Xi-Jun Wang
Summary: Colorectal cancer is a prevalent and deadly disease worldwide, with its exact molecular mechanisms still unknown. The application of omics technologies in CRC research has significantly advanced, screening biomarkers unbiasedly to better understand the disease. Multi-omics studies could shed light on the discovery of novel biomarkers for CRC prognosis, diagnosis, and treatments.
Review
Physiology
Wenlong Hao, Minghao Li, Qingmin Cai, Shiying Wu, Xiangyao Li, Quanyu He, Yongbin Hu
Summary: This review discusses the KEAP1/NRF2 signaling mechanisms and recent advances in understanding the role of NRF2 in primary fibrotic lesions. It also explores the therapeutic potential of antioxidant substances and drugs and summarizes the prospects of NRF2 in fibrosis treatment.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Clinical Neurology
Julia M. Hagen, Arjen L. Sutterland, Tessa Liefers, Frederike Schirmbeck, Danny M. Cohn, Anja Lok, Hanno L. Tan, Aeilko H. Zwinderman, Lieuwe de Haan
Summary: The study showed evidence of partial mediation by skin autofluorescence in the association between affective disorders and all-cause and natural-cause mortality, although attenuated by health factors. The largest mediation by SAF was observed for major depression, which remained significant even after adjustments for sociodemographic and health factors, indicating oxidative stress as a possible determinant of premature death.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Environmental Sciences
Viviane Amaral Porto, Edmilson Rodrigues da Rocha Junior, Jeferson Santana Ursulino, Ricardo Silva Porto, Marciliano da Silva, Lazaro Wender Oliveira de Jesus, Jerusa Maria de Oliveira, Alessandre Carmo Crispim, Josue Carinhanha Caldas Santos, Thiago Mendonca de Aquino
Summary: Metabolomics is an innovative approach used in medical, toxicological, and biological sciences, and its relation to the environment and toxicological research is extensive. The continuous release of xenobiotics into the environment by substances like drugs and pesticides harms organisms and their habitats. Zebrafish, particularly, has characteristics that make it a versatile and straightforward option for toxicity assays and metabolomics profiling. NMR-based metabolomics, combined with statistical analysis, can help researchers discover and validate biomarkers for accurate diagnosis. This review focuses on studies that use zebrafish as a model for (eco)toxicological assays and utilize NMR-based metabolomics analysis to assess the biochemical profile and suggest potential biological markers.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Zoology
Zhu Li, Yuan-Xiang Zhu, Li-Jun Gu, Ying Cheng
Summary: This article summarizes several animal models used in ASD research, discussing their applications and challenges.
ZOOLOGICAL RESEARCH
(2021)
Review
Cell Biology
Soraia C. Abreu, Miqueias Lopes-Pacheco, Daniel J. Weiss, Patricia R. M. Rocco
Summary: Extracellular vesicles (EVs) are potential therapies for various diseases, released by different cell types with molecules that can promote cell repair and reduce tissue damage. These vesicles have shown therapeutic potential for lung diseases and research continues to explore their efficacy in clinical practice.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Agricultural Engineering
Adrieli Sachett, Matheus Gallas-Lopes, Radharani Benvenutti, Matheus Marcon, Gean Pablo S. Aguiar, Ana Paula Herrmann, J. Vladimir Oliveira, Anna M. Siebel, Angelo Piato
Summary: Curcumin has been shown to have various beneficial properties, but its low bioavailability limits its therapeutic potential. Micronization can enhance the bioavailability by reducing particle size. In this study, micronized curcumin exhibited superior antioxidant effects both in vitro and in vivo compared to regular curcumin. However, it was unable to fully block the behavioral effects induced by chronic stress.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Review
Chemistry, Multidisciplinary
Sorin Nicolae Peiu, Radu Florin Popa, Fawzi Akad, Iustina S. Cretu-Silivestru, Bogdan Mircea Mihai, Anatolie Visnevschi, Lorina Vudu, Bogdan Tamba, Teodor Oboroceanu, Daniel Timofte, Veronica Mocanu
Summary: This study provides an overview of the effects of perivascular adipose tissue (PVAT) and ghrelin on atherosclerosis, highlighting the need for further research on their impact in metabolic disorders.
APPLIED SCIENCES-BASEL
(2022)
Article
Psychology, Multidisciplinary
Violeta Enea, Octav Sorin Candel, Simona Alexandra Zancu, Alexandra Maftei, Livia Birladeanu, Daniel Timofte
Summary: This study investigated the relationship between death obsession, religiosity, and fear of COVID-19 among patients with type 2 diabetes. The results revealed a positive association between death obsession and fear of COVID-19, and individuals with higher levels of religiosity experienced greater levels of fear. The overall level of religiosity did not moderate the relationship between death obsession and fear of COVID-19, but only the preoccupation with God dimension of religiosity had a moderating effect.
OMEGA-JOURNAL OF DEATH AND DYING
(2022)
Article
Medicine, General & Internal
Camelia Tamas, Clara Larisa Ibanescu, Caterina Lorenzi, Audrey Clebant, T. Popa, Madalina Maxim, Loana Tamas, D. Vintila, D. Timofte, B. M. Ciuntu, Angela Tecuceanu
Summary: This study aimed to describe the importance of hyaluronic acid in the treatment of partial thickness burns and summarize the therapeutic methods and outcomes at different stages. The results showed that the use of hyaluronic acid can reduce healing time, control pain, and improve the quality of newly formed tissue, leading to good functional and aesthetic results for burn patients.
MEDICAL-SURGICAL JOURNAL-REVISTA MEDICO-CHIRURGICALA
(2022)
Article
Neurosciences
Ovidiu-Dumitru Ilie, Raluca Duta, Roxana Jijie, Ilinca-Bianca Nita, Mircea Nicoara, Caterina Faggio, Romeo Dobrin, Ioannis Mavroudis, Alin Ciobica, Bogdan Doroftei
Summary: The study showed that ROT disrupted social behavior, VPA promoted a specific behavior typology, and different treatment groups exhibited varying levels of aggressive behavior. The PROBIO group exhibited significant improvement compared to other groups, showing different patterns of behavior in response to the treatments administered.
Article
Biochemistry & Molecular Biology
Ovidiu-Dumitru Ilie, Raluca Duta, Ioana-Miruna Balmus, Alexandra Savuca, Adriana Petrovici, Ilinca-Bianca Nita, Lucian-Mihai Antoci, Roxana Jijie, Cosmin-Teodor Mihai, Alin Ciobica, Mircea Nicoara, Roxana Popescu, Romeo Dobrin, Carmen Solcan, Anca Trifan, Carol Stanciu, Bogdan Doroftei
Summary: Parkinson's disease (PD) is a neurodegenerative disorder that is currently being extensively researched. This study aimed to understand the effects of rotenone (ROT) on homeostasis and the potential neuroprotective role of valproic acid (VPA), antiparkinsonian agents (levodopa and carbidopa - LEV+CARB), and a mixture of lactobacillus and bifidobacterium species (PROBIO). The results showed that VPA, LEV/CARB, and PROBIO can alleviate the neurotoxicity caused by ROT and restore optimal internal parameters in zebrafish.
Review
Neurosciences
Alexandrina S. Curpan, Ioana-Miruna Balmus, Romeo P. Dobrin, Alin Ciobica, Gabriela E. Chele, Dragos Lucian Gorgan, Alexandra Bolos
Summary: Neurodevelopmental disorders are complex diseases that require early developmental stage zebrafish models for research. Zebrafish models show behavioral characteristics related to autism spectrum disorders and schizophrenia, but there are also limitations in terms of model species.
Review
Biochemistry & Molecular Biology
Ilinca-Bianca Nita, Ovidiu-Dumitru Ilie, Alin Ciobica, Luminita-Diana Hritcu, Irina Dobrin, Bogdan Doroftei, Romeo Dobrin
Summary: Schizophrenia is a severe brain disorder with potential involvement of gut microflora. Recent research suggests that specific lactic acid bacteria strains, combined with vitamin D and selenium, can maintain the integrity of gut flora and prevent adverse effects. However, antipsychotic medications may have negative effects on gut flora, highlighting the need for further investigation. Additionally, studying the impact of different controlled substances on microbial communities is of interest.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Imane Lakkab, Abdelmoughite Ouakil, Hanane El Hajaji, Nadya Lachkar, Radu Lefter, Alin Ciobica, Brahim El Bali, Romeo Dobrin, Luminita Diana Hritcu, Mohammed Lachkar
Summary: This study validated the positive correlation between the high antioxidant activity of carob seed peels and the improvement of negative symptoms of schizophrenia. It also confirmed the association between oxidative stress and schizophrenia. In addition, carob exhibited antibacterial effects.
Article
Nutrition & Dietetics
Radu Petru Soroceanu, Daniel Vasile Timofte, Madalina Maxim, Razvan Liviu Platon, Vlad Vlasceanu, Bogdan Mihnea Ciuntu, Alin Constantin Pinzariu, Andreea Clim, Andreea Soroceanu, Ioana Silistraru, Doina Azoicai
Summary: The aim of this study is to investigate the safety and short-term results of bariatric procedures such as laparoscopic sleeve gastrectomy, Roux-en-Y gastric bypass, laparoscopic gastric plication, and intragastric balloon in the treatment of obesity. The results showed that these procedures are safe and effective methods of weight loss and improvement of comorbidities and metabolic parameters.
Review
Biology
Alexandru Florinel Oancea, Raul Alexandru Jigoranu, Paula Cristina Morariu, Radu-Stefan Miftode, Bogdan Andrei Trandabat, Diana Elena Iov, Elena Cojocaru, Irina Iuliana Costache, Livia Genoveva Baroi, Daniel Vasile Timofte, Daniela Maria Tanase, Mariana Floria
Summary: Atrial fibrillation and chronic coronary syndrome have a strong dual relationship, with atrial fibrillation potentially accelerating atherosclerosis and increasing myocardial oxygen consumption, leading to a mismatch between supply and demand and promoting the development or worsening of coronary ischemia. Chronic coronary syndrome alters the structure and function of gap junction proteins, impacting action potential conduction and sustaining focal ectopic activity in atrial myocardium. They share common risk factors such as hypertension, obesity, type 2 diabetes mellitus, and dyslipidemia. Breaking this vicious cycle through controlling risk factors, drug therapies (including antithrombotic therapy), and interventional therapies (revascularization and catheter ablation) is vital for patient prognosis.
Review
Health Care Sciences & Services
Ioannis Mavroudis, Ioana-Miruna Balmus, Alin Ciobica, Alina-Costina Luca, Dragos Lucian Gorgan, Irina Dobrin, Irina Luciana Gurzu
Summary: Chronic traumatic encephalopathy (CTE) is a complex pathological condition resulting from repeated head traumas, with a diagnosis currently only possible postmortem. This study discusses the limitations of available diagnostic criteria for traumatic encephalopathy syndrome (TES)/CTE and proposes a diagnostic algorithm for a more accurate procedure.
Article
Medicine, General & Internal
Viviana Aursulesei Onofrei, Carmen Lacramioara Zamfir, Ecaterina Anisie, Alexandr Ceasovschih, Mihai Constantin, Florin Mitu, Cristina Andreea Adam, Elena-Daniela Grigorescu, Antoneta Dacia Petroaie, Daniel Timofte
Summary: This study aimed to identify imaging parameters for predicting early-onset arterial stiffness. Our results suggest that epicardial adipose tissue thickness, carotid intima-media thickness, relative wall thickness, and carotid cross-sectional area might be useful parameters for early prediction of arterial stiffness in patients with morbid obesity.
MEDICINA-LITHUANIA
(2023)
Review
Biochemistry & Molecular Biology
Matei Palimariciuc, Ioana-Miruna Balmus, Bogdan Gireada, Alin Ciobica, Roxana Chirita, Alin-Constantin Iordache, Mihai Apostu, Romeo Petru Dobrin
Summary: Dementia is a clinical syndrome characterized by progressive decline in various cognitive functions, and Alzheimer’s disease is the most common cause of dementia. Despite extensive research, treatment options for AD are still limited, and a nutritional approach could be a promising way to develop improved management strategies. Nutritional interventions and the role of nutrients in AD pathology could provide novel treatment options for neurodegenerative disorders.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Review
Medicine, General & Internal
Mihai Hogas, Cristian Statescu, Manuela Padurariu, Alin Ciobica, Stefana Catalina Bilha, Anca Haisan, Daniel Timofte, Simona Hogas
Summary: Dietary salt intake is a controversial issue, as excessive sodium intake can negatively affect blood pressure and cardiovascular health in certain individuals, while moderate salt restriction can help lower blood pressure and improve cardiovascular health.
MEDICINA-LITHUANIA
(2022)
Review
Medicine, General & Internal
Tudor Florea, Matei Palimariciuc, Ana Caterina Cristofor, Irina Dobrin, Roxana Chirita, Magdalena Birsan, Romeo Petru Dobrin, Manuela Padurariu
Summary: This expert review examines the role of oxytocin as a neuromodulator in the brain and its potential therapeutic value in treating psychiatric disorders. Studies have found correlations between oxytocin levels and symptoms such as anxiety and depression, as well as positive effects on social behavior. Oxytocin is also linked with other neurotransmitter systems that play a role in stress response and social support group formation.
MEDICINA-LITHUANIA
(2022)