Flow chemistry as a discovery tool to access sp2–sp3 cross-coupling reactions via diazo compounds

The rapid synthesis of oxazolines and their heterogeneous oxidation to oxazoles under flow conditions

(2015) Steffen Glöckner et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Continuous-Flow Synthesis of Functionalized Phenols by Aerobic Oxidation of Grignard Reagents

(2014) Zhi He et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of α-Aryl Esters and Nitriles: Deaminative Coupling of α-Aminoesters and α-Aminoacetonitriles with Arylboronic Acids

(2014) Guojiao Wu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Accelerating Spirocyclic Polyketide Synthesis using Flow Chemistry

(2014) Sean Newton et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Flow Chemistry Meets Advanced Functional Materials

(2014) Rebecca M. Myers et al.   CHEMISTRY-A EUROPEAN JOURNAL

Switchable 2,2,2-Trifluoroethylation andgem-Difluorovinylation of Organoboronic Acids with 2,2,2-Trifluorodiazoethane

(2014) Guojiao Wu et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

A General Continuous Flow Method for Palladium Catalysed Carbonylation Reactions Using Single and Multiple Tube-in-Tube Gas-Liquid Microreactors

(2014) Ulrike Gross et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Mild and Selective Heterogeneous Catalytic Hydration of Nitriles to Amides by Flowing through Manganese Dioxide

(2014) Claudio Battilocchio et al.   ORGANIC LETTERS

Preparation of Unsymmetrical Ketones from Tosylhydrazones and Aromatic Aldehydes via Formyl C–H Bond Insertion

(2014) Daniel M. Allwood et al.   ORGANIC LETTERS

Biocatalytic Production of Catechols Using a High Pressure Tube-in-Tube Segmented Flow Microreactor

(2014) Bartłomiej Tomaszewski et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Controlled multistep synthesis in a three-phase droplet reactor

(2014) Adrian M. Nightingale et al.   Nature Communications

Heating under High-Frequency Inductive Conditions: Application to the Continuous Synthesis of the Neurolepticum Olanzapine (Zyprexa)

(2013) Jan Hartwig et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The rapid generation of isothiocyanates in flow

(2013) Marcus Baumann et al.   Beilstein Journal of Organic Chemistry

Flow chemistry syntheses of natural products

(2013) Julio C. Pastre et al.   CHEMICAL SOCIETY REVIEWS

A prototype device for evaporation in batch and flow chemical processes

(2013) Benjamin J. Deadman et al.   GREEN CHEMISTRY

Synthesis of Acyclic Ketones by Catalytic, Bidirectional Homologation of Formaldehyde with Nonstabilized Diazoalkanes. Application of a Chiral Diazomethyl(pyrrolidine) in Total Syntheses of Erythroxylon Alkaloids

(2013) Andrew J. Wommack et al.   JOURNAL OF ORGANIC CHEMISTRY

Metal-Free Coupling of Saturated Heterocyclic Sulfonylhydrazones with Boronic Acids

(2013) Daniel M. Allwood et al.   JOURNAL OF ORGANIC CHEMISTRY

Continuous Flow Generation and Reactions of Anhydrous Diazomethane Using a Teflon AF-2400 Tube-in-Tube Reactor

(2013) Federica Mastronardi et al.   ORGANIC LETTERS

Flow Chemistry - A Key Enabling Technology for (Multistep) Organic Synthesis

(2012) Jens Wegner et al.   ADVANCED SYNTHESIS & CATALYSIS

Asymmetric Homogeneous Hydrogenation in Flow using a Tube-in-Tube Reactor

(2012) Sean Newton et al.   ADVANCED SYNTHESIS & CATALYSIS

Olefination of Carbonyl Compounds through Reductive Coupling of Alkenylboronic Acids and Tosylhydrazones

(2012) M. Carmen Pérez-Aguilar et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Continuous-Flow Synthesis of the Anti-Malaria Drug Artemisinin

(2012) François Lévesque et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Flow Chemistry Syntheses of Styrenes, Unsymmetrical Stilbenes and Branched Aldehydes

(2012) Samuel L. Bourne et al.   ChemCatChem

On Being Green: Can Flow Chemistry Help?

(2012) Steven V. Ley   CHEMICAL RECORD

The integration of flow reactors into synthetic organic chemistry

(2012) Ian R. Baxendale   JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY

Continuous Flow Synthesis. A Pharma Perspective

(2012) Laia Malet-Sanz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Titration of Nonstabilized Diazoalkane Solutions by Fluorine NMR

(2012) Victor L. Rendina et al.   JOURNAL OF ORGANIC CHEMISTRY

Flow synthesis using gaseous ammonia in a Teflon AF-2400 tube-in-tube reactor: Paal–Knorr pyrrole formation and gas concentration measurement by inline flow titration

(2012) Philippa B. Cranwell et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Facile Stoichiometric Reductions in Flow: An Example of Artemisinin

(2012) Xiaolei Fan et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Iron-Catalyzed Cyclopropanation in 6 M KOH with in Situ Generation of Diazomethane

(2012) B. Morandi et al.   SCIENCE

Two-Step Flow Synthesis of Biarylmethanes by Reductive Arylation of Tosylhydrazones

(2012) Lukas Kupracz et al.   Journal of Flow Chemistry

Continuous In Situ Generation, Separation, and Reaction of Diazomethane in a Dual-Channel Microreactor

(2011) Ram Awatar Maurya et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Deciding Whether To Go with the Flow: Evaluating the Merits of Flow Reactors for Synthesis

(2011) Ryan L. Hartman et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Application of Barluenga Boronic Coupling (BBC) to the Parallel Synthesis of Drug-like and Drug Fragment-like Molecules

(2011) Shoko Nakagawa et al.   ChemMedChem

The Oxygen-Mediated Synthesis of 1,3-Butadiynes in Continuous Flow: Using Teflon AF-2400 to Effect Gas/Liquid Contact

(2011) Trine P. Petersen et al.   ChemSusChem

Continuous flow reactors: a perspective

(2011) Charlotte Wiles et al.   GREEN CHEMISTRY

Scalable in Situ Diazomethane Generation in Continuous-Flow Reactors

(2011) Emiliano Rossi et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

A flow-microreactor approach to protecting-group-free synthesis using organolithium compounds

(2011) Heejin Kim et al.   Nature Communications

To Protonate or Alkylate? Stereoselective Brønsted Acid Catalysis of CC Bond Formation Using Diazoalkanes

(2010) Jeffrey N. Johnston et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Safe and Reliable Synthesis of Diazoketones and Quinoxalines in a Continuous Flow Reactor

(2010) Laetitia J. Martin et al.   ORGANIC LETTERS

New Syntheses of Diazo Compounds

(2009) Gerhard Maas   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

In SituGeneration of Zinc Carbenoids from Diazo Compounds and Zinc Salts: Asymmetric Synthesis of 1,2,3-Substituted Cyclopropanes

(2009) Sébastien R. Goudreau et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalytic Homologation of Cycloalkanones with Substituted Diazomethanes. Mild and Efficient Single-Step Access to α-Tertiary and α-Quaternary Carbonyl Compounds

(2009) David C. Moebius et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Metal-free carbon–carbon bond-forming reductive coupling between boronic acids and tosylhydrazones

(2009) José Barluenga et al.   Nature Chemistry

Arylation and Vinylation of α-Diazocarbonyl Compounds with Boroxines

(2009) Cheng Peng et al.   ORGANIC LETTERS

Continuous Production of the Diazomethane PrecursorN-Methyl-N-nitroso-p-toluenesulfonamide: Batch Optimization and Transfer into a Microreactor Setup

(2009) Michael Struempel et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT