Taming tosyl azide: the development of a scalable continuous diazo transfer process

Continuous-Flow Technology-A Tool for the Safe Manufacturing of Active Pharmaceutical Ingredients

(2015) Bernhard Gutmann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Modern Organic Synthesis with α-Diazocarbonyl Compounds

(2015) Alan Ford et al.   CHEMICAL REVIEWS

Rapid Generation and Safe Use of Carbenes Enabled by a Novel Flow Protocol with In-line IR spectroscopy

(2015) Simon T. R. Müller et al.   CHEMISTRY-A EUROPEAN JOURNAL

Cyclopropanation using flow-generated diazo compounds

(2015) Nuria M. Roda et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Toward a Large-Scale Approach to Milnacipran Analogues Using Diazo Compounds in Flow Chemistry

(2015) Simon T. R. Müller et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

NaOH/Et3N-Promoted Stereoselective One-Pot Synthesis ofα-Diazo Oxime Ethers via Diazo Transfer Reaction

(2015) Bharath Kumar Kuruba et al.   SYNTHETIC COMMUNICATIONS

Synthesis of 1-arylcycloprop-2-ene carboxylates with non-substituted double bond via a Rh(II)-catalyzed cyclopropenation of trimethylsilylacetylene with coarsely purified aryldiazoacetates

(2015) Andrew Edwards et al.   TETRAHEDRON

Flow chemistry as a discovery tool to access sp2–sp3 cross-coupling reactions via diazo compounds

(2015) Duc N. Tran et al.   Chemical Science

From Indoles to Carbazoles: Tandem Cp*Rh(III)-Catalyzed C–H Activation/Brønsted Acid-Catalyzed Cyclization Reactions

(2015) Jia-Qiang Wu et al.   ACS Catalysis

α-Diazo β-Keto Ester as Precursor to Aromatic CH Insertion and Wolff Rearrangement with Different Directing Groups

(2014) Biao Ma et al.   ADVANCED SYNTHESIS & CATALYSIS

Back Pressure Regulation of Slurry-Forming Reactions in Continuous Flow

(2014) Benjamin J. Deadman et al.   CHEMICAL ENGINEERING & TECHNOLOGY

Multicomponent, Flow Diazotization/Mizoroki-Heck Coupling Protocol: Dispelling Myths about Working with Diazonium Salts

(2014) Kumara S. Nalivela et al.   CHEMISTRY-A EUROPEAN JOURNAL

Multistep Flow Synthesis of 5-Amino-2-aryl-2H-[1,2,3]-triazole-4-carbonitriles

(2014) Jérôme Jacq et al.   CHEMISTRY-A EUROPEAN JOURNAL

Taming Hazardous Chemistry in Flow: The Continuous Processing of Diazo and Diazonium Compounds

(2014) Benjamin J. Deadman et al.   CHEMISTRY-A EUROPEAN JOURNAL

Diazo Compounds in Continuous-Flow Technology

(2014) Simon T. R. Müller et al.   ChemSusChem

Hetero-Wolff Rearrangement of an α-Sulfinyl Carbene: Thermally Activated Intersystem Crossing of the Lowest Excited Triplet State of a Ground-State Singlet Carbene

(2014) Orlagh C. M. O'Sullivan et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Continuous Flow Synthesis of α-Halo Ketones: Essential Building Blocks of Antiretroviral Agents

(2014) Vagner D. Pinho et al.   JOURNAL OF ORGANIC CHEMISTRY

Continuous-Flow Heck–Matsuda Reaction: Homogeneous versus Heterogeneous Palladium Catalysts

(2014) Nicolas Oger et al.   JOURNAL OF ORGANIC CHEMISTRY

Reactivity of Vinyl Phosphonate Containing Diazoesters: Formation, Reactivity, and Utility

(2014) Jin Wang et al.   ORGANIC LETTERS

Continuous Flow Total Synthesis of Rufinamide

(2014) Ping Zhang et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Continuous flow synthesis of β-amino acids from α-amino acids via Arndt–Eistert homologation

(2014) Vagner D. Pinho et al.   RSC Advances

A Metal-Free Multicomponent Cascade Reaction for the Regiospecific Synthesis of 1,5-Disubstituted 1,2,3-Triazoles

(2013) Guolin Cheng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Flow chemistry syntheses of natural products

(2013) Julio C. Pastre et al.   CHEMICAL SOCIETY REVIEWS

A Machine-Assisted Flow Synthesis of SR48692: A Probe for the Investigation of Neurotensin Receptor-1

(2013) Claudio Battilocchio et al.   CHEMISTRY-A EUROPEAN JOURNAL

Continuous flow synthesis of toxic ethyl diazoacetate for utilization in an integrated microfluidic system

(2013) Ram Awatar Maurya et al.   GREEN CHEMISTRY

Applying Flow Chemistry: Methods, Materials, and Multistep Synthesis

(2013) D. Tyler McQuade et al.   JOURNAL OF ORGANIC CHEMISTRY

Design and synthesis of stable α-diazo-β-oxo sulfoxides

(2013) Stuart G. Collins et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Continuous Flow Generation and Reactions of Anhydrous Diazomethane Using a Teflon AF-2400 Tube-in-Tube Reactor

(2013) Federica Mastronardi et al.   ORGANIC LETTERS

Continuous-flow generation of diazoesters and their direct use in S–H and P–H insertion reactions: synthesis of α-sulfanyl, α-sulfonyl, and α-phosphono carboxylates

(2013) Hannah E. Bartrum et al.   TETRAHEDRON

Flow Chemistry - A Key Enabling Technology for (Multistep) Organic Synthesis

(2012) Jens Wegner et al.   ADVANCED SYNTHESIS & CATALYSIS

Sensitivities of Some Imidazole-1-sulfonyl Azide Salts

(2012) Niko Fischer et al.   JOURNAL OF ORGANIC CHEMISTRY

Continuous-Flow Synthesis of Monoarylated Acetaldehydes Using Aryldiazonium Salts

(2012) Natalia Chernyak et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Continuous Flow Production of Thermally Unstable Intermediates in a Microreactor with Inline IR-Analysis: Controlled Vilsmeier–Haack Formylation of Electron-Rich Arenes

(2012) Sebastiaan (Bas) A. M. W. van den Broek et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Managing Solids in Microreactors for the Upstream Continuous Processing of Fine Chemicals

(2012) Ryan L. Hartman   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Two-Step Flow Synthesis of Biarylmethanes by Reductive Arylation of Tosylhydrazones

(2012) Lukas Kupracz et al.   Journal of Flow Chemistry

Deciding Whether To Go with the Flow: Evaluating the Merits of Flow Reactors for Synthesis

(2011) Ryan L. Hartman et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rapid Access to α-Alkoxy and α-Amino Acid Derivatives through Safe Continuous-Flow Generation of Diazoesters

(2011) Hannah E. Bartrum et al.   CHEMISTRY-A EUROPEAN JOURNAL

A fully automated, multistep flow synthesis of 5-amino-4-cyano-1,2,3-triazoles

(2011) Catherine J. Smith et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Continuous Flow Processing of Slurries: Evaluation of an Agitated Cell Reactor

(2011) Duncan L. Browne et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Synthesis of 5-Substituted 1H-Tetrazoles from Nitriles and Hydrazoic Acid by Using a Safe and Scalable High-Temperature Microreactor Approach

(2010) Bernhard Gutmann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Continuous flow azide formation: Optimization and scale-up

(2010) Mariëlle M.E. Delville et al.   CHEMICAL ENGINEERING JOURNAL

Highly Enantioselective Intramolecular Copper Catalyzed C−H Insertion Reactions of α-Diazosulfones

(2010) Christopher J. Flynn et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Preparation of arylsulfonyl chlorides by chlorosulfonylation of in situ generated diazonium salts using a continuous flow reactor

(2010) Laia Malet-Sanz et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Asymmetric copper-catalysed intramolecular C–H insertion reactions of α-diazo-β-keto sulfones

(2010) Catherine N. Slattery et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Safe and Reliable Synthesis of Diazoketones and Quinoxalines in a Continuous Flow Reactor

(2010) Laetitia J. Martin et al.   ORGANIC LETTERS

ReactIR Flow Cell: A New Analytical Tool for Continuous Flow Chemical Processing

(2010) Catherine F. Carter et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Catalytic asymmetric C–H insertion reactions of α-diazocarbonyl compounds

(2010) Catherine N. Slattery et al.   TETRAHEDRON

Continuous flow multi-step organic synthesis

(2010) Damien Webb et al.   Chemical Science

New Syntheses of Diazo Compounds

(2009) Gerhard Maas   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Controlling hazardous chemicals in microreactors: Synthesis with iodine azide

(2009) Johan C Brandt et al.   Beilstein Journal of Organic Chemistry

Catalytic Carbene Insertion into C−H Bonds

(2009) Michael P. Doyle et al.   CHEMICAL REVIEWS

Improved Synthesis of 1-(Azidomethyl)-3,5-bis-(trifluoromethyl)benzene: Development of Batch and Microflow Azide Processes

(2009) Michael E. Kopach et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Heck reactions using segmented flow conditions

(2009) Batoul Ahmed-Omer et al.   TETRAHEDRON LETTERS

C−H Carbene Insertion of α-Diazo Acetamides by Photolysis in Non-Conventional Media

(2008) Nuno R. Candeias et al.   JOURNAL OF ORGANIC CHEMISTRY

Direct ionic liquid promoted organocatalyzed diazo-transfer reactions: diversity-oriented synthesis of diazo-compounds

(2008) Dhevalapally B. Ramachary et al.   TETRAHEDRON LETTERS