Co-targeting of EGF receptor and neuropilin-1 overcomes cetuximab resistance in pancreatic ductal adenocarcinoma with integrin β1-driven Src-Akt bypass signaling

Distinct effects of β1 integrin on cell proliferation and cellular signaling in MDA-MB-231 breast cancer cells

(2016) Sicong Hou et al.   Scientific Reports

Neuropilin Functions as an Essential Cell Surface Receptor

(2015) Hou-Fu Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integrin traffic - the update

(2015) N. De Franceschi et al.   JOURNAL OF CELL SCIENCE

Immunoglobulin Fc-fused, neuropilin-1-specific peptide shows efficient tumor tissue penetration and inhibits tumor growth via anti-angiogenesis

(2015) Ye-Jin Kim et al.   JOURNAL OF CONTROLLED RELEASE

Pancreatic cancer: from state-of-the-art treatments to promising novel therapies

(2015) Ignacio Garrido-Laguna et al.   Nature Reviews Clinical Oncology

Integrins and cancer: regulators of cancer stemness, metastasis, and drug resistance

(2015) Laetitia Seguin et al.   TRENDS IN CELL BIOLOGY

Neuropilins are multifunctional coreceptors involved in tumor initiation, growth, metastasis and immunity

(2015) Gerald J Prud'homme et al.   Oncotarget

In Pancreatic Carcinoma, Dual EGFR/HER2 Targeting with Cetuximab/Trastuzumab Is More Effective than Treatment with Trastuzumab/Erlotinib or Lapatinib Alone: Implication of Receptors' Down-regulation and Dimers' Disruption

(2015) Christel Larbouret et al.   NEOPLASIA

Cotargeting of Epidermal Growth Factor Receptor and PI3K Overcomes PI3K-Akt Oncogenic Dependence in Pancreatic Ductal Adenocarcinoma

(2014) M. H. Wong et al.   CLINICAL CANCER RESEARCH

Protein kinase LKB1 promotes RAB7-mediated neuropilin-1 degradation to inhibit angiogenesis

(2014) Imoh S. Okon et al.   JOURNAL OF CLINICAL INVESTIGATION

A general strategy for generating intact, full-length IgG antibodies that penetrate into the cytosol of living cells

(2014) Dong-Ki Choi et al.   mAbs

Tumor-Penetrating iRGD Peptide Inhibits Metastasis

(2014) K. N. Sugahara et al.   MOLECULAR CANCER THERAPEUTICS

Enhancement of the Tumor Penetration of Monoclonal Antibody by Fusion of a Neuropilin-Targeting Peptide Improves the Antitumor Efficacy

(2014) T.-H. Shin et al.   MOLECULAR CANCER THERAPEUTICS

Drugging the undruggable RAS: Mission Possible?

(2014) Adrienne D. Cox et al.   NATURE REVIEWS DRUG DISCOVERY

Bispecific Antibody to ErbB2 Overcomes Trastuzumab Resistance through Comprehensive Blockade of ErbB2 Heterodimerization

(2013) B. Li et al.   CANCER RESEARCH

Erlotinib Resistance in Lung Cancer Cells Mediated by Integrin  1/Src/Akt-Driven Bypass Signaling

(2013) R. Kanda et al.   CANCER RESEARCH

A Heterodimeric Fc-Based Bispecific Antibody Simultaneously Targeting VEGFR-2 and Met Exhibits Potent Antitumor Activity

(2013) H.-J. Choi et al.   MOLECULAR CANCER THERAPEUTICS

The quest to overcome resistance to EGFR-targeted therapies in cancer

(2013) Curtis R Chong et al.   NATURE MEDICINE

Neuropilin-1Stimulates Tumor Growth by Increasing Fibronectin Fibril Assembly in the Tumor Microenvironment

(2012) Usman Yaqoob et al.   CANCER RESEARCH

Yes and Lyn play a role in nuclear translocation of the epidermal growth factor receptor

(2012) M Iida et al.   ONCOGENE

Distinct Recycling of Active and Inactive β1 Integrins

(2012) Antti Arjonen et al.   TRAFFIC

Reconstruction of integrin activation

(2011) F. Ye et al.   BLOOD

Epidermal Growth Factor Receptor in Pancreatic Cancer

(2011) Melissa Oliveira-Cunha et al.   Cancers

Neuropilin-1 antagonism in human carcinoma cells inhibits migration and enhances chemosensitivity

(2010) H Jia et al.   BRITISH JOURNAL OF CANCER

Phase III Study Comparing Gemcitabine Plus Cetuximab Versus Gemcitabine in Patients With Advanced Pancreatic Adenocarcinoma: Southwest Oncology Group–Directed Intergroup Trial S0205

(2010) Philip A. Philip et al.   JOURNAL OF CLINICAL ONCOLOGY

Understanding resistance to EGFR inhibitors—impact on future treatment strategies

(2010) Deric L. Wheeler et al.   Nature Reviews Clinical Oncology

A novel agonistic antibody to human death receptor 4 induces apoptotic cell death in various tumor cells without cytotoxicity in hepatocytes

(2009) E.-S. Sung et al.   MOLECULAR CANCER THERAPEUTICS

Neuropilin-1/GIPC1 Signaling Regulates α5β1 Integrin Traffic and Function in Endothelial Cells

(2009) Donatella Valdembri et al.   PLOS BIOLOGY