A new vinyl selenone-based domino approach to spirocyclopropyl oxindoles endowed with anti-HIV RT activity

Recent advances in catalysis in micellar media

(2015) Giorgio La Sorella et al.   GREEN CHEMISTRY

Design and Synthesis of DiselenoBisBenzamides (DISeBAs) as Nucleocapsid Protein 7 (NCp7) Inhibitors with anti-HIV Activity

(2015) Luca Sancineto et al.   JOURNAL OF MEDICINAL CHEMISTRY

Methyl-α-d-2-selenonyl Pent-2-enofuranoside: A Reactive Selenosugar for the Diversity Oriented Synthesis of Enantiomerically Pure Heterocycles, Carbocycles, and Isonucleosides

(2015) Atanu Bhaumik et al.   JOURNAL OF ORGANIC CHEMISTRY

Selenium Catalyzed Oxidation of Aldehydes: Green Synthesis of Carboxylic Acids and Esters

(2015) Luca Sancineto et al.   MOLECULES

One-shot access to α,β-difunctionalized azepenes and dehydropiperidines by reductive cross-coupling of α-selenonyl-β-selenyl enamides with organic bromides

(2015) Timothy K. Beng et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Highly Diastereoselective Synthesis of Spirocyclopropane-oxindoles Using InCl3 as a Catalyst in Water

(2015) Sengodagounder Muthusamy et al.   SYNLETT

Stereochemical implications in the synthesis of 3,3′-spirocyclopropyl oxindoles from β-aryl/alkyl-substituted alkylidene oxindoles

(2015) Erin E. Wilson et al.   TETRAHEDRON

Catalytic asymmetric synthesis of polysubstituted spirocyclopropyl oxindoles: organocatalysis versus transition metal catalysis

(2015) Zhong-Yan Cao et al.   Organic Chemistry Frontiers

Exploiting the anti-HIV 6-desfluoroquinolones to design multiple ligands

(2014) Luca Sancineto et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The use of spirocyclic scaffolds in drug discovery

(2014) Yajun Zheng et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Asymmetric Diastereoselective Synthesis of Spirocyclopropane Derivatives of Oxindole

(2014) Maksim Ošeka et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

The Discovery of Polo-Like Kinase 4 Inhibitors: Identification of (1R,2S)-2-(3-((E)-4-(((cis)-2,6-Dimethylmorpholino)methyl)styryl)-1H-indazol-6-yl)-5′-methoxyspiro[cyclopropane-1,3′-indolin]-2′-one (CFI-400945) as a Potent, Orally Active Antitumor Agent

(2014) Peter B. Sampson et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Discovery of Polo-Like Kinase 4 Inhibitors: Design and Optimization of Spiro[cyclopropane-1,3′[3H]indol]-2′(1′H)-ones as Orally Bioavailable Antitumor Agents

(2014) Peter B. Sampson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Enantiopure 1,4,5-Trisubstituted 1,2,3-Triazoles from Carbohydrates: Applications of Organoselenium Chemistry

(2014) Atanu Bhaumik et al.   JOURNAL OF ORGANIC CHEMISTRY

Diastereoselective Synthesis of Functionalized Spirocyclopropyl Oxindoles via P(NMe2)3-Mediated Reductive Cyclopropanation

(2014) Rong Zhou et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of CF3-Containing 3,3′-Cyclopropyl Spirooxindoles by Sequential [3 + 2] Cycloaddition/Ring Contraction of Ylideneoxindoles with 2,2,2-Trifluorodiazoethane

(2014) Tian-Ren Li et al.   JOURNAL OF ORGANIC CHEMISTRY

Triple Role of Phenylselenonyl Group Enabled a One-Pot Synthesis of 1,3-Oxazinan-2-ones From α-Isocyanoacetates, Phenyl Vinyl Selenones, and Water

(2014) Thomas Buyck et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Highly diastereoselective synthesis of spiro[cyclopropane-1,3′-indolin]-2′-ones via catalyst-free cyclopropanation using ethyl diazoacetate

(2014) Ram Awatar Maurya et al.   TETRAHEDRON

Solvent- and transition metal-free synthesis of spiro[cyclopropane-1,3-oxindoles] from cyclic diazoamides

(2014) Sengodagounder Muthusamy et al.   TETRAHEDRON LETTERS

Catalyst and solvent-free cyclopropanation of electron-deficient olefins with cyclic diazoamides for the synthesis of spiro[cyclopropane-1,3′-indolin]-2′-one derivatives

(2014) Govindaraju Karthik et al.   TETRAHEDRON LETTERS

1,3-Carbon D–A strategy for [3 + 2] cycloadditions/annulations with imines: synthesis of functionalized pyrrolidines and related alkaloids

(2014) Indresh Kumar   RSC Advances

Diastereoselective synthesis of spiro[cyclopropane-1,3′-indolin]-2′-ones through metal-free cyclopropanation using tosylhydrazone salts

(2014) Jeevak Sopanrao Kapure et al.   RSC Advances

Synthesis of Cyclopropane Spirooxindoles by means of a Vinylogous Organocatalytic Cascade

(2014) Rodrigo César da Silva et al.   Asian Journal of Organic Chemistry

3-Chlorooxindoles: Versatile Starting Materials for Asymmetric Organocatalytic Synthesis of Spirooxindoles

(2013) Artur Noole et al.   ADVANCED SYNTHESIS & CATALYSIS

Catalytic Enantioselective Michael Addition of α-Aryl-α-Isocyanoacetates to Vinyl Selenone: Synthesis of α,α-Disubstituted α-Amino Acids and (+)- and (−)-Trigonoliimine A

(2013) Thomas Buyck et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Substituted indolin-2-ones as p90 ribosomal S6 protein kinase 2 (RSK2) inhibitors: Molecular docking simulation and structure–activity relationship analysis

(2013) Ye Zhong et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Asymmetric synthesis of 3-spirocyclopropyl-2-oxindoles via intramolecular trapping of chiral aza-ortho-xylylene

(2013) Xiaowei Dou et al.   CHEMICAL COMMUNICATIONS

Benign by design: catalyst-free in-water, on-water green chemical methodologies in organic synthesis

(2013) Manoj B. Gawande et al.   CHEMICAL SOCIETY REVIEWS

Computer-Aided Design, Synthesis and Validation of 2-Phenylquinazolinone Fragments as CDK9 Inhibitors with Anti-HIV-1 Tat-Mediated Transcription Activity

(2013) Luca Sancineto et al.   ChemMedChem

Blocking HIV-1 Replication by Targeting the Tat-Hijacked Transcriptional Machinery

(2013) Serena Massari et al.   CURRENT PHARMACEUTICAL DESIGN

Michael Additions in Aqueous Media: “On-Water” and “In-Water” Processes from α-Nitro Ketones and Their Anions

(2013) Giorgio Giorgi et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

“On-water” thiolysis of epoxides promoted by PhSZnBr

(2013) Simona Propersi et al.   Journal of Sulfur Chemistry

Highly Stereoselective Olefin Cyclopropanation of Diazooxindoles Catalyzed by a C2-Symmetric Spiroketal Bisphosphine/Au(I) Complex

(2013) Zhong-Yan Cao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Diverse reactivity in microwave-promoted catalyst-free coupling of substituted anilines with ethyl trifluoropyruvate and biological evaluation

(2013) Chen Zhang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Silver-Promoted, Palladium-Catalyzed Direct Arylation of Cyclopropanes: Facile Access to Spiro 3,3′-Cyclopropyl Oxindoles

(2013) Carolyn L. Ladd et al.   ORGANIC LETTERS

Synthesis of γ-lactams via a domino Michael addition/cyclization reaction of vinyl selenone with substituted amides

(2013) Silvia Sternativo et al.   TETRAHEDRON LETTERS

Diastereodivergent Synthesis of 3-Spirocyclopropyl-2-oxindoles through Direct Enantioselective Cyclopropanation of Oxindoles

(2012) Xiaowei Dou et al.   CHEMISTRY-A EUROPEAN JOURNAL

Highly Enantio- and Diastereoselective Generation of Two Quaternary Centers in Spirocyclopropanation of Oxindole Derivatives.

(2012) Artur Noole et al.   CHEMISTRY-A EUROPEAN JOURNAL

On water preparation of phenylselenoesters

(2012) Claudio Santi et al.   GREEN CHEMISTRY

Regioselective Synthesis of Heteroaryl Triflones by LDA (Lithium Diisopropylamide)-Mediated Anionic Thia-Fries Rearrangement

(2012) Xiu-Hua Xu et al.   ORGANIC LETTERS

A Highly Diastereo- and Enantioselective Hg(II)-Catalyzed Cyclopropanation of Diazooxindoles and Alkenes

(2012) Zhong-Yan Cao et al.   ORGANIC LETTERS

Organocatalytic Michael addition of indanone carboxylates to vinyl selenone for the asymmetric synthesis of polycyclic pyrrolidines

(2012) Silvia Sternativo et al.   TETRAHEDRON

Vinyl selenones: annulation agents for the synthesis of six-membered benzo-1,4-heterocyclic compounds

(2012) Luana Bagnoli et al.   TETRAHEDRON

Highly stereoselective cyclopropanation of glycals with cyclic diazoamides: a facile synthesis of spirooxindolyl sugar derivatives

(2012) B.V. Subba Reddy et al.   TETRAHEDRON LETTERS

A Highly Enantioselective One-Pot Synthesis of Spirolactones by an Organocatalyzed Michael Addition/Cyclization Sequence

(2011) Silvia Sternativo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Highly enantioselective Michael addition of 2-oxindoles to vinyl selenone in RTILs catalyzed by a Cinchona alkaloid-based thiourea

(2011) Tao Zhang et al.   CHEMICAL COMMUNICATIONS

Organocatalytic Michael-Alkylation Cascade: The Enantioselective Nitrocyclopropanation of Oxindoles

(2011) Fabio Pesciaioli et al.   CHEMISTRY-A EUROPEAN JOURNAL

Rhodium(II) acetate-catalyzed stereoselective synthesis, SAR and anti-HIV activity of novel oxindoles bearing cyclopropane ring

(2011) Garima Kumari et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of Enantiopure 1,4-Dioxanes, Morpholines, and Piperazines from the Reaction of Chiral 1,2-Diols, Amino Alcohols, and Diamines with Vinyl Selenones

(2010) Luana Bagnoli et al.   CHEMISTRY-A EUROPEAN JOURNAL

Studies of Anti-HIV Transcription Inhibitor Quinolones: Identification of Potent N1-Vinyl Derivatives

(2010) Oriana Tabarrini et al.   ChemMedChem

6-desfluoroquinolones as HIV-1 Tat-mediated transcription inhibitors

(2010) Oriana Tabarrini et al.   Future Medicinal Chemistry

One-pot approach for the stereoselective synthesis of spirocyclopropyl oxindoles from isatins and arsonium salts

(2010) Haigang Yu et al.   TETRAHEDRON

One-pot synthesis of aziridines from vinyl selenones and variously functionalized primary amines

(2010) Silvia Sternativo et al.   TETRAHEDRON

A New Stereoselective Synthesis of Cyclopropanes Containing Quaternary Stereocentres via Organocatalytic Michael Addition to Vinyl Selenones

(2009) Francesca Marini et al.   ADVANCED SYNTHESIS & CATALYSIS

Preparation of both enantiomers of cyclopropane derivatives from the reaction of vinyl selenones with di-(−)-bornyl malonate

(2009) Luana Bagnoli et al.   TETRAHEDRON-ASYMMETRY

Studies on anti-HIV quinolones: New insights on the C-6 position

(2008) Serena Massari et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Preparation of the First Bench-Stable Phenyl Selenolate: an Interesting “On Water” Nucleophilic Reagent

(2008) Claudio Santi et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Tetrazolium-based colorimetric assay for the detection of HIV replication inhibitors: revisited 20 years later

(2008) Christophe Pannecouque et al.   Nature Protocols