Promiscuous DNA-binding of a mutant zinc finger protein corrupts the transcriptome and diminishes cell viability

Survey of variation in human transcription factors reveals prevalent DNA binding changes

(2016) L. A. Barrera et al.   SCIENCE

A systematic survey of the Cys2His2 zinc finger DNA-binding landscape

(2015) Anton V. Persikov et al.   NUCLEIC ACIDS RESEARCH

Mutations in Kruppel-like factor 1 cause transfusion-dependent hemolytic anemia and persistence of embryonic globin gene expression

(2014) V. Viprakasit et al.   BLOOD

KLF1 mutations are relatively more common in a thalassemia endemic region and ameliorate the severity of  -thalassemia

(2014) D. Liu et al.   BLOOD

Reactivation of Developmentally Silenced Globin Genes by Forced Chromatin Looping

(2014) Wulan Deng et al.   CELL

Browning of human adipocytes requires KLF11 and reprogramming of PPARγ superenhancers

(2014) Anne Loft et al.   GENES & DEVELOPMENT

An image-based RNAi screen identifies SH3BP1 as a key effector of Semaphorin 3E–PlexinD1 signaling

(2014) Aleksandra Tata et al.   JOURNAL OF CELL BIOLOGY

Structural basis for Klf4 recognition of methylated DNA

(2014) Y. Liu et al.   NUCLEIC ACIDS RESEARCH

Global analysis of Drosophila Cys2-His2 zinc finger proteins reveals a multitude of novel recognition motifs and binding determinants

(2013) M. S. Enuameh et al.   GENOME RESEARCH

New Insights into DNA Recognition by Zinc Fingers Revealed by Structural Analysis of the Oncoprotein ZNF217

(2013) Marylène Vandevenne et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ZFP36L2 is required for self-renewal of early burst-forming unit erythroid progenitors

(2013) Lingbo Zhang et al.   NATURE

Regions outside the DNA-binding domain are critical for proper in vivo specificity of an archetypal zinc finger transcription factor

(2013) J. Burdach et al.   NUCLEIC ACIDS RESEARCH

Klf4 Is a Transcriptional Regulator of Genes Critical for EMT, Including Jnk1 (Mapk8)

(2013) Neha Tiwari et al.   PLoS One

ENU-induced Mutation in the DNA-binding Domain of KLF3 Reveals Important Roles for KLF3 in Cardiovascular Development and Function in Mice

(2013) Lois Kelsey et al.   PLoS Genetics

Ultrashort and progressive 4sU-tagging reveals key characteristics of RNA processing at nucleotide resolution

(2012) L. Windhager et al.   GENOME RESEARCH

Novel roles for KLF1 in erythropoiesis revealed by mRNA-seq

(2012) M. R. Tallack et al.   GENOME RESEARCH

Intragenic Enhancers Act as Alternative Promoters

(2012) Monika S. Kowalczyk et al.   MOLECULAR CELL

Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks

(2012) Cole Trapnell et al.   Nature Protocols

Regulation of Delta-Aminolevulinic Acid Dehydratase by Krüppel-Like Factor 1

(2012) Aurelie D. Desgardin et al.   PLoS One

An encyclopedia of mouse DNA elements (Mouse ENCODE)

(2012) et al.   GENOME BIOLOGY

The multifunctional role of EKLF/KLF1 during erythropoiesis

(2011) M. Siatecka et al.   BLOOD

Mutations in the second zinc finger of human EKLF reduce promoter affinity but give rise to benign and disease phenotypes

(2011) B. K. Singleton et al.   BLOOD

The structure of the Klf4 DNA-binding domain links to self-renewal and macrophage differentiation

(2011) Anja Schuetz et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The Multi-zinc Finger Protein ZNF217 Contacts DNA through a Two-finger Domain

(2011) Noelia Nunez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic labeling of RNA uncovers principles of RNA production and degradation dynamics in mammalian cells

(2011) Michal Rabani et al.   NATURE BIOTECHNOLOGY

Analysis of protein-ligand interactions by fluorescence polarization

(2011) Ana M Rossi et al.   Nature Protocols

Total RNA sequencing reveals nascent transcription and widespread co-transcriptional splicing in the human brain

(2011) Adam Ameur et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Dominant Mutation in the Gene Encoding the Erythroid Transcription Factor KLF1 Causes a Congenital Dyserythropoietic Anemia

(2010) Lionel Arnaud et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The Discovery of Zinc Fingers and Their Applications in Gene Regulation and Genome Manipulation

(2010) Aaron Klug   Annual Review of Biochemistry

The genome-wide dynamics of the binding of Ldb1 complexes during erythroid differentiation

(2010) E. Soler et al.   GENES & DEVELOPMENT

A global role for KLF1 in erythropoiesis revealed by ChIP-seq in primary erythroid cells

(2010) M. R. Tallack et al.   GENOME RESEARCH

Mutation in erythroid specific transcription factor KLF1 causes Hereditary Spherocytosis in the Nan hemolytic anemia mouse model

(2010) Daniel P. Heruth et al.   GENOMICS

KLF1 directly coordinates almost all aspects of terminal erythroid differentiation

(2010) Michael R. Tallack et al.   IUBMB LIFE

EKLF Directly Activates the p21 WAF1/CIP1 Gene by Proximal Promoter and Novel Intronic Regulatory Regions during Erythroid Differentiation

(2010) Miroslawa Siatecka et al.   MOLECULAR AND CELLULAR BIOLOGY

Severe anemia in the Nan mutant mouse caused by sequence-selective disruption of erythroid Kruppel-like factor

(2010) M. Siatecka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hematologic characterization and chromosomal localization of the novel dominantly inherited mouse hemolytic anemia, neonatal anemia (Nan)

(2009) Robert A. White et al.   BLOOD CELLS MOLECULES AND DISEASES

EKLF/KLF1 Controls Cell Cycle Entry via Direct Regulation of E2f2

(2009) Michael R. Tallack et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MEME SUITE: tools for motif discovery and searching

(2009) T. L. Bailey et al.   NUCLEIC ACIDS RESEARCH

Integration of External Signaling Pathways with the Core Transcriptional Network in Embryonic Stem Cells

(2008) Xi Chen et al.   CELL

Model-based Analysis of ChIP-Seq (MACS)

(2008) Yong Zhang et al.   GENOME BIOLOGY