Article
Biochemistry & Molecular Biology
Kyung-Ha Lee, Hwan-Kwon Do, Do-Yeon Kim, Wanil Kim
Summary: Chlorogenic acid is a polyphenol found in human diet that impacts human cells, promoting procollagen type I production and skin barrier gene expression. It can be used to restore impaired dermal matrix network and epidermal skin barrier.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Review
Dermatology
Mao-Qiang Man, Joan S. Wakefield, Theodora M. Mauro, Peter M. Elias
Summary: Nitric oxide (NO) plays a regulatory role in epidermal permeability barrier functions, affecting processes such as barrier homeostasis and wound healing. While insufficient NO can lead to disorders like diabetes and hypertension, excessive levels can induce cellular oxidative stress. iNOS remains essential for epidermal permeability barrier homeostasis.
EXPERIMENTAL DERMATOLOGY
(2022)
Review
Biology
Juan Wang, Sabine A. Eming, Xiaolei Ding
Summary: This review focuses on the formation of the skin barrier and discusses how mTOR signaling networks regulate epidermal differentiation and skin barrier formation. Understanding metabolic signaling in the epidermis is crucial for developing new pharmacological approaches to promote skin barrier regeneration and treat diseases associated with epidermal barrier defects.
Article
Dermatology
Shuai Shao, Lam C. Tsoi, William R. Swindell, Jiaoling Chen, Ranjitha Uppala, Allison C. Billi, Xianying Xing, Chang Zeng, Mrinal K. Sarkar, Rachael Wasikowski, Yanyun Jiang, Joseph Kirma, Jingru Sun, Olesya Plazyo, Gang Wang, Paul W. Harms, John J. Voorhees, Nicole L. Ward, Feiyang Ma, Matteo Pellegrini, Alexander Merleev, Bethany E. Perez White, Robert L. Modlin, Bogi Andersen, Emanual Maverakis, Stephan Weidinger, J. Michelle Kahlenberg, Johann E. Gudjonsson
Summary: The research reveals the critical role of IRAK2 in the severity of atopic dermatitis and psoriasis, with inhibition of IRAK2 normalizing differentiation and inflammation. These findings suggest that IRAK2 promotes feed-forward amplification of inflammatory responses in the skin through modulation of differentiation pathways and inflammatory responses.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Dermatology
Jinjing Jia, Xiumei Mo, Fenggen Yan, Junfeng Liu, Siqi Ye, Yu Zhang, Ying Lin, Hongyi Li, Dacan Chen
Summary: The study found varying levels of Th1/Th2/Th17/Treg imbalance in patients with atopic dermatitis. YAP was downregulated in Treg cells and upregulated in Th17 cells, while it was downregulated in the AD epidermis. Changes in YAP expression may lead to T cell imbalance and hinder epidermal healing in AD.
JOURNAL OF DERMATOLOGICAL SCIENCE
(2021)
Article
Genetics & Heredity
Mandar Phatak, Shruti Kulkarni, Lee B. Miles, Nazma Anjum, Sebastian Dworkin, Mahendra Sonawane
Summary: Research demonstrates that in zebrafish embryos, epidermal cells that round up due to membrane homeostasis defects can be reintegrated into the epithelium to maintain tissue homeostasis. The transcription factor Grhl3 induces the retention of rounded cells by regulating E-cadherin levels, facilitating cell adhesion, retention, and epidermal architecture in embryos deficient in specific functions. This mechanism of retention of rounded cells is crucial for epithelial homeostasis.
Article
Dermatology
Rachel A. Crompton, Helen Williams, Laura Campbell, Lim Hui Kheng, Charis Saville, David M. Ansell, Adam Reid, Jason Wong, Leah A. Vardy, Matthew J. Hardman, Sheena M. Cruickshank
Summary: Nonhealing wounds represent a significant clinical challenge with limited treatment options. This study reveals a previously unknown intrinsic role of epidermal ARG1 in cutaneous wound healing, highlighting the potential of targeting epidermal ARG1 and its downstream mediators as therapeutic strategies for wound repair.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jian Wang, Zhi-ya Zhang, Jie Jiang, Li Tang, Xiao-yan Wang, Zhen Wang, Xue-lian Yang, Xin-lin Yu, Cheng-chen Huang, Feng Chen, Hai-su Wan, Su-juan Ye
Summary: The histone demethylase KDM2A plays an oncogenic role in esophageal squamous cell carcinoma, with its depletion inhibiting malignant phenotypes and overexpression having the opposite effect. KDM2A induces a set of oncogenic gene expressions while suppressing others, demonstrating its dual role in ESCC cells. Targeted inhibition of upregulated oncogenes in KDM2A-depleted cells shows a synergistic suppressive effect on ESCC malignant phenotypes.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Cell Biology
Cen-Cen Sun, Li Li, Hou-Quan Tao, Zhi-Chen Jiang, Liang Wang, Hui-Ju Wang
Summary: This paper reviewed the pro-tumorigenic and anti-tumorigenic properties of NLRP3 inflammasome in different types of digestive system malignancy, providing promising avenues for new anti-cancer therapies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Attila Placido Sachslehner, Leopold Eckhart
Summary: The epidermal differentiation complex (EDC) is a cluster of genes encoding components of the skin barrier in terrestrial vertebrates. In this study, it was found that caecilians have both SFTP and SEDC genes, suggesting diversification of EDC genes in amphibians. The presence of SEDC-type skin barrier genes in caecilians may have originated either in a common ancestor of tetrapods followed by loss in frogs and salamanders, or through convergent evolution in caecilians and amniotes.
SCIENTIFIC REPORTS
(2022)
Review
Endocrinology & Metabolism
Li Ding, Zijie Liu, Junqi Wang
Summary: This review provides a detailed overview of the role of cystatin C in urogenital malignancy.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Editorial Material
Dermatology
Kira Allmeroth, Martin S. Denzel
Summary: Polyamines play a critical role in keratinocyte differentiation, with AMD1 mediating the shift in polyamine ratios. Targeting polyamine availability may be beneficial in treating hyperproliferative skin disorders.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Milena Wojciechowska, Kinga Scibior, Monika Betyna-Bialek, Ewa Kostrzewska, Oliwia McFarlane
Summary: The study investigated the involvement of periostin (POSTN) in the pathogenesis of psoriasis, finding significantly higher levels of POSTN in psoriasis patients compared to healthy individuals. However, the specific role of POSTN in the development of psoriasis remains unclear, warranting further research to elucidate its mechanism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Alain Lefevre-Utile, Camille Braun, Marek Haftek, Francois Aubin
Summary: The epidermis is a living, multilayered barrier with five functional levels, including physical, chemical, microbial, neuronal, and immune levels, which work together to protect the host from external aggression and maintain its integrity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Hanqian Zhang, Simone Westrom, Per Kappelin, Marie Virtanen, Anders Vahlquist, Hans Torma
Summary: This study re-analyzed two sets of microarray data, identifying 24 upregulated genes and confirming 10 of them to be potentially involved in human epidermal keratinocyte differentiation and important for epidermal repair in a genetic skin disease characterized by barrier failure.
Article
Cell Biology
Ashlee J. Conway, Fiona C. Brown, Elinor J. Hortle, Gaetan Burgio, Simon J. Foote, Craig J. Morton, Stephen M. Jane, David J. Curti
DISEASE MODELS & MECHANISMS
(2018)
Article
Developmental Biology
Ariena Kersbergen, Sarah A. Best, Sebastian Dworkin, Casey Ah-Cann, Michael E. de Vries, Marie-Liesse Asselin-Labat, Matthew E. Ritchie, Stephen M. Jane, Kate D. Sutherland
DEVELOPMENTAL BIOLOGY
(2018)
Review
Biochemistry & Molecular Biology
Stephen J. Goldie, Ginevra Chincarini, Charbel Darido
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Review
Cell Biology
Fiona H. Tan, Yuchen Bai, Pierre Saintigny, Charbel Darido
Article
Oncology
Michael A. Harris, Mark A. Miles, Tanmay M. Shekhar, Carmelo Cerra, Smitha R. Georgy, Stewart D. Ryan, Claire M. Cannon, Christine J. Hawkins
Review
Multidisciplinary Sciences
Henry Badgery, Lynn Chong, Elhadi Iich, Qin Huang, Smitha Rose Georgy, David H. Wang, Matthew Read
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Rajdeep Chakraborty, Karen Vickery, Charbel Darido, Shoba Ranganathan, Honghua Hu
Summary: Oral cancer is a global health issue with low survival rates, and bacterial antigens may interfere with the effectiveness of capsaicin in treating oral cancer cells. Capsaicin's anti-cancer effects on oral cancer cells are significantly reduced by bacterial antigens, suggesting a need for clinical consideration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Rajdeep Chakraborty, Honghua Hu, Charbel Darido, Karen Vickery, Shoba Ranganathan
Summary: The study investigated the effect of the calcium channel blocker ML218 HCl on oral cancer cell proliferation, finding that it effectively reduced LPS-induced proliferation and increased apoptosis and cell death. However, the efficacy of ML218 HCl was significantly reduced in the presence of bacterial antigens.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Yuchen Bai, Jarryd Boath, Gabrielle R. White, Uluvitike G. I. U. Kariyawasam, Camile S. Farah, Charbel Darido
Summary: Oral cancer is a multi-step disease with limited treatment options. The processes of oral cell proliferation, differentiation, and terminal differentiation play crucial roles in maintaining the homeostasis of oral epithelial tissue.
Article
Biochemistry & Molecular Biology
Jemma G. Gasperoni, Jarrad N. Fuller, Charbel Darido, Tomasz Wilanowski, Sebastian Dworkin
Summary: Grainyhead-like (GRHL) factors are critical transcription factors that regulate cellular behaviors during development and in cancer. Identifying and studying the target genes of these factors are essential for discovering potential targets for disease diagnosis, drug discovery, and therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Oncology
Imran Khan, Charbel Darido
Review
Oncology
Rajdeep Chakraborty, Charbel Darido, Fei Liu, Maciej Maselko, Shoba Ranganathan
Summary: Immune therapies have shown promising results in the treatment of head and neck cancer by boosting the patient's immune system to fight tumor spread. This review highlights recent clinical success in the field of head and neck cancer immunotherapy, including the development of immune checkpoint inhibitors and a human papilloma virus vaccine. The review also emphasizes the importance of understanding basic biology and implementing personalized immunotherapy for better treatment outcomes.
Article
Gastroenterology & Hepatology
Smitha Rose Georgy, Diar Riyanti Rudiatmoko, Alana Auden, Darren Partridge, Tariq Butt, Seema Srivastava, Nick Wong, Dijina Swaroop, Marina Rose Carpinelli, Mirjana Bogeski, Stephen M. Jane
Summary: The transcription factor GRHL3 functions as a tumor suppressor in esophageal squamous cell carcinoma by regulating HOPX expression and Wnt signaling. The study highlights the potential of targeted therapies against the Wnt/beta-catenin pathways in patients with reduced GRHL3 expression.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Charbel Darido, Smitha R. Georgy, Carleen Cullinane, Darren D. Partridge, Rachael Walker, Seema Srivastava, Suraya Roslan, Marina R. Carpinelli, Sebastian Dworkin, Richard B. Pearson, Stephen M. Jane
CELL DEATH AND DIFFERENTIATION
(2018)