Inhibition of KPNA4 attenuates prostate cancer metastasis

Cancer statistics, 2016

(2016) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Driven to metastasize: Kinases as potential therapeutic targets in prostate cancer

(2016) Felix Y. Feng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The TGF-β Signaling Regulator PMEPA1 Suppresses Prostate Cancer Metastases to Bone

(2015) Pierrick G.J. Fournier et al.   CANCER CELL

Blocking Tumor Necrosis Factor   Enhances CD8 T-cell-Dependent Immunity in Experimental Melanoma

(2015) F. Bertrand et al.   CANCER RESEARCH

Targeting Notch Signaling with a Notch2/Notch3 Antagonist (Tarextumab) Inhibits Tumor Growth and Decreases Tumor-Initiating Cell Frequency

(2015) W.-C. Yen et al.   CLINICAL CANCER RESEARCH

Notch promotes recurrence of dormant tumor cells following HER2/neu-targeted therapy

(2015) Daniel L. Abravanel et al.   JOURNAL OF CLINICAL INVESTIGATION

MET is required for the recruitment of anti-tumoural neutrophils

(2015) Veronica Finisguerra et al.   NATURE

Macrophages and cancer: from mechanisms to therapeutic implications

(2015) Renato Ostuni et al.   TRENDS IN IMMUNOLOGY

Glucocorticoids mediate induction of microRNA-708 to suppress ovarian cancer metastasis through targeting Rap1B

(2015) Kai-Ti Lin et al.   Nature Communications

Pharmacological inactivation of CHK1 and WEE1 induces mitotic catastrophe in nasopharyngeal carcinoma cells

(2015) Joyce P.Y. Mak et al.   Oncotarget

Upregulation of miR-181s reverses mesenchymal transition by targeting KPNA4 in glioblastoma

(2015) Hongjun Wang et al.   Scientific Reports

Metformin induces ER stress-dependent apoptosis through miR-708-5p/NNAT pathway in prostate cancer

(2015) J Yang et al.   Oncogenesis

Prostate cancer-derived CCN3 induces M2 macrophage infiltration and contributes to angiogenesis in prostate cancer microenvironment

(2015) Po-Chun Chen et al.   Oncotarget

Acetylation of Snail Modulates the Cytokinome of Cancer Cells to Enhance the Recruitment of Macrophages

(2014) Dennis Shin-Shian Hsu et al.   CANCER CELL

NF- B Gene Signature Predicts Prostate Cancer Progression

(2014) R. Jin et al.   CANCER RESEARCH

miR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2

(2014) Jing Y. Krzeszinski et al.   NATURE

Managing bone metastases and reducing skeletal related events in prostate cancer

(2014) Benjamin A. Gartrell et al.   Nature Reviews Clinical Oncology

Talin1 phosphorylation activates β1 integrins: a novel mechanism to promote prostate cancer bone metastasis

(2014) J-K Jin et al.   ONCOGENE

Inhibition of NF-kappa B signaling restores responsiveness of castrate-resistant prostate cancer cells to anti-androgen treatment by decreasing androgen receptor-variant expression

(2014) R Jin et al.   ONCOGENE

Circulating giant macrophages as a potential biomarker of solid tumors

(2014) Daniel L. Adams et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Key role of endothelial importin-α in VEGF expression and gastric angiogenesis: novel insight into aging gastropathy

(2013) Amrita Ahluwalia et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Suppression of miRNA-708 by Polycomb Group Promotes Metastases by Calcium-Induced Cell Migration

(2013) Seongho Ryu et al.   CANCER CELL

Infiltrating Macrophages Promote Prostate Tumorigenesis via Modulating Androgen Receptor-Mediated CCL4-STAT3 Signaling

(2013) L.-Y. Fang et al.   CANCER RESEARCH

Transmembrane TNF-  Promotes Suppressive Activities of Myeloid-Derived Suppressor Cells via TNFR2

(2013) X. Hu et al.   JOURNAL OF IMMUNOLOGY

Targeting Constitutively Activated β 1 Integrins Inhibits Prostate Cancer Metastasis

(2013) Yu-Chen Lee et al.   MOLECULAR CANCER RESEARCH

NF-κB control of T cell development

(2013) Steve Gerondakis et al.   NATURE IMMUNOLOGY

MicroRNA-19a-3p inhibits breast cancer progression and metastasis by inducing macrophage polarization through downregulated expression of Fra-1 proto-oncogene

(2013) J Yang et al.   ONCOGENE

Molecular Profiling of Multiple Human Cancers Defines an Inflammatory Cancer-Associated Molecular Pattern and Uncovers KPNA2 as a Uniform Poor Prognostic Cancer Marker

(2013) Saleh M. Rachidi et al.   PLoS One

Hydrazinocurcumin Encapsuled Nanoparticles “Re-Educate” Tumor-Associated Macrophages and Exhibit Anti-Tumor Effects on Breast Cancer Following STAT3 Suppression

(2013) Xiwen Zhang et al.   PLoS One

The Drosophila Importin-α3 Is Required for Nuclear Import of Notch In Vivo and It Displays Synergistic Effects with Notch Receptor on Cell Proliferation

(2013) Nalani Sachan et al.   PLoS One

miRNA and mRNA cancer signatures determined by analysis of expression levels in large cohorts of patients

(2013) S. Zadran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

miRNA-708 Control of CD44+ Prostate Cancer-Initiating Cells

(2012) S. Saini et al.   CANCER RESEARCH

Calcitriol Decreases Expression of Importin α3 and Attenuates RelA Translocation in Human Bronchial Smooth Muscle Cells

(2012) Tanupriya Agrawal et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Inflammasomes in carcinogenesis and anticancer immune responses

(2012) Laurence Zitvogel et al.   NATURE IMMUNOLOGY

VCAM-1 Promotes Osteolytic Expansion of Indolent Bone Micrometastasis of Breast Cancer by Engaging α4β1-Positive Osteoclast Progenitors

(2011) Xin Lu et al.   CANCER CELL

The Androgen Receptor Induces Integrin  6 1 to Promote Prostate Tumor Cell Survival via NF- B and Bcl-xL Independently of PI3K Signaling

(2011) L. E. Lamb et al.   CANCER RESEARCH

KPNA2 Expression Is an Independent Adverse Predictor of Biochemical Recurrence after Radical Prostatectomy

(2011) A. Mortezavi et al.   CLINICAL CANCER RESEARCH

TNF-α/NF-κB/Snail pathway in cancer cell migration and invasion

(2010) Y Wu et al.   BRITISH JOURNAL OF CANCER

Aberrant Activation of the Androgen Receptor by NF- B2/p52 in Prostate Cancer Cells

(2010) N. Nadiminty et al.   CANCER RESEARCH

B-cell-derived lymphotoxin promotes castration-resistant prostate cancer

(2010) Massimo Ammirante et al.   NATURE

Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

(2010) Subhra K Biswas et al.   NATURE IMMUNOLOGY

A Destructive Cascade Mediated by CCL2 Facilitates Prostate Cancer Growth in Bone

(2009) Xin Li et al.   CANCER RESEARCH

Prohibitin Inhibits Tumor Necrosis Factor alpha–induced Nuclear Factor-kappa B Nuclear Translocation via the Novel Mechanism of Decreasing Importin α3 Expression

(2009) Arianne L. Theiss et al.   MOLECULAR BIOLOGY OF THE CELL