DBC2/RhoBTB2 functions as a tumor suppressor protein via Musashi-2 ubiquitination in breast cancer

MSI2 is required for maintaining activated myelodysplastic syndrome stem cells

(2016) James Taggart et al.   Nature Communications

Musashi-2 Silencing Exerts Potent Activity against Acute Myeloid Leukemia and Enhances Chemosensitivity to Daunorubicin

(2015) Yixiang Han et al.   PLoS One

Transformation of the intestinal epithelium by the MSI2 RNA-binding protein

(2015) Shan Wang et al.   Nature Communications

The Msi Family of RNA-Binding Proteins Function Redundantly as Intestinal Oncoproteins

(2015) Ning Li et al.   Cell Reports

Hsp90-Dependent Assembly of the DBC2/RhoBTB2-Cullin3 E3-Ligase Complex

(2014) Jacob R. Manjarrez et al.   PLoS One

Musashi proteins are post-transcriptional regulators of the epithelial-luminal cell state

(2014) Yarden Katz et al.   eLife

Decreased expression of the DBC2 gene and its clinicopathological significance in breast cancer: correlation with aberrant DNA methylation

(2013) Linlin Han et al.   BIOTECHNOLOGY LETTERS

Downregulated RhoBTB2 Expression Contributes to Poor Outcome in Osteosarcoma Patients

(2013) Zhe Jin et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Musashi2 modulates K562 leukemic cell proliferation and apoptosis involving the MAPK pathway

(2013) Huijuan Zhang et al.   EXPERIMENTAL CELL RESEARCH

Musashi2 predicts poor prognosis and invasion in hepatocellular carcinoma by driving epithelial-mesenchymal transition

(2013) Lu He et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The SOX2-Interactome in Brain Cancer Cells Identifies the Requirement of MSI2 and USP9X for the Growth of Brain Tumor Cells

(2013) Jesse L. Cox et al.   PLoS One

Epigenetic Regulation of Cancer Stem Cell Genes in Triple-Negative Breast Cancer

(2012) Naofumi Kagara et al.   AMERICAN JOURNAL OF PATHOLOGY

Prognostic significance of expression levels of stem cell regulators MSI2 and NUMB in acute myeloid leukemia

(2012) Felicitas Thol et al.   ANNALS OF HEMATOLOGY

Loss of DBC2 Expression is an Early and Progressive Event in the Development of Lung Adenocarcinoma

(2012) Wei Dong et al.   Asian Pacific Journal of Cancer Prevention

Akt is negatively regulated by the MULAN E3 ligase

(2012) Seunghee Bae et al.   CELL RESEARCH

MSI2 protein expression predicts unfavorable outcome in acute myeloid leukemia

(2011) R. J. Byers et al.   BLOOD

RhoBTB2 (DBC2) comes of age as a multifunctional tumor suppressor

(2011) Scott N. Freeman et al.   CANCER BIOLOGY & THERAPY

E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53

(2011) J H Jung et al.   CELL DEATH AND DIFFERENTIATION

RhoBTB2 (DBC2) functions as tumor suppressor via inhibiting proliferation, preventing colony formation and inducing apoptosis in breast cancer cells

(2011) Haiting Mao et al.   GENE

The RNA binding protein Musashi1 regulates apoptosis, gene expression and stress granule formation in urothelial carcinoma cells

(2010) Parvaneh Nikpour et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia

(2010) Michael G Kharas et al.   NATURE MEDICINE

Ubiquitin-like protein conjugation and the ubiquitin–proteasome system as drug targets

(2010) Lynn Bedford et al.   NATURE REVIEWS DRUG DISCOVERY

Cullin3-Based Polyubiquitination and p62-Dependent Aggregation of Caspase-8 Mediate Extrinsic Apoptosis Signaling

(2009) Zhaoyu Jin et al.   CELL

The Cul3–KLHL21 E3 ubiquitin ligase targets Aurora B to midzone microtubules in anaphase and is required for cytokinesis

(2009) Sarah Maerki et al.   JOURNAL OF CELL BIOLOGY

Exploring the Linkage Dependence of Polyubiquitin Conformations Using Molecular Modeling

(2009) David Fushman et al.   JOURNAL OF MOLECULAR BIOLOGY

Cullin Mediates Degradation of RhoA through Evolutionarily Conserved BTB Adaptors to Control Actin Cytoskeleton Structure and Cell Movement

(2009) Yuezhou Chen et al.   MOLECULAR CELL

Genetic analysis of theDBC2gene in gastric cancer

(2008) Yong Gu Cho et al.   ACTA ONCOLOGICA

Characterization of RhoBTB-dependent Cul3 ubiquitin ligase complexes — Evidence for an autoregulatory mechanism

(2008) Jessica Berthold et al.   EXPERIMENTAL CELL RESEARCH

DBC2 gene is silenced by promoter methylation in bladder cancer

(2008) Ying Shi et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS