A general strategy for generating intact, full-length IgG antibodies that penetrate into the cytosol of living cells

Construction of a Large Synthetic Human Fab Antibody Library on Yeast Cell Surface by Optimized Yeast Mating

(2014) Du-San Baek et al.   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Delivery of antibodies to the cytosol

(2014) Andrea LJ Marschall et al.   mAbs

Enhancement of the Tumor Penetration of Monoclonal Antibody by Fusion of a Neuropilin-Targeting Peptide Improves the Antitumor Efficacy

(2014) T.-H. Shin et al.   MOLECULAR CANCER THERAPEUTICS

Comparison of the Inhibition Mechanisms of Adalimumab and Infliximab in Treating Tumor Necrosis Factor α-Associated Diseases from a Molecular View

(2013) Shi Hu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Implications of receptor-mediated endocytosis and intracellular trafficking dynamics in the development of antibody drug conjugates

(2013) Michael Ritchie et al.   mAbs

Targeting endogenous nuclear antigens by electrotransfer of monoclonal antibodies in living cells

(2013) Guillaume Freund et al.   mAbs

Heparan sulfate proteoglycan as a cell-surface endocytosis receptor

(2013) Helena C. Christianson et al.   MATRIX BIOLOGY

Chemical inhibition of prometastatic lysyl-tRNA synthetase–laminin receptor interaction

(2013) Dae Gyu Kim et al.   Nature Chemical Biology

Targeting protein–protein interactions as an anticancer strategy

(2013) Andrei A. Ivanov et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Xentry, a new class of cell-penetrating peptide uniquely equipped for delivery of drugs

(2013) Kristopher Montrose et al.   Scientific Reports

Arginine Topology Controls Escape of Minimally Cationic Proteins from Early Endosomes to the Cytoplasm

(2012) Jacob S. Appelbaum et al.   CHEMISTRY & BIOLOGY

A novel chimeric cell-penetrating peptide with membrane-disruptive properties for efficient endosomal escape

(2012) Fabrizio Salomone et al.   JOURNAL OF CONTROLLED RELEASE

A Cell-Penetrating Bispecific Antibody for Therapeutic Regulation of Intracellular Targets

(2012) R. H. Weisbart et al.   MOLECULAR CANCER THERAPEUTICS

Cellular Internalization Mechanism and Intracellular Trafficking of Filamentous M13 Phages Displaying a Cell-Penetrating Transbody and TAT Peptide

(2012) Aeyung Kim et al.   PLoS One

A dual-targeting antibody against EGFR-VEGF for lung and head and neck cancer treatment

(2011) Hongzheng Zhang et al.   INTERNATIONAL JOURNAL OF CANCER

Targeting antibodies to the cytoplasm

(2011) Andrea L.J. Marschall et al.   mAbs

Virus Entry by Endocytosis

(2010) Jason Mercer et al.   Annual Review of Biochemistry

Mechanisms of Endocytosis

(2009) Gary J. Doherty et al.   Annual Review of Biochemistry

A nucleic acid-hydrolyzing antibody penetrates into cells via caveolae-mediated endocytosis, localizes in the cytosol and exhibits cytotoxicity

(2009) J. Y. Jang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Humanization of an agonistic anti-death receptor 4 single chain variable fragment antibody and avidity-mediated enhancement of its cell death-inducing activity

(2009) Seung-Hyun Lee et al.   MOLECULAR IMMUNOLOGY

Construction of a large synthetic human scFv library with six diversified CDRs and high functional diversity

(2009) Hye Young Yang et al.   MOLECULES AND CELLS

Gene silencing by cell-penetrating, sequence-selective and nucleic-acid hydrolyzing antibodies

(2009) Woo-Ram Lee et al.   NUCLEIC ACIDS RESEARCH

Generation of humanized anti-DNA hydrolyzing catalytic antibodies by complementarity determining region grafting

(2008) Dong-Sik Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Heparan Sulfate-Binding Foot-and-Mouth Disease Virus Enters Cells via Caveola-Mediated Endocytosis

(2008) V. O'Donnell et al.   JOURNAL OF VIROLOGY

The E3 Ubiquitin Ligase WWP1 Selectively Targets HER4 and Its Proteolytically Derived Signaling Isoforms for Degradation

(2008) S.-M. Feng et al.   MOLECULAR AND CELLULAR BIOLOGY

Crystal structure of single-domain VL of an anti-DNA binding antibody 3D8 scFv and its active site revealed by complex structures of a small molecule and metals

(2008) Suk-Youl Park et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Role of Cellular Heparan Sulfate Proteoglycans in Infection of Human Adenovirus Serotype 3 and 35

(2008) Sebastian Tuve et al.   PLoS Pathogens

Internalization via Antennapedia protein transduction domain of an scFv antibody toward c-Myc protein

(2007) C. Avignolo et al.   FASEB JOURNAL